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Importance: There are limitations in current diagnostic testing approaches for Alzheimer disease (AD). Objective: To examine plasma tau phosphorylated at threonine 217 (P-tau217) as a diagnostic biomarker for AD. Design, Setting, and Participants: Three cross-sectional cohorts: an Arizona-based neuropathology cohort (cohort 1), including 34 participants with AD and 47 without AD (dates of enrollme
My research engages with the varieties of relationship between verbal and non-verbal forms of language and communication. I approach the issue through three people who live or work with non-verbal people on the autistic spectrum: Phoebe Caldwell, Fernand Deligny and Iris Johansson. Their practices bring singular perspectives to my core question: How can we (re)conceive and engage with non-verbal f
Background: Most patients with Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies do not carry mutations in known disease-causing genes. The aim of this study was to identify a novel gene implicated in the development of these disorders. Methods: Our study was done in three stages. First, we did genome-wide linkage analysis of an Italian family with dominantly inherit
Vad står vi på – hur tar man reda på det? Kanske man kan titta på en geologisk karta, borra ett hål eller gräva en grop? Det kan gå bra, men ibland finns det inte tillräckligt detaljerade kartor och att gräva upp allt man är intresserad av är ingen lysande idé. Tänk om man kunde forska fram en metod som gör att man kan se rakt igenom marken, som röntgenundersökningar på sjukhus! På sätt och vis kaWhat would you find below your feet – how do you find out? Perhaps you could look at a geological map, drill, or dig? That could work, but sometimes the maps are not detailed enough, and digging everywhere to find out is impractical. Imagine if you could develop a method that allows you to see straight through the ground, as x–rays through the body! To some extent, such methods already exist; you
Diabetes is associated with devastating chronic complications including coronary heart disease and stroke (macrovascular complications) as well as microvascular disorders leading to damage of the small vessels and the development of retinopathy, nephropathy and neuropathy. The underlying pathogenesis is not clear, but hyperglycemia has been identified as an important risk factor. Previous work fro
Representing an international, multi-institutional research team, the panel presents a theoretical framework for understanding what prompts academic staff/faculty to change towards sustained use of pedagogies that make a meaningful difference in student learning. The theory grows out of a synthesis of literature on: the role of leadership and resources in emerging changes to teaching practices (Gi
What can we learn by transmitting electrical currents through electrodes in the ground? Geophysical methods can help us to locate the bedrock, valuable mineral ores, remains of ancient buildings and many other secrets hiding below the surface. However, it is not only the universal interest for the unknown that drives the geophysical research forward. Knowledge of, for example, fractured bedrock, c
Space structures are a leaf taken from Nature. Natural forms possess exceptional rigidity and use minimum materials to maximum structural advantage. To quote Makowski, "Natural forms act in the direction of minimum effort". Man has not been slow in copying these examples drawn from Nature. The main structural aim which drives the use of this construction system is to use the least materi
Title Geothermal Energy Solution at IKEA in Malmö Visualization and monitoring of geothermal energy at IKEA in Malmo concerning 2009-2011 Author Magdalena Horn Environmental Engineering towards Energy Systems Analysis, Lund University Tutors Dr Patrick Lauenburg, Department of Energy Lund University - Lund Institute of Technology Anna Ekdahl, Sweco Environment Tobias Malmgren, IKEA Properties Prob
Importance: Alzheimer disease (AD) pathology starts with a prolonged phase of β-amyloid (Aβ) accumulation without symptoms. The duration of this phase differs greatly among individuals. While this disease phase has high relevance for clinical trial designs, it is currently unclear how to best predict the onset of clinical progression. Objective: To evaluate combinations of different plasma biomark
Det rapporteras många fall och spenderas årligen stora mängder av resurser på vattenskador i byggnader i Sverige. Vattenskador som uppkommer på grund av läckage och utströmning av vatten från installationer så som tappvatten-, avlopp- och värmesystem, utrustning så som kylskåp, frysar och diskmaskiner samt läckande tätskikt i våtrum. Vattenskador från dessa system orsakar allvarliga problem i bygg
Free movement of goods, capital, workers and services have stimulated economic and social interaction between Member States of the European Union. At the same time international trade and globalization go far beyond the scope of the EU and have a tremendous impact on various countries in the world. Capital mobility encourages companies to look for business opportunities world-wide in order to meet
Under det senaste seklet har det svenska samhället utvecklats från att ha varit ett industrisamhälle till att bli ett kunskapssamhälle. Denna utveckling har inneburit att s.k. kunskapsföretag har kommit att få en alltmer central roll i samhället. Kunskapsföretag kännetecknas av att de främst bedriver kunskapsproduktion och inte materiell produktion. Det är de anställdas kunskap som utgör kunskapsf
Uppsatsens syfte är att undersöka konkurrensklausulers utformning och verkan, med särskilt fokus på skälighetsbedömningen av sådana klausuler. I uppsatsen används en traditionell rättsvetenskaplig metod. Då rättsläget i viss mån är outrett beträffande arbetsgivarens rätt att ensidigt begränsa eller frånträda en konkurrensklausul, har empiriskt material använts gällande dessa frågeställningar. FrågThe purpose of this essay is to examine the content and effect of non-competition clauses, with a particular focus on the fairness of these clauses. To examine this a traditional legal method is used. Though some aspects are unclear regarding the legal situation concerning the right for an employer to unilaterally reduce and withdraw from a non-competition clause, interviews have been used to exam
Title: Discussing the motivation of knowledge workers to engage in employee driven innovation – the influence of trust in organisational processes Date of the seminar: June 3rd 2014 Course: Master Corporate Entrepreneurship and Innovation Internship and degree project (Master thesis 15 ECTS) Authors: Sam Hobbs & Julien Véron Supervisor: Håkan Lagerquist Keywords: Motivation, trust, employ
Det internationella skattesamarbetet har under en längre tid definierats av en vilja att motarbeta dubbelbeskattning av enskilda skattebetalare. Det främsta sättet på vilket detta har tagit uttryck är de många bilaterala skatteavtalen som finns mellan olika stater idag. I ett sådant avtal regleras beskattningen av en gränsöverskridande transaktion eller affärsverksamhet mellan de två avtalsslutandThe international tax law system has for a long time been defined by its prevention of double taxation of the taxpayers. The main way in which this work has been undertaken has been the many bilateral tax agreements that exist between states today. These agreements regulate the taxation rights between two states in a case of a cross-border transaction or arrangement. In that way it is possible for
Kapitalförsäkringar är idag en schablonbeskattad sparform. Tillgångar som innehas på en kapitalförsäkring som ges ut av ett svenskt livförsäkringsbolag ägs av och beskattas hos försäkringsbolaget. Försäkringstagaren, som antingen kan vara en fysisk eller en juridisk person, debiteras löpande för tillgångarna i försäkringen genom att en schablonberäknad intäkt beskattas med avkastningsskatt. En ann
Corrugated galvanized iron (CGI), or corrugated sheet metal, is a lightweight roofing material that was invented in the early 1800s. The corrugation gives the steel an increased flexural strength in its installed direction and thus increases the amount of load the CGI-plate is able to carry and the span it can be effective at. Thanks to its light weight, corrugated sheet is one of the most commonl
