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3-Substituted indoles and their analogues - hetero condensed pyrroles (hetero-indoles) - have been synthesised by two different palladium-catalysed reactions: a) A series of 2-silylated 3-substituted (hetero-)indoles have been prepared by palladium-catalysed coupling between o-iodo(het)arylamines and silyl substituted internal acetylenes. The outcome of the reaction was found to depend on the typ
Foreign entry mode choices are decisions of paramount importance for the long-term survival and growth of companies that are in a process of rapid international expansion. In this article we seek to understand the foreign market channel strategies of Born Globals. We examine whether these companies develop a similar strategy regarding foreign entry mode choices and if their market channel strategi
In the search for new pharmaceutically active compounds, it is recognized that Nature produces structurally different compounds in a great variety. By having the compounds or extracts tested in defined systems, new drugs or more often leads (a compound that has an interesting but moderate activity) can be found. When a lead is found, structurally similar compounds with modified functional groups a
Technology change will have a central role in achieving a sustainable energy system. This calls for methods of analysing the dynamics of energy systems in view of technology change and policy instruments for effecting and accelerating technology change. In this thesis, such methods have been developed, applied, and assessed. Two types of methods have been considered, methods of analysing and proje
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Social anxiety disorder (social phobia) is a debilitating and common anxiety disorder, with a lifetime prevalence ranging from 6 % to 12 %. The condition has its onset in childhood and early adolescence, affects females more often than males, and if untreated is associated with high risk of developing comorbid anxiety and mood disorders, as well as substance abuse. The increasingly growing body of
