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About 40 years ago, a subpopulation of small neurons in the cerebellar nuclei was shown to project to the inferior olive, the source of the climbing fiber input to the cerebellum. This nucleo-olivary projection follows the zonal and probably also microzonal arrangement of the cerebellum so that closed loops are formed between the neurons in the olive, the cerebellar cortex, and the nuclei. Althoug
Permafrost-affected ecosystems are subject to warming and thawing, which can increase the availability of subsurface nitrogen (N) with consequences in otherwise N-limited tundra and alpine vegetation. Here, we quantify the extent of warming and permafrost thawing and the corresponding effects on nitrogen availability and plant growth based on a 20-year survey across 14 sites on the Tibetan Plateau
The emergence of a monkeypox (MPOX) outbreak in 2022 represented the most recent recognizable public health emergency at a global level. Improving knowledge and attitude towards MPOX, particularly among healthcare workers (HCWs), can be a valuable approach in public health preventive efforts aiming to halt MPOX virus spread. The aim of the current study was to evaluate the knowledge and attitude o
Assessing the status of water resources is essential for long-term planning related to water and many other needs of a country. According to climate reports, climate change is on the rise in all parts of the world; however, this phenomenon will have more consequences in arid and semi-arid regions. The aim of this study is to evaluate the effects of climate change on groundwater, surface water, and
Sustainable practices are increasingly promoted in the restaurant industry. One significant aspect of sustainability in restaurants is the use of local supply chains, especially for food, which also serve as a means for restaurants to promote freshness of produce, sourcing, and quality. Considering the prevalence of locality in menu marketing, this study aims to explore the relationships between s
Flimmer kan være irriterende, men frem for alt kan det have en negativ effekt på menneskers sundhed, og forårsage irritation, hovedpine, overanstrengelse af øjne og migræne. Med introduktionen af LED baserede lyskilder og lamper er flimmer igen blevet et problem. Udover denne unødvendige lidelse, som flimmer kan bevirke hos enkeltpersoner, skaber de negative konsekvenser en hindring for bred og hu
Flimmer, eller nærmere bestemt tidslig lys modulation (TLM), er igen blevet et problem i forbindelse med indførelse af LED-basret belysningsteknologi. TLM, dvs. variationer i lysintensiteten over tid, kan have negativ effekt på menneskers sundhed, og forårsage irritation, hovedpine, overanstrengelse af øjne og migræne. Udover denne unødvendige lidelse, som flimmer kan bevirke hos enkeltpersoner, s
Bizarre parosteal osteochondromatous proliferation (BPOP) (Nora lesion) is a benign bone surface lesion, which most commonly occurs in the digits of young patients and has a high rate of recurrence. Histologically, it is composed of a mixture of disorganized bone, cartilage, and spindle cells in variable proportions and characterized by amorphous "blue bone" mineralization. Recurrent chromosomal a
Pancreas-derived islet amyloid polypeptide (IAPP) crosses the blood–brain barrier and co-deposits with amyloid beta (Aβ) in brains of type 2 diabetes (T2D) and Alzheimer’s disease (AD) patients. Depositions might be related to the circulating IAPP levels, but it warrants further investigation. Autoantibodies recognizing toxic IAPP oligomers (IAPPO) but not monomers (IAPPM) or fibrils have been fou
Multidrug-resistant tuberculosis (MDR) continues to pose a threat to public health. Previously, we identified a cationic host defense peptide with activity against Mycobacterium tuberculosis in vivo and with a bactericidal effect against MDR M. tuberculosis at therapeutic concentrations. To understand the mechanisms of this peptide, we investigated its interactions with live M. tuberculosis and li
Introduction: The current study aimed to investigate the rates of anxiety, clinical depression, and suicidality and their changes in health professionals during the COVID-19 outbreak. Materials and methods: The data came from the larger COMET-G study. The study sample includes 12,792 health professionals from 40 countries (62.40% women aged 39.76 ± 11.70; 36.81% men aged 35.91 ± 11.00 and 0.78% no
The presence of CD169+ macrophages in the draining lymph nodes of cancer patients is, for unknown reasons, associated with a beneficial prognosis. We here investigated the prognostic impact of tumor-infiltrating CD169+ macrophages in primary tumors (PTs) and their spatial relation to tumor-infiltrating B and T cells. Using two breast cancer patient cohorts, we show that CD169+ macrophages were spa
Healthcare workers (HCWs) were the first population group offered coronavirus disease 2019 (COVID-19) vaccines in South Africa because they were considered to be at higher risk of infection and required protecting as they were a critical resource to the health system. In some contexts, vaccine uptake among HCWs has been slow, with several studies citing persistent concerns about vaccine safety and
When individuals self-select (or are selected) into a study based on factors that influence the outcome, conclusions may not generalize to the full population. To compensate for this, results may be adjusted, for example, by standardization on the set of common causes of participation and outcome. Although such standardization is useful in some contexts, the common causes of participation and outc
UppdragArbetet med kunskapssammanställningen definierades av Myndigheten förarbetsmiljökunskap till att omfatta den psykosociala arbetsmiljöns inverkanpå den seniora arbetskraften1 i en svensk kontext, det vill säga effekten påindividen utifrån den mentala arbetsmiljö och den arbetssociala miljö somhen befinner sig i. Dock samvarierar olika faktorer i individers arbetssitua-tion. För att fånga in This report from the Swedish Agency for Work Environment Knowledge isconcerned with the impact of the psychosocial work environment — that is,the mental work environment and social work environment — on the seniorworkforce (≥55 years of age) in a Swedish context. However, many differentfactors can affect an individual’s work situation. Therefore, the studies inclu-ded in this literature review hav
Si1−xGex nanowires (NWs) were prepared by gold-supported chemical vapor deposition (CVD) using a single-source precursor with preformed Si–Ge bonds. Besides the tamed reactivity of the precursor, the approach reduces the process parameters associated with the control of decomposition characteristics and the dosing of individual precursors. The group IV alloy NWs are single crystalline with a const
The radial transport, or drift, of dust has taken a critical role in giant planet formation theory. However, it has been challenging to identify dust drift pileups in the hard-to-observe inner disk. We find that the IM Lup disk shows evidence that it has been shaped by an episode of dust drift. Using radiative transfer and dust dynamical modeling we study the radial and vertical dust distribution.
A reflection on the understanding of East Asian philosophy by Martin Buber as it mirrors in this work.
Climate adaptation is not a neutral or apolitical process, but one that ignites social resistance. Government responses to risks of floods, droughts, or hurricanes – even those using a language of participation – might follow historical development pathways, strive to maintain the status quo, and directly or indirectly serve elite interests. Little attention has been paid to how people defy or res
