Filetype
Capsazepine and similar compounds, capsazepinoids, were shown to be general inhibitors of agonist (leukotriene D4, histamine, acetylcholine, prostaglandin D2) evoked constriction of human small airway preparations. The mechanism of action remains to be elucidated, but established bronchodilator principles, e.g. beta2-adrenoceptor agonism, as well as TRPV1 antagonism were shown to be less likely. F
This thesis presents the developement and verification of cutting force models for multi-toothed cutting processes. The scope of the thesis includes the modelling and measuring of factors that affect the mechanical load variation between individual cutting edges in the process. These factors will for example influence tool life and workpiece quality. The most important factors are; errors in radia
The aim of these studies has been to investigate what information that can be obtained on gel-emulsions with nuclear magnetic resonance, NMR, as the investigating tool. The gel-emulsions are important in many technical applications such as in food products, in cosmetic and pharmaceutical formulations, and in emulsion explosives, just to name a few applications. We have worked with the NMR diffusom
The rapid development of computer-based design analysis tools and methods such as the finite element method (FEM) within computational structural mechanics (CSM), computational fluid dynamics (CFD), and multi-body systems (MBS) during recent decades has fundamentally changed the way in which products are designed and developed. Among the many advantages observed in industrial practice, one can men
The development of immature progenitor cells into highly differentiated effector cells is a process central in modern medicine with applications in the fields of cell therapy as well as oncology. This thesis is focused on the molecular mechanisms that control the development of B lymphocytes. This is a complex and tightly regulated process involving several stages proceeding from stem cells to ant
Hydrophobic pervaporation has gained a lot of attention as an alternative process for mild aroma recovery, but the real commercial applications of this process are still in their infancies. Better understanding of mass transport phenomena in composite pervaporation membranes is essential from the point of view of membrane manufacturing, while process simulation is an important tool for predicting
Different models and statistical mechanical approximations for titrating polyelectrolytes are studied and the results compared with Monte Carlo simulations and experimental data. Three types of models have been used in the simulations: i) rigid structures and freely jointed chains with ii) rigid bonds and iii) flexible, harmonic bonds. Sampling is facilitated for the latter two by the use of pivot
This thesis presents the research performed within two different research groups using heavy-ion induced nuclear reactions. They offer the opportunity to investigate different properties of nuclear matter. The results are based on measurements using a variety of different experimental techniques. The PHENIX experiment measured the production of deuteron and anti-deuterons at mid-rapidity in gold-
The search for polymeric materials with new property profiles has stimulated a great interest into polymer blends and reactive processing. During recent years many new blends have reached the market. Although some of these are homogeneous mixtures of polymers, most commercial blends are composed of immiscible polymers, and contain two or more polymeric phases. The properties of such blends depend
The most central question in the strategic management literature is why some firms are more successful than others, often expressed as an aim to understand sources of competitive advantage. In this thesis, an empirical observation is made that a number of manufacturing plants belonging to the same firm show sustainable differences in financial success, and the question is why. The main theoretical
The aim of this study is to contribute to an increased understanding of the demands that the operation’s character places on management control. The study’s point of departure is the assumption that management control must be adapted to the operation’s character in order to be able to support strategy implementation and the achievement of objectives (contingency theory). The study deals with the d
The analysis of the recorded electrical activity of the heart during an exercise test is a valuable method for investigating a patient's circulatory and respiratory system. But the disturbances that occurr during a test often make it difficult to interpret the signal in order to detect changes evoked by the increased workload and related to for instance coronary artery diseases. Suppression of dis
The final step in aerobic respiratory pathways is catalyzed by terminal oxidases. Bacteria generally have two or more terminal oxidases. Aerobically grown Bacillus subtilis synthesize three terminal oxidases: one cytochrome c oxidase, cytochrome caa3 and two quinol oxidases, cytochrome aa3 and cytochrome bd. In addition, a fourth cytochrome of bd-type has been predicted from the genome sequence. C
With the discovery of antibiotics, several diseases that were previously lethal is today readily cured, or so we thought. Some degree of resistance to one or several antibiotics can be found among many strains of clinical important bacteria. The problem has been somewhat kept at bay for the last few decades by altering already existing antibiotics, and thereby prolonging their usage. It is clear t
Over the last decades, both force sensors and cameras have emerged as useful sensors for different applications in robotics. This thesis considers a number of dynamic visual tracking and control problems, as well as the integration of these techniques with contact force control. Different topics ranging from basic theory to system implementation and applications are treated. A new interface develo
This thesis concerns a nuclear accident that occurred in the Thule (Pituffik) area, NW Greenland in 1968, called the Thule accident. Results are based on different analytical techniques, i.e. gamma spectrometry, alpha spectrometry, ICP-MS, SEM with EDX and different sediment models, i.e. (CRS, CIC). The scope of the thesis is the study of hot particles. Studies on these have shown several interest
Gas turbines have served as economically profitable and reliable generators of power for the past few decades, and have mainly been used in simple and combined cycles. The increased restrictions on hazardous emissions and the increased demand for profitability have created new prospects for innovative power cycles. The requirements for these new power cycles are substantially better emissions, hig
The combination of laminar flows in microfabricated channels and acoustic forces induced in ultrasonic standing wave fields offers new possibilities for advanced particle and cell manipulation in lab-on-a-chip applications as well as in relatively high throughput applications. Acoustic particle manipulation systems can be used e.g. to separate, wash, sort, trap or distribute particles in microflui
The point of departure of this dissertation is a consideration of the problems in the field of architecture, of conceptualizing and addressing aspects of the complex relationship between architectural form and use. The aim of the thesis is to create conditions for a discussion on architectural design and territorial power relations within the context of everyday life, and more specifically to inve
The general aim of the investigation is to contribute to the development of a theory of change and learning within the working environment. The specific change processes that were examined, emerged from an interactive initiative for change, intending to facilitate an emancipatory development: employees increasing their control of the work situation, thus improving the quality of service. The empir
