Alternative Explanations for "Multistate" Kinetics in Protein Folding: Transient Aggregation and Changing Transition-State Ensembles
Deviations from classical two-state kinetics in protein folding need not always be explained by the presence of rapidly formed intermediates. In some cases, such deviations are caused by short-lived aggregates whereas in other cases they arise from changes of the position of the transition state. These are two new facets of the mechanism of two-state folding. The first part of this account describ
