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Primary HIV-1 R5 isolates from end-stage disease display enhanced viral fitness in parallel with increased gp120 net charge.

To better understand the evolution of the viral envelope glycoproteins (Env) in HIV-1 infected individuals who progress to AIDS maintaining an exclusive CCR5-using (R5) virus population, we cloned and sequenced the env gene of longitudinally obtained primary isolates. A shift in the electrostatic potential towards an increased net positive charge was revealed in gp120 of end-stage viruses. Residue

Regional Innovation System Policy: a Knowledge-based Approach

A focus on constructing regional advantage requires an unpacking of what makes territorial agglomerations important for innovation and growth by disclosing and revealing the contingencies, particularities and specificities of the various contexts and environments where knowledge creation, innovation and entrepreneurship take place. In order to achieve more effective regional innovation policy, the

Vad är rätt? Juridiska och etiska frågor i Certecs vardag

Vardagsarbetet på Certec tangerar ofta etiska och juridiska spörsmål. Detta är mer av godo än av ondo. Det är viktigt för en verksamhet, som bedrivs nära människor, att det etiska samtalet hålls levande, och att frågor ständigt väcks kring vad som kanske rent av är reglerat i lag. Funderingarna och samtalen handlar inte bara om vad som kan vara olagligt eller oetiskt att göra – minst lika ofta gäl

Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer.

Many studies have shown that primary prostate cancers are multifocal and are composed of multiple genetically distinct cancer cell clones. Whether or not multiclonal primary prostate cancers typically give rise to multiclonal or monoclonal prostate cancer metastases is largely unknown, although studies at single chromosomal loci are consistent with the latter case. Here we show through a high-reso

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To dig and to write: Author questions the concept of basic archive reports and argues that the pyramidal working structure of archaeology must be demolished. Drawings by Inger Karlberg.