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Age is a critical determinant of arterial disease, including aneurysm formation. Here, to understand the impact of aging on the arterial transcriptome, we leveraged RNA-sequencing data to define transcripts that change with advancing age in human arteries. Among the most repressed transcripts in agedindividuals were those that are relevant for actomyosin structure and organization, including both Age is a critical determinant of arterial disease, including aneurysm formation. Here, to understand the impact of aging on the arterial transcriptome, we leveraged RNA-sequencing data to define transcripts that change with advancing age in human arteries. Among the most repressed transcripts in aged individuals were those that are relevant for actomyosin structure and organization, including both

Temperature influences the transmission of mosquito-borne pathogens with significant implications for disease risk under climate change. Mathematical models of mosquito-borne infections rely on functions that capture mosquito-pathogen interactions in response to temperature to accurately estimate transmission dynamics. For deriving these functions, experimental studies provide valuable data on the

The mechanisms that underlie obsessive-compulsive disorder (OCD) are elusive. The habit formation model of OCD postulates that compulsions arise from an imbalance between goal-directed and habit formation systems, stemming from impaired inhibition of stimulus-driven actions. Few studies have examined the core tenets of the habit formation model in pediatric OCD. We administered the object-interfer

The forest floor acts as a source of terpenoid emissions to the atmosphere. These emissions can further impact atmospheric particle formation and impact the atmospheric radiation balance. Climate change escalates wildfire frequency in boreal forests. Wildfires are major disturbances with long-term ecosystem impacts, particularly on the forest floor, significantly influencing terpenoid sources and

Background/Objectives: Fertility-sparing surgery (FSS) is a standard practice for managing early stage cervical cancer, yet significant variation exists in clinical approaches worldwide. Our objective was to ascertain current practices and preferences for cerclage use among expert centers globally regarding FSS in patients with early stage cervical cancer. Methods: We conducted a cross-sectional s

Objective: Several surgical approaches are being used in the reconstruction of long-gap esophageal atresia. We investigated which methods are being used in the Nordic countries and the postoperative complications that occurred in the first year of life. Methods: This study is a retrospective multicenter study, where medical records on children with esophageal atresia Gross type C or D born in the

A quantum description is given of nanoskyrmions in two-dimensional textures with localized spins and itinerant electrons, isolated or coupled to leads, in or out of equilibrium. The spin-electron exchange is treated at the mean-field level, while tensor networks and exact diagonalization or nonequilibrium Green's functions are used for localized spins and itinerant electrons. We motivate our schem

The efficacy of cancer immunotherapy relies on the recruitment and activation of cytotoxic T cell responses against solid tumors by type 1 conventional dendritic cells (cDC1s). However, the generation of cDC1s for cancer immunotherapy faces significant limitations, including poor cell yield, functional heterogeneity, and susceptibility to immunosuppression in the tumor microenvironment (TME). We r

• Purpose: Controversy exists regarding the comparative efficacy of collagenase injection and percutaneous needle fasciotomy in the treatment of Dupuytren contracture. The randomized controlled trials (RCTs) that have compared the two treatment methods have reported results mostly implying similar treatment efficacy, durability, and complications. We aimed to review these RCTs regarding methodical

After World War II, the ethno-demographic structure of many cities in eastern and central Europe was fundamentally changed as a result of genocides, ethnic cleansing, deportations and migrations. The cultural diversity that had been characteristic of many of those cities was radically reduced, as new inhabitants tried to find their place in the cityscapes. In focus of this thesis is thememory work

Flux equations describing brain D-glucose uptake are presented for up to four tissue compartments: blood, endothelial intracellular space in the blood-brain barrier (BBB), extravascular-extracellular space (EES), and intracellular space. Transport rates are described by Michaelis-Menten kinetics, including half-saturation constants ( K T ) and maximum rates for transport ( T max )