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Monoclonal anti-collagen type II antibody CIIC1 is an arthritogenic autoantibody, which induces arthritis in mice. We crystallized and solved the structure of CIIC1 Fab molecule. Analysis of structure revealed an interaction between the CDR regions of one Fab to the CH1 domain of another Fab, which resembles an antibody-antigen interaction. ELISA experiments confirmed the cross-reactivity of both
Object: This study investigates the outcome after traumatic brain injury (TBI) in mice lacking the essential DNA repair gene xeroderma pigmentosum group A (XPA). As damage to DNA has been implicated in neuronal cell death in various models, the authors sought to elucidate whether the absence of an essential DNA repair factor would affect the outcome of TBI in an experimental setting. Methods: Th
Fuel cells are promising for future energy systems, since they are energy efficient and, when hydrogen is used as fuel, there are no emissions of greenhouse gases. Fuel cells have during recent years various improvements, however the technology is still in the early phases of development. This can be noted by the lack of a dominant design both for singe fuel cells, stacks and for entire fuel cell
Many studies have reported higher total plasma homocysteine (tHcy) in elderly patients with mental illness than in control subjects. There are many different determinants of plasma tHcy concentration, including age, cobalamin/folate status, renal function and the presence of vascular disease. The presence of vascular disease may contribute to cognitive impairment. We have investigated elderly pati
OBJECTIVE: Heart rupture is a devastating complication to negative pressure wound therapy in cardiac surgery. Also, reduced cardiac output during negative pressure wound therapy has been reported. The present study aimed to examine the effects of negative pressure wound therapy on the position of the heart in relation to the thoracic wall using magnetic resonance imaging in a porcine sternotomy wo
Remote laser-induced fluorescence monitoring can complement passive reflectance measurements on vegetation. Vegetation classification and status assessment is normally performed by air- or spaceborne multi-spectral scanners. An increased research activity in the field of vegetation monitoring is motivated by the abundant stressed forests of Europe. We have used a mobile lidar system for remote stu
Abstract in Undetermined Archaeological research on pre-Christian religion has increased greatly during the last two decades. Studies of ritual and religion appear frequently in scholarly, popular and antiquarian publications of the 1990s. Selected publications in Scandinaviau archaeology are presented in order to characterise and discuss different approaches. Central theoretical and methodologica
The T-matrix method is applied to the problem of scattering of Rayleigh-Lamb modes from a twodimensional cavity in an elastic plate. A formal solution is obtained which is valid also for non-planar surfaces. Explicit expressions and numerical results are given for a plate with plane surfaces.
