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The entrepreneurial ecosystem (EE) literature has attracted much attention, especially in policy circles. However, the concept suffers from a number of shortcomings: (1) it lacks a clear analytical framework that makes explicit what is cause and what is effect in an EE; (2) while being a systemic concept, the EE has not yet fully exploited insights from network theory, and it is not always clear i
Activation of AMP-activated protein kinase (AMPK) in endothelial cells regulates energy homeostasis, stress protection and angiogenesis, but the underlying mechanisms are incompletely understood. Using a label-free phosphoproteomic analysis, we identified glutamine:fructose-6-phosphate amidotransferase 1 (GFAT1) as an AMPK substrate. GFAT1 is the rate-limiting enzyme in the hexosamine biosynthesis
One of the key elements in a polymer electrolyte fuel cell (PEFC) is the gas diffusion layer (GDL). The GDL offers mechanical support to the cell and provides the medium for diffusing the reactant gases from the flow plates to the electrolyte enabling the electrochemical reactions, and therefore the energy conversion. At the same time, it has the task of transporting the electrons from the active
In a world where technical knowledge gets outdated in an ever increasing speed, it is important that engineering education provides students not only with broad technical competences but also with so-called soft skills such as communications skills, leadership skills and team-working skills. When it comes to team-working skills, group projects have become an inevitable part of most LTH programs. L
AIM: To investigate the antitumour effect of radiation in combination with electropermeabilization on subcutaneous rat glioma tumours.MATERIALS AND METHODS: Sub-optimal radiation treatment was administered separately or in combination with electric pulses of high voltage to subcutaneous rat brain tumours. The treatment was repeated on four consecutive days and evaluated by TGD and microscopical ex
A protocol was developed to study the drug uptake from in vivo electropermeabilization at different settings of parameters influencing the uptake efficiency. Radiolabelled diethylenetriaminepentaacetic acid (DTPA) was used to trace the distribution and internalization of a hydrophilic drug after in vivo electropermeabilization. Skeletal muscle tissue in rat was treated with permeabilizing electric
This article provides an overview of the literature on demonstration projects and trials, and accounts for how insights drawn from this literature can contribute to the development of a sustainable bioeconomy. The article reviews the literature on demonstration projects and trials, covering both more broad-based studies on demonstration projects mainly carried out in the US and more specific studi
High-resolution γ-ray spectroscopy has been established at ISOLDE for nuclear-structure and nuclear-reaction studies with reaccelerated radioactive ion beams provided by the REX-ISOLDE facility. The MINIBALL spectrometer comprises 24 six-fold segmented, encapsulated high-purity germanium crystals. It was specially designed for highest γ-ray detection efficiency which is advantageous for low-intens
This paper presents a study of the physical limitations for radio frequency absorption in gold nanoparticle (GNP) suspensions. A spherical geometry is considered consisting of a spherical suspension of colloidal GNPs characterized as an arbitrary passive dielectric material which is immersed in an arbitrary lossy medium. A relative heating coefficient and a corresponding optimal near field excitat
Ions differ in their ability to salt out proteins from solution as expressed in the lyotropic or Hofmeister series of cations and anions. Since its first formulation in 1888, this series has been invoked in a plethora of effects, going beyond the original salting out/salting in idea to include enzyme activities and the crystallization of proteins, as well as to processes not involving proteins lik
Lifetimes of excited states in Y99,Y101,Nb101,Nb103, and Nb105 were measured in an experiment using the recoil distance Doppler shift method at GANIL (Grand Accélérateur National d'Ions Lourds). The neutron-rich nuclei were produced in fission reactions between a U238 beam and a Be9 target. Prompt γ rays were measured with the EXOGAM array and correlated with fission fragments that were identified
The determination of |Vus| from kaon semileptonic decays requires the value of the form factor f+(q2 = 0) which can be calculated precisely on the lattice. We provide the one-loop partially quenched chiral perturbation theory expressions both with and without including the effects of staggered quarks for all form factors at finite volume and with partially twisted boundary conditions for both the
This paper presents a dynamical model of high speed motorized spindles in free state and work state. In the free state, the housing is modeled as a rotor with equivalent masses including bearing pedestals, motor stator and rear end cover. As a consequence, a double rotor dynamics can be modeled for high speed motorized spindles by a bearing element which connects the housing and bearing pedestals.
Ovarian cancer patients are typically treated with carboplatin and paclitaxel, but suffer a high rate of relapse with recalcitrant disease. This challenge has fostered the development of novel approaches to treatment, including antagonists of the 'inhibitor of apoptosis proteins' (IAPs), also called SMAC mimetics, as apoptosis-inducing agents whose action is opposed by caspase inhibitors. Surprisi
This paper presents the features of a survey on Swedish firms’ export decisions conducted in February 2015 focusing on a sample of 10,000 small and medium-sized enterprises. The survey was divided into two major sections. The first section targeted all firms and focused on firms’ general situation (e.g. competition, type of co-operations, etc.). The second section focused on firms’ export decision
This thesis concerns the law/fact distinction in law. The interest it takes in the distinction is not practical, but conceptual. It more specifically concerns the questions: “What is it that is conceptually assumed about something when it is categorized as ‘of law’ or ‘of fact’?” and “What is conceptually assumed about the law when law is distinguished from fact by the use of the law/fact distinctThis thesis concerns the law/fact distinction in law. The interest it takes in the distinction is not practical, but conceptual. It more specifically concerns the questions: “What is it that is conceptually assumed about something when it is categorized as ‘of law’ or ‘of fact’?” and “What is conceptually assumed about the law when law is distinguished from fact by the use of the law/fact distinct
This paper presents an advanced signal processing schemefor time-domain induced polarization full waveform data.The scheme includes several steps with an improvedinduced polarization (IP) response gating design usingconvolution with tapered windows to suppress highfrequency noise, a logarithmic gate width distribution foroptimizing IP data quality and an estimate of gatinguncertainty. Additional s
Bleomycin has, in the years of developing electrochemotherapy (ECT), proven to be an extremely potent drug for this cancer treatment modality and is also the most frequently applied chemical agent. It is of importance to investigate the pharmacokinetics of bleomycin under normal conditions and particularly in combination with ECT.
