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Background: We previously showed that a VLDL-and LDL-rich mix of human native lipoproteins induces a set of repressive epigenetic marks, i. e. de novo DNA methylation, histone 4 hypoacetylation and histone 4 lysine 20 (H4K20) hypermethylation in THP-1 macrophages. Here, we: 1) ask what gene expression changes accompany these epigenetic responses; 2) test the involvement of candidate factors mediat

Abstract in Undetermined As a generalization of the commonly assumed Poisson distribution (PD) used to estimate the annual number of peaks over threshold in partial duration series (PDS) model, the negative binomial (NB) distribution is proposed in this study. Instead of generalized pareto distribution (GPD) and exponential distribution (ED) models popularly applied to predict the probability of t

Purpose. Male breast cancer (MBC) is an uncommon disease. In the absence of randomized studies, current guidelines are mainly based on data on the management of female breast cancer (FBC). In light of concerns regarding the quality and extent of management in men, the aim of the present study was to investigate whether there are differences in tumor characteristics, treatment and outcome in male c

Background: Epidemiologic data and animal models suggest that, despite the predominant role of human papillomavirus infection, sex steroid hormones are also involved in the etiology of invasive cervical carcinoma (ICC). Methods: Ninety-nine ICC cases, 121 cervical intraepithelial neoplasia grade 3 (CIN3) cases and 2 control women matched with each case for center, age, menopausal status and blood

The voluntary nature of programs that pay landowners for conservation measures raises the question of what factors favor participation in such programs. This article focuses on the controversial issue of the impact of information on the participation decision. We develop a straightforward model to analyze how information affects this decision, and empirically estimate the impact of information, as

Hemming Ivar Virgin (1918-2005) was a pioneer in plant photobiology.The main topics of his research covered areas such as light effects on viscosity of protoplasm, determination of turgor and elasticity of plant organs, chlorophyll formation and accumulation, plastid development during greening, and phytochrome regulation of physiological processes.

Moodysson J. and Zukauskaite E. Institutional conditions and innovation systems: on the impact of regional policy on firms in different sectors, Regional Studies. This paper deals with institutional conditions in regional innovation systems: how institutions affect the organization of innovation activities among firms; and in what ways regional policy initiatives can be supportive. The analysis dr

Background: Low blood levels of vitamin D (25-hydroxy D3, 25OHD3) in women have been associated with an increased risk of several diseases. A large part of the population may have suboptimal 25OHD3 levels but high-risk groups are not well known. The aim of the present study was to identify determinants for serum levels of 25OHD3 in women, i.e. factors such as lifestyle, menopausal status, diet and

Evidence on the association between dietary flavonoids and lignans and breast cancer (BC) risk is inconclusive, with the possible exception of isoflavones in Asian countries. Therefore, we investigated prospectively dietary total and subclasses of flavonoid and lignan intake and BC risk according to menopause and hormonal receptor status in the European Prospective Investigation into Cancer and Nu

Recension av Herman Lindqvist, Våra kolonier – de vi hade och de som aldrig blev av.

In this paper we investigate the possibility of multiple HAP coverage of a common cell area. In particular we study the uplink system performance since it is considered as a worst case scenario. In order to obtain further enhancement (interference mitigation) we also apply space-time diversity techniques, such as Single-Input Multiple-Output (SIMO) receive diversity or Multiple-Input Multiple-Outp

Leukotriene A4 hydrolase/aminopeptidase (LTA4H) (EC 3.3.2.6) is a bifunctional zinc metalloenzyme with both an epoxide hydrolase and an aminopeptidase activity. LTA4H from the African claw toad, Xenopus laevis (xlLTA4H) has been shown to, unlike the human enzyme, convert LTA4 to two enzymatic metabolites, LTB4 and another biologically active product Δ(6)-trans-Δ(8)-cis-LTB4 (5(S),12R-dihydroxy-6,1

Subtle changes in the geometric and electronic properties of supported molecules, with a potential impact on the functioning of molecular devices, can typically be imaged by scanning probe microscopy, but their exact origin and nature often remain unclear. Here we show explicitly that the symmetry reduction of iron phthalocyanine upon adsorption on Cu(111) can be observed not only in scanning tunn

Background: Currently, the TNM classification of malignant tumours based on clinicopathological staging remains the standard for colorectal cancer (CRC) prognostication. Recently, we identified the mitochondrial oxidative phosphorylation chain as a consistently overrepresented category in the published gene expression profiling (GEP) studies on CRC prognosis. Methods: We evaluated associations of

Popular Abstract in Swedish Känselinformation (sensorisk information) från nacken har stor betydelse för rumsorienteringen. För att kunna detektera kroppsrörelser korrekt och därigenom bibehålla balansen krävs ett samspel mellan nackens sensoriska information tillsammans med kroppens övriga led- och muskelsinnen (proprioceptionen), balansapparaterna i inneröronen (vestibularisorganen), synen samt The overall aim of the work was to examine the influence of cervical biomechanical conditions on movement performance, to study musculoskeletal findings accompanying possible cervicogenic dizziness and to evaluate the influence of cervical proprioception on head orientation. Two devices, measuring cervical range of motion, were compared: Myrin, an inclinometer/compass method and Zebris®, a 3-dime

One classical feature of cancer cells is their metabolic acquisition of a highly glycolytic phenotype. Carbon monoxide (CO), one of the products of the cytoprotective molecule heme oxygenase-1 (HO-1) in cancer cells, has been implicated in carcinogenesis and therapeutic resistance. However, the functional contributions of CO and HO-1 to these processes are poorly defined. In human prostate cancers

Felaktigt val av reparationsmetod och reparationsmaterial medför ofta att livslängden hos reparationen blir alltför kort. För att undvika detta måste man ta stor hänsyn till skadeorsaken och till de aktuella miljöpåfrestningarna. Stor hänsyn måste även tas till den skadade konstruktionens återstående kvalitet. I rapporten görs en genomgång av vilka krav som måste ställas på en reparation av olik

Background. For Diffuse large B-cell lymphoma (DLBCL), the International Prognostic Index is the major tool for prognostication and considers an age above 60 years as a risk factor. However, there are several indications that increasing age is associated with more biological complexity, resulting in differences in DLBCL biology depending on age. Methods. We conducted a registry-based retrospective

Acute Pancreatitis (AP) is an inflammation disease that characterized by activation of protease and the innate immune system, leading to infiltration of neutrophils and tissue damage in the pancreas. The aim of this thesis was to determine the role of isoprenylation (farnesyltransferase and geranylgeranyltransferase) as well as NET formation in regulating recruitment of neutrophils and tissue dama