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Background: Homologous recombination (HR) deficiency (HRD) is prevalent in ovarian, prostate, and specific subgroups of breast cancer, particularly triple-negative breast cancer (TNBC). Tumor HRD status can be inferred through DNA-based, RNA-based, functional, or image-based approaches. A comprehensive evaluation of the concordance and discordance among HRD prediction methods derived from these di
