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High breastfeeding continuation at two months after birth in women receiving home-based postnatal midwifery care and factors associated with breastfeeding cessation – a prospective cohort study

Introduction:Exclusive breastfeeding (EB) is globally recommended due to health benefits for women and their infants. Home-based postnatal midwifery care (HBPMC) is a model of care where midwives give in-home care during the first postnatal week. The study objectives were to investigate breastfeeding outcomes at two months after birth, in women and newborns receiving HBPMC, and to identify risk fa

Random walks in random labyrinths

A random labyrinth is a disordered environment of scatterers on a lattice. A beam of light travels through the medium, and is reflected off the scatterers. The set of illuminated vertices is studied, under the assumption that there is a positive density of points, called `normal points', at which the light behaves in the manner of a simple symmetric random walk. The ensuing `random walk in a labyr

Two Problems about Random Walks in a Random Field of Traps

This paper is about simple random walks on $Z^d$, $d \ge 3$, in a random field of traps, the density of which tends to zero at infinity. We distinguish between the quenched problem (when the traps are fixed) and the annealed problem (when the traps are updated each unit of time). Our goal is not only to find a criterion for zero vs. positive probability of survival, but also to show three differen

Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Germline mutations in BRCA1 and BRCA2 confer high risks of breast cancer. However, evidence suggests that these risks are modified by other genetic or environmental factors that cluster in families. A recent genome-wide association study has shown that common alleles at single nucleotide polymorphisms (SNPs) in FGFR2 (rs2981582), TNRC9 (rs3803662), and MAP3K1 (rs889312) are associated with increas

Outcomes after a first acute myocardial infarction in patients with or without congenital heart disease

Background and AimsThe life expectancy of adult patients with congenital heart disease (ACHD) has improved, thus shifting the research focus towards age-related comorbidities to continue to improve patient outcomes. This study aimed to investigate all-cause mortality and recurrent acute myocardial infarction (AMI) in adults with and without congenital heart disease.MethodsA nationwide case control

An optimized protocol for efficient derivation of pancreatic islets from multiple human pluripotent stem cell lines

The success of cell therapy for type 1 diabetes (T1D) depends on reliable differentiation of stem cells into functional pancreatic islets. Current protocols produce stem cell-derived islets (SC-islets) that contain non-endocrine cells and show limited maturity. We developed a robust protocol that generates functional SC-islets from all eight tested human pluripotent stem cell (hPSC) lines. Differe

Ongoing and completed clinical trials on prostate cancer screening using MRI

Abstract: Before the introduction of prostate MRI, prostate cancer screening relied on prostate-specific antigen (PSA) testing followed by a systematic biopsy. Although this approach reduced prostate cancer mortality in large, randomized screening trials, its net benefit was questionable because of substantial overdiagnosis. In response, more precise screening tools have been developed. Diagnostic

Strategic ambivalence and ontological (in)security : a Lacanian reading of Iran’s involvement in the Russia-Ukraine war

Ambivalence is widely regarded as a source of ontological insecurity and anxiety due to its close association with uncertainty, undecidability, and indeterminacy. While ontological security studies (OSS) has usefully engaged with the concept of ambivalence as an epistemic phenomenon and its manifestations in international politics such as ‘strangers’, almost no attention has been paid to ambivalen

Uncovering the origin of impurities in supercritical fluid chromatography coupled to high-resolution mass spectrometry

Maintaining low background levels is essential for analytical instruments, such as in supercritical fluid chromatography (SFC) coupled to high-resolution mass spectrometry (HRMS). An approximate tenfold increase of the background was observed in our laboratory when a new CO2 cylinder with a dip tube was installed on a SFCHRMS system. Most analyte peaks were obscured. This study aimed to find the c

Genetic predisposition to coffee consumption and the association with the early risk of atherosclerosis

