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INTRODUCTION: Since the last two decades, there has been a dramatic rise in caesarean sections (CS) throughout the world. This increase has been seen even in Europe, where rates vary significantly from 17% in Northern Europe to 56% in the South. Although, CS can be a lifesaving intervention when medically necessary, non-essential CS are associated with short- and long-term complications for both t

Introduction: Doxorubicin (DOX), a potent anthracycline, is widely used in cancer therapy, but its effect is limited by doxorubicin-induced cardiotoxicity (DIC). Increasing evidence suggests that DIC is associated with ferroptosis, a cell death characterized by the iron-dependent accumulation of lipid peroxides. Although aerobic exercise is recommended for chemotherapy-related cardiac dysfunction,

Traffic-related air pollution has severe implications for our health and stringent emission legislation is being enforced to traffic emissions, for example in the EU, USA, and China. With stricter emission legislation (next is EURO 7) and a rapid growth of battery electrical vehicles (BEVs) the combustion-derived pollutants emitted from the tailpipe are decreasing. However, heavier vehicles have r

Urban areas play an important role in attaining the sustainability and energy goals set by municipalities. Despite the often ambitious sustainability visions and goals for new urban areas, there is limited understanding of how these aspirations are integrated into the planning and development process. This paper aims to provide insights into how energy-related visions and goals, in a new district

Background: Human immunodeficiency virus type 1 (HIV-1) is one of the fastest