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Background: Few longitudinal cohort studies have focused on the impact of substances abused and psychiatric disorders on premature mortality. The aim of the present study was to identify predictors of increased risk of drug related death and non drug related death in substance abusers of opiates, stimulants, cannabis, sedatives/hypnotics, hallucinogens and alcohol over several decades. Methods: Fo
Background: The use of tumour necrosis factor (TNF) blocking agents in psoriatic arthritis (PsA) is increasing, and the SSATG register has followed patients with PsA for more than 5 years. The aim of the present work therefore was to present efficacy and tolerability data of TNF-blocking agents on PsA in clinical practice, and to study potential predictors for drug survival (the length of time a p
Introduction: Our understanding of how comorbid diseases influence health-related quality of life (HRQL) in patients with chronic obstructive pulmonary disease (COPD) is limited and in need of improvement. The aim of this study was to examine the associations between comorbidities and HRQL as measured by the instruments EuroQol-5 dimension (EQ-5D) and the COPD Assessment Test (CAT). Methods: Infor
BACKGROUND: Previous studies indicate that analysis of the ST waveform of the fetal electrocardiogram provides information on the fetal response to hypoxia. We did a multicentre randomised controlled trial to test the hypothesis that intrapartum monitoring with cardiotocography combined with automatic ST-waveform analysis results in an improved perinatal outcome compared with cardiotocography alon
Symptoms of fecal incontinence and constipation are common in the general population. These can, however, be unreliably reported and are poorly discriminatory for underlying pathophysiology. Furthermore, both symptoms may coexist. In the elderly, fecal impaction always must be excluded. For patients with constipation, colon transit studies, anorectal manometry and defecography may help to identify
The role of environmental permits as a driver for environmental improvements has been a topic of debate for a while. Many permitting regulations were designed in the 1970's and have not been updated since then. Consequently, they have acted mostly as a driver for the adoption of pollution control technologies. Some experts now see that appropriately designed and implemented environmental permi
The purpose of this thesis is to create a greater understanding of relationships and networks on regulated markets. This includes what the climate are like on such a market and how different aspects within relationships and networks are affected by regulations. By the use of a deductive approach, a qualitative study was performed. This was carried out by interviewing different actors on the Swedis
Amidst debates on the potential adverse consequences of high-technology industries on employment, it is imperative to gain a deeper understanding of how high-tech industries shape labour markets outcomes across various socio-economic, institutional, and geographical contexts. This thesis seeks to contribute to this understanding by estimating the impact of high-technology industries on employment
Background/introduction: E-commerce is becoming a natural part of retail business. In order to achieve a competitive edge, companies are shifting to omni channel retailing where channel integration is explored in the search for potential improvements in connection with customer offer and costs. One solution is to integrate inventories and offer improved order fulfilment by using both warehouse and
