Randomized controlled trials (RCT) are often underpowered for validating gene-treatment interactions. Using published data from the Diabetes Prevention Program (DPP), we examined power in conventional and genotype-based recall (GBR) trials. We calculated sample size and statistical power for gene-metformin interactions (vs. placebo) using incidence rates, gene-drug interaction effect estimates and

Given a sequence of numbers (Formula presented.) in [0, 1], consider the following experiment. First, we flip a fair coin and then, at step n, we turn the coin over to the other side with probability (Formula presented.), (Formula presented.), independently of the sequence of the previous terms. What can we say about the distribution of the empirical frequency of heads as (Formula presented.)? We

Glycero-3-phosphocholine (GPC), the product of the complete deacylation of phosphatidylcholine (PC), was long thought to not be a substrate for reacylation. However, it was recently shown that cell-free extracts from yeast and plants could acylate GPC with acyl groups from acyl-CoA. By screening enzyme activities of extracts derived from a yeast knock-out collection, we were able to identify and c

Nonverbal behaviour has an important function in team sports, but research is limited. Adopting a psychological momentum (PM) framework, this study explores the relationship between a team’s history of events, nonverbal post-shot celebrations in the form of gestures and touch shown by the shooter after scoring, and subsequent team performance during handball matches. A naturalistic design with sys

Liaison is a phenomenon of external sandhi that involves the production of a latent coda consonant (liaisonconsonant, LC) in prevocalic contexts (e.g. [z] in des [de] + ânes [an] → des ânes [dezan], (some) donkeys,but not in des [de] + poules [pul] → des poules [depul], (some) hens. The segmental content of the LC isthus dependent on the first word but produced as the onset of the second word: [de

Electron emission caused by extreme ultraviolet (XUV) radiation in the presence of a strong near infrared (NIR) field leads to multiphoton interactions that depend on several parameters. Here, a comprehensive study of the influence of the angle between the polarization directions of the NIR and XUV fields on the two-color angle-resolved photoelectron spectra of He and Ne is presented. The resultin

Background: We aimed to explore the effects of polypharmacy and specific drug classes on readmissions and mortality after hip surgery. Methods: We analyzed data on 272 consecutive hip fracture patients (72.1% females; age 82±9 years) who underwent acute hip replacement. We collected detailed data on the pharmacological treatment upon admission and discharge. Patients were followed up over a period

Background: Most women who have their breast reconstructed are offered NAC reconstruction. Nonetheless, it is unclear what scientific evidence there is for the procedure. The aims of the present systematic review were to evaluate the quality of evidence for benefits and risks with NAC reconstruction, and to examine the evidence for different techniques. Methods: Relevant databases were searched. I

The future electron-ion (eA) collider is expected to probe the high energy regime of the quantum chromodynamics (QCD), with the exclusive vector meson production cross section being one of the most promising observables. In this paper we complement previous studies of exclusive processes presenting a comprehensive analysis of diffractive ρ production at small x. We compute the coherent and incoher

What explains the gender gap in ideology, i.e. the observation that women tend to be more leftist than men? We provide new evidence showing that personality traits play a key role. Using a novel high-quality data set, we show that the mediating (i.e. indirect) effects of gender operating through personality traits by far dominate the direct effects of gender. They also dominate other potential dif

Offentlig upphandling spelar en central roll i samhällsplanering och stadsomvandlingsprojekt, där möjligheten att integrera hållbarhetshänsyn har kommit att uppmärksammas alltmer under de senaste decennierna. Bakgrunden till denna rapport härstammar ur projektet ”Samverkan och hållbarhetshänsyn i bygginköpsprocessen”, finansierat av Formas (Forskningsrådet för miljö, areella näringar

OBJECTIVE: The aim of this study was to evaluate the extent of Activities of Daily Living (ADL) ability impairment in newly arrived Danish asylum seekers. It was hypothesized that exposure to trauma and torture would negatively influence ADL performance and that measures of ADL ability would be lower in individuals exposed to torture as compared to the non-tortured.SUBJECTS: Forty-three newly arri

Environmental loads from the building and its services must be minimised. The study aims to determine material quantities, manufacturing energy and how material choice affect manufacturing energy. An inventory of materials in domestic water, waste water, space heating and ventilation services are made and manufacturing energy are calculated based on LCA’s. Finally energy need for alternative mater

Municipal wastewater treatment involves mechanical, biological and chemical treatment steps for protecting the environment from adverse effects. The biological treatment step consumes the most energy and can create greenhouse gases. This study investigates municipal wastewater treatment without the biological treatment step, including the effects of different pretreatment configurations, for examp

Min avhandling handlar om hur barns medfödda temperamentsegenskaper påverkar deras risktagande. Temperamentsegenskaper antas avspegla aktiviteten i biologiskt nedärvda motivationssystem. Aktiviteten i dessa avgör hur snabbt, hur starkt och hur länge vi kommer att reagera i olika situationer. I vår första studie ville vi studera psykometriska egenskaper hos det frågeformulär vi avsåg att använda i This thesis concerns temperamental qualities and their influence on risk-taking behavior during middle childhood (7–11 years of age). Contemporary research generally agrees upon the notion that temperament constitutes two motivational systems, sensitive to punishment and reward respectively, together with a third system that is responsible for regulating the motivational systems. Risk-taking is ge

Chemical potentials of quaternary liquid alloys are required for theoretical description of the composition and crystal structure of Au-catalyzed ternary III-V nanowires. However, such data are solely missing in the literature. Herein, we use a thermodynamic database for the quaternary Au-In-Ga-As system that has been developed using the CALPHAD (CALculation of PHAse Diagram) method. We present th

Patients pretreated with ticagrelor with less than 1 hour from percutaneous coronary intervention (PCI) or receiving ticagrelor in cath lab were prospectively included and received cangrelor. Cangrelor was infused for 2 hours and platelet function was assessed as P2Y12 reactivity units (PRU) with the VerifyNow P2Y12 function assay before start of infusion, 15 min after the start of infusion, and 3

Amyloid-β (Aβ) is a 39-42 residue protein produced by the cleavage of the amyloid precursor protein (APP), which subsequently aggregates to form cross-β amyloid fibrils that are a hallmark of Alzheimer's disease (AD). The most prominent forms of Aβ are Aβ1-40 and Aβ1-42, which differ by two amino acids (I and A) at the C-terminus. However, Aβ42 is more neurotoxic and essential to the etiology of A