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Objective To train and validate a deep learning-based diagnostic tool capable of accurately segmenting the alveolar cleft region and automatically estimating the required bone graft volume using cone-beam computed tomography (CBCT) imaging. Study Design Eighty-eight CBCT scans from patients with nonsyndromic unilateral clefts were divided into training (n = 45), validation (n = 10), and test (n =

Engraved ochres and ostrich eggshells from the South African Blombos Cave and Diepkloof Rock Shelter are among the earliest expressions of human symbolic behavior. They appear to document a continuous practice of mark-making across ∼40,000 years. During this time, the engraved markings change from simpler, unstructured patterns to more complex markings such as cross-hatchings. Previous work examin

Aims/hypothesis: The aetiology of type 1 diabetes remains elusive. Family history of type 1 diabetes increases the disease risk but the role of other autoimmune diseases or type 2 diabetes in the family are unclear. Here, we aimed to analyse the effect of family history of diabetes and autoimmune diseases on development of islet autoimmunity and progression to type 1 diabetes. Methods: The Environ

Background: Standardized care pathway (SCP) for macrohematuria (patients aged ≥50 years) in Sweden includes four-phase computed tomography urography (CTU) before cystoscopy, but targeted SCP lead time for CTU (6 days)/treatment is fulfilled in <25% of patients. Purpose: To retrospectively analyze the incidence of CTU-diagnosed upper urinary tract (UUT), kidney and bladder tumors, calculi, radiatio

Acute postoperative pain remains common despite advances in surgical techniques and enhanced recovery protocols, suggesting that patient-specific factors and individualised approaches may be key to improving outcomes. Real-time intraoperative nociceptive monitoring has emerged as a potential tool to guide analgesia and predict postoperative pain bur their role in an individualised anaesthesia fram

Randomised controlled trial (RCT) protocols contain essential details needed to understand and evaluate the trial's planned aims, design, data collection methods, monitoring, data analysis, and participants' safety. However, key information is often omitted from paediatric RCT protocols, including details on dose adjustments of interventions based on age, body surface area, or weight; developmenta

This study analyzes the temporal evolution of the short-term P-wave morphological variability (PWMV) within the one-hour interval immediately preceding the onset of atrial fibrillation (AF) episodes. This PWMV is hypothesized to be an index of vulnerable atrial substrate, allowing to identify instability increases preceding the AF episode onset. We analyzed 32 ambulatory ECG recordings from subjec

För att åstadkomma ett cirkulärt materialhanteringssystem och minska växthusgasutsläppen är materialåtervinning en avgörande faktor. Bygg- och anläggningsbranschen står för runt 20 % av Europas plastanvändning och plast är det vanligaste materialet för tillverkning av rör för vatten och avlopp (VA). Det här examensarbetet syftar till att analysera förutsättningarna för ökad användning av VA-rör avTo achieve a circular material management system and reduce greenhouse gas emissions, material recycling is a crucial factor. The construction and civil engineering sectors together account for 20 % of Europe’s plastic consumption, and plastic is the most common material used in the manufacturing of water and wastewater pipes. This master’s thesis aims to analyse the possibilities for increased us

Decarbonising the built environment is essential to mitigating the climate crisis, as buildings significantly contribute to greenhouse gas emissions. Adaptive reuse presents a sustainable alternative to demolition and new construction. This study evaluated the Global Warming Potential (GWP) of an adapted building through renovation and operation across three scenarios, compared to a reference scen

Adeno-associated viral vectors have become a leading choice for gene therapy in the central nervous system due to their safety profile, efficient neuronal transduction, and capacity for sustained transgene expression. We previously reported that AAV2-derived capsids developed using the BRAVE (Barcoded Rational AAV Vector Evolution) approach have enhanced retrograde transport properties in the rode

Purpose of review – Small cell lung cancer (SCLC), particularly its transdifferentiated form, is highly aggressive and has a poor prognosis. The diagnosis of SCLC transdifferentiation is challenging, as repeat biopsies are often not clinically feasible and few noninvasive predictors of this neuroendocrine transformation have been identified to date. Recent findings – Some retrospective studies and

Background: Normal hand function relies on a finely tuned interaction between the sensory and motor systems within the central and peripheral nervous systems. The central nervous system continuously adapts to changed activity, environmental changes, learning, and injury — a phenomenon known as neuroplasticity. The neuroplasticity is a life-long ability and presents opportunities for therapeutic in

The impact of the COVID-19 pandemic on building energy use has been studied across various countries. However, with the growing trend toward flexible working and the rising frequency of climate-induced extreme weather events, the combined effects of these factors on future energy use remain largely unexplored. This study develops a methodology to investigate the resilience of the UK's low-income h

Crustaceans inhabit a wide variety of habitats, from the open ocean to ephemeral pools. Within these habitats, crustaceans play key roles as herbivores, detritivores, and predators, and interact with competitors ranging from conspecifics to other crustaceans to diverse assemblages of invertebrates. As with most communities and ecosystems, efforts to understand the impacts of crustacean community d

We present a genome assembly from a female specimen of Podarcis vaucheri (Andalusian wall lizard; Chordata; Lepidosauria; Squamata; Lacertidae). The assembly contains two haplotypes with total lengths of 1,614.91 megabases and 1,510.74 megabases. Most of haplotype 1 (98.26%) is scaffolded into 20 chromosomal pseudomolecules, including the W and Z sex chromosomes. Most of haplotype 2 (98.63%) is sc

The 39.4% decline in numbers in the Northeast/Northwest European population of Bewick’s Swan Cygnus columbianus bewickii between 1995 (29,780 birds) and 2010 (18,057 birds) was of major conservation concern, alleviated by a partial recovery to 20,149 recorded in the January 2015 census. The most recent census, in January 2020, however found that the recovery was not sustained. The results describe

Viral hepatitis remains a global health concern, with growing recognition of the impact of hepatitis A virus (HAV), hepatitis E virus (HEV), and herpesvirus-associated hepatitis, particularly in vulnerable groups. This narrative review from the ESCMID Study Group for Viral Hepatitis (ESGVH) summarizes recent advances and expert perspectives. For HAV, insights into viral evolution, epidemiology, an

The increasing datafication of the workplace is often cast as a means of imposing organisational and managerial control on workers. This reflection note moves beyond this view and coins the term data-driven labour organising to discuss the potential of workplace datafication as a way to inform workers about their working conditions and how to use data to advocate for their collective goals. Forgin