The cardiovascular effects of coffee consumption remain debated, particularly regarding early-stage subclinical atherosclerosis. This study investigated the association between coffee intake, genetic predisposition, and the risk of subclinical coronary and carotid atherosclerosis in 24,835 participants from the Swedish CArdioPulmonary bioImage Study (SCAPIS). Coffee intake was assessed via self-re

Influence of the ion charge state on emission energies of Auger electrons exemplified in Ar and Xe clusters

We report on the shift of energies released during Auger cascades in rare-gas ions, when the ions are not isolated but embedded in a homogeneous cluster. By combining high-resolution electron spectroscopy with multielectron coincidence spectroscopy of small Ar and Xe clusters, we investigate the dependence of Auger electron emission energies on the charge state of the emitting ion in the polarizab

Transfers, Segregation, and Local Labour Markets: Evidence from Three Decades of Declining Transfers

Using Swedish register data for 1993–2022, this paper documents robust spatial heterogeneityin the relationship between transfer generosity and local employment. Transfer reductions areassociated with lower employment among individuals far from the labour market in immigrant-dense neighbourhoods, but with higher employment among individuals with stronger labour-market attachment. This pattern is d

Trigeminal neuralgia is associated with increased risk of cerebrovascular disease, myocardial infarction and suicide – a nationwide Swedish study

Background: Trigeminal neuralgia is sometimes referred to as the suicide disease, but long-term occurrence of comorbidities and mortality are not well known. The aim of the present study was to investigate whether patients diagnosed with trigeminal neuralgia have an increased risk of morbidity and mortality compared to the general population. Methods: A nationwide, retrospective cohort study was c

MAVISp : A modular structure-based framework for protein variant effects

The role of genomic variants in disease has expanded significantly with the advent of advanced sequencing techniques. The rapid increase in identified genomic variants has led to many variants being classified as Variants of Uncertain Significance or as having conflicting evidence, posing challenges for their interpretation and characterization. Additionally, current methods for predicting pathoge

When the proteome meets the metabolome observational and Mendelian randomization analyses

Objective The basis for protein synthesis is the genetic code. Many of these proteins will affect intermediary metabolites by acting as enzymes, hormones, or by other actions. The aim of the present study was to assess the relationships of a large number of proteins with endogenous metabolites. Methods Plasma protein levels were measured by the proximity extension assay (PEA) and metabolites by ma

Data-driven sampled-data LQR : Certainty-equivalence control via lifted cost and Riccati analysis

This letter analyzes certainty-equivalence adaptive controllers for sampled-data systems through a data-driven Riccati equation. Extending a recent framework for data-driven adaptive control, the proposed formulation provides the sampled-data counterpart that explicitly accounts for intersample behavior via lifted cost representations. Sufficient conditions are derived to guarantee stability and r

Enrichment by the first stars in a relic dwarf galaxy

Stars that contain trace amounts of elements heavier than helium (that is, ‘metallicity’) preserve the chemical fingerprints of the first stars. In the Milky Way, nearly all of the lowest-metallicity stars show an extreme over-abundance of carbon. The origin of this signature has remained a mystery owing to the lack of observational constraints on the environments in which it originates. Here we p

High alcohol consumption and early hip fracture risk in men and women

Our aim was to study whether hospitalizations due to high alcohol consumption, as an objective indicator of high alcohol consumption, is associated with hip fractures in non-elderly adults. The participants in this study consist of 10,043 men and women in a survey study in Stockholm 1969-70, when they were 18–25 years old. We used data on hospitalization events due to a hip fracture or a diagnosis

Defect mediated pulse terahertz emission from thiocyanate-treated hybrid perovskite nanoparticles : role of the orientation of built-in surface electric field

Hybrid perovskites have demonstrated exceptional versatility as optoelectronic materials since their introduction as light absorbers and charge transport media in photovoltaic devices. These materials are now utilized in photodetectors, photocatalysis, and light-emitting devices, offering emission capabilities spanning from the ultraviolet to the mid-infrared spectrum. Recent studies in the far-in