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Dual-mobility cups in THA were designed to reduce prosthesis instability and the subsequent risk of revision surgery in high-risk patients, such as those with hip fractures. However, there are limited data from clinical studies reporting a revision benefit of dual-mobility over conventional THA. Collaboration between anthroplasty registries provides an opportunity to describe international practic

Bröstcancer är vanligt förekommande bland kvinnor, en av tio kvinnor får en bröstcancerdiagnos under sin livstid. Upplevelsen av bröstcancer är en komplex process, som innebär ett flertal sammanlänkade stressfulla händelser. Det är därför tydligt att sättet personen reagerar på sådana stressorer kan ha en betydande påverkan på både fysisk och psykisk hälsa. Resiliens är ett konstrukt som innefattaBreast cancer is a common event among women, one in ten women receiving a breast cancer diagnosis in their lifetime. The experience of breast cancer is a complex process that entails a multitude of interlinked potentially highly stressful events. It is thus evident that the manner in which one reacts to such stressors can have a substantial impact on both physical and mental health. Resilience is

Aims/hypothesis: Using a targeted proteomics approach, we aimed to identify and validate circulating proteins associated with impaired glucose metabolism (IGM) and type 2 diabetes in a Black South African cohort. In addition, we assessed sex-specific associations between the validated proteins and pathophysiological pathways of type 2 diabetes. Methods: This cross-sectional study included Black So

Type 2 diabetes (T2D) is characterised by defective insulin exocytosis from the pancreatic β cells, accompanied by insulin resistance. Reduced β cells mass is often seen in T2D individuals, caused by enhanced β cells apoptosis. It is now understood that several components drive β cells dysfunction and apoptosis. These are glucose-and lipo-toxicity, ER stress, pro-inflammatory cytokines, dysfunctio

Climate changes, tightly linked to anthropogenic activities, are significantly altering environments and ecosystems globally, such as by increasing marine and coastal deoxygenation or occurrences of extreme weather events. The significance of paleoenvironmental and -climate reconstructions, as well as monitoring of current conditions, for unravelling baseline natural variation, today’s changes and

Kraft black liquor (KBL) is a side-stream that is produced during the kraft pulping process, and mainly contains lignin, hemicelluloses, and cooking chemicals, namely sodium hydroxide and sodium sulphide. KBL is usually evaporated and burned in a recovery boiler in order to recover the cooking chemicals and generate energy. However, pulp mills are sometimes limited by the capacity of their recover

In the field of operations and supply chain management (OSCM), the customer order decoupling point (CODP) hasi been recognized as an important strategic parameter for roughly 30 years. It is the point in the value chain where forecast-driven material flows get separated from order -driven material flows. Despite its long history in the field, multiple calls for further consideration of the CODP inIn the field of operations and supply chain management (OSCM), the customer order decoupling point (CODP) hasbeen recognized as an important strategic parameter for roughly 30 years. It is the point in the value chain whereforecast-driven material flows get separated from order-driven material flows. Despite its long history in the field,multiple calls for further consideration of the CODP in OSCM

Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a heterogenous autoimmune disease. While traditionally stratified into two conditions, granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), the subclassification of ANCA-associated vasculitis is subject to continued debate. Here we aim to identify phenotypically distinct subgroups and develop a da

IMPORTANCE: For individuals without a family history of colorectal cancer (CRC), colonoscopy screening every 10 years is recommended to reduce CRC incidence and mortality. However, debate exists about whether and for how long this 10-year interval could be safely expanded.OBJECTIVE: To assess how many years after a first colonoscopy with findings negative for CRC a second colonoscopy can be perfor

Fear of falling (FOF) is common in persons with Parkinson’s disease (PD) and may have large consequences in daily life, causing a sedentary lifestyle, social isolation and reduced quality of life. FOF is therefore an important aspect to consider for researchers as well as clinicians and the rehabilitation team. Adequate and high quality rating scales are needed to be able to accurately assess FOF

Type 2 diabetes is characterized by hyperglycemia due to insulin resistance in the target tissue and insufficient insulin secretion from the beta cells. Finding new mechanisms and pathways involved in the regulation of insulin secretion from the pancreatic beta cells is of great importance. Our group has earlier found, miRNA-212 and miRNA-132 to be upregulated in the non-obese type 2 diabetic GK r

Idag används årligen över 2 miljoner ton bekämpningsmedel (BM) i världen. Avdessa står Sverige för drygt 9000 ton, eller knappt en halv procent. Den häravhandlingen handlar om att ta fram metoder för att bestämma rester av vissabekämpningsmedel i kroppsvätskor (urin) hos människor och sedan användametoderna för att mäta exponering för bekämpningsmedlen i en befolkningsgrupp. Arbetet är en del av fAlmost every human is exposed to pesticides, in work environments, by domestic use and via diet, drinking water and personal products. Current research expresses concern that low dose exposure over time can lead to adverse health effects. It is therefore important to biomonitor exposure to pesticides in different groups, especially vulnerable groups such as pregnant women. However, there is a gene

Alternative fuels for combustion engines are becoming increasingly popular as society is pushing to phase out fossil energy to reduce CO2 emissions. The compression ignition (CI) engine has a high overall efficiency which makes it a valuable option for the transport fleet, despite the well known NOx and soot pollutants it emits. These two pollutants are emitted due to a combination of high local cAlternative fuels for combustion engines are becoming increasingly popular as society is pushing to phase out fossil energy to reduce CO2 emissions. The compression ignition (CI) engine has a high overall efficiency which makes it a valuable option for the transport fleet, despite the well known NOx and soot pollutants it emits. These two pollutants are emitted due to a combination of high local c

Importance: Different brain regions appear to be involved during β-amyloid (Aβ) accumulation in Alzheimer disease (AD), but a longitudinally valid system to track Aβ stages in vivo using positron emission tomography (PET) is lacking. Objective: To construct a longitudinally valid in vivo staging system for AD using amyloid PET. Design, Setting, and Participants: Longitudinal multicenter cohort stu

IMPORTANCE: Visual assessment of amyloid positron emission tomographic (PET) images has been approved by regulatory authorities for clinical use. Several immunoassays have been developed to measure β-amyloid (Aβ) 42 in cerebrospinal fluid (CSF). The agreement between CSF Aβ42 measures from different immunoassays and visual PET readings may influence the use of CSF biomarkers and/or amyloid PET ass

STUDY QUESTION: What is the relationship between the number of oocytes collected in fresh IVF treatments and the likelihood of cumulative delivery rate (fresh and frozen) per oocyte aspiration, severe ovarian hyperstimulation syndrome (OHSS) and thromboembolic events? SUMMARY ANSWER: Cumulative delivery rate per aspiration increases up to 20 oocytes retrieved and then evens out while the incidence

SummarySustainable sewage sludge management has been a heavily debated topic in Europe for more than a decade. Due to its content of pollutants such as heavy metals, pharmaceuticals and other organic micropollutants, the use of sewage sludge for farmland application is currently banned or restricted in most European countries. Therefore, alternative methods for sludge management are discussed. The