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Aging of hematopoietic stem cells (HSCs) is characterized by lineage bias, increased clonal expansion, and functional decrease. At the molecular level, aged HSCs typically display metabolic dysregulation, upregulation of inflammatory pathways, and downregulation of DNA repair pathways. Cellular aging of HSCs, driven by cell-intrinsic and cell-extrinsic factors, causes a predisposition to anemia, a
Relative and absolute intensity-based protein quantification across cell lines, tissue atlases and tumour datasets is increasingly available in public datasets. These atlases enable researchers to explore fundamental biological questions, such as protein existence, expression location, quantity and correlation with RNA expression. Most studies provide MS1 feature-based label-free quantitative (LFQ
Airborne SARS-CoV-2 is considered to play a major role in covid-19 transmission, and several studies have reported its presence in hospital environments, including corridors, patient rooms, cohort rooms and ICUs (Dinoi et al., 2022). The risk of airborne virus have been associated with a number of factors, such as low ventilation, high patient viral load and in some cases, certain medical procedur
Airborne SARS CoV 2 is considered to play a major role in covid 19 transmission, and has been found in several hospital environments. There is a need to investigate the presence of airborne SARS CoV 2 in other hospital areas than traditional infectious disease wards. The results from the present study can contribute to a better understanding of the risk of covid 19 transmission by aerosols at deli
Background: Tamoxifen is an established treatment for breast cancer, but its long-term effects on survival and on secondary cancers are not fully evaluated. Material and methods: We studied 30 years outcome of 4124 postmenopausal patients who were randomized to receive (totally) two or five years of adjuvant tamoxifen. Results: After 5 years of follow-up, when tamoxifen treatment was finished in b
Background/Aims Self-rated health before, during and after pregnancy is important for women s quality of life and promotes bonding between mother and child. However, diverse aspects of care models influence women s experiences during pregnancy. This study aimed to investigate low?risk women s self-rated health during the perinatal period in relation to different models of care in Sweden. Methods A
This article discusses the relationship between undocumentedness, informality, and vulnerability to crime among migrants, using the strain theory as a conceptual framework. Research on victimisation and engagement in crime among migrants is limited, and existing studies tend to focus on one aspect rather than the interplay between the two. This study focuses on the experiences of the Uzbek communi
The diagnosis of Parkinsonian disorders is currently based on clinical criteria, which have limited sensitivity until most dopaminergic neurons are lost. Here we show that cerebrospinal fluid levels of DOPA decarboxylase (DDC) (also known as aromatic L-amino acid decarboxylase) can accurately identify patients with Lewy body disease (LBD) (area under the curve (AUC) = 0.89; PFDR = 2.6 × 10-13) and
With the introduction of information theory in the middle of the 20th century, the concept of noise came to be contrasted with signal. The exhibition Noise to Signal mainly consists of two projects that highlight the relative nature of these terms.The three textile works, all with the title Untitled (Noise), appear abstract but also represent a grainy filter that is usually applied to digital imag
This study investigates the relationship between changes in the frequency of dwell time delays and passenger flow characteristics and the frequency of railway service during the COVID-19 pandemic. To do so we make use of automatic passenger count data from commuter trains in Southern Sweden. Our findings show that the frequency of dwell time delays decreased under COVID-19 conditions compared to t
As the effects of climate change, political upheaval and ravaging war are palpable, apocalyptic images as well as the concept ‘apocalyptic’ are today regularly invoked in politics, popular culture and mass media. This essay ponders the potential dangers of the apocalyptic imaginary, especially its tendency to encourage idealization of one’s own community and demonization of the other. As carriers
THE LITTLE STINT Calidris minuta is an Arctic wader species that migrates through the Baltic Sea region towards wintering areas in North and West Africa and the Mediterranean region. We use a 75-year trapping series, comprising 4,791 Little Stints on autumn migration, from Ottenby Bird Observatory in Sweden to illustrate long-term trends in abundance, phenology, and morphometrics. Numbers of trapp
In order to rationally allocate multi-path component (MPC) of wireless channels to different clusters, a multi-path clustering algorithm based on Bisecting K-means clustering was proposed for millimeter-wave channels to solve the problem of partial optimization of traditional K-means clustering methods. The MPC clustering was implemented based on the cluster split and iteration computation strateg
This paper addresses one of the pedagogical challenges that followed the presence of increasingly multinational student groups, particularly the increased diversity of academic backgrounds among students. Theoretically, this challenge can be understood as an encounter between different teaching and learning regimes (TLRs). TLR, coined by Trowler and Cooper (2002), implies a constellation of assump
Context: In the contemporary body of software engineering literature, some recurrent shortcomings characterize how threats to validity (TTV) are considered in studies. Objective: With this position paper, we aim to open a discourse on the current use of TTV sections. The goal of our position is to jointly reflect and systematically improve how we, as a research community, consider TTV in our studi
Objective: Using Swedish nationwide registry data, we investigated the contribution of genetic and environmental risk factors to the etiology of alcohol use disorder (AUD) by extended twin pedigree modeling. Method: AUD was defined using public inpatient, outpatient, prescription, and criminal records. Three-generational pedigrees were selected for index individuals born between 1980 and 1990, obt
Assertions are one of the most useful automated techniques for checking program’s behaviour and hence have been used for different verification and validation tasks. We provide an overview of the last two decades of research involving ‘assertions’ in software testing. Based on a term–based search, we filtered the inclusion of relevant papers and synthesised them w.r.t. the problem addressed, the s
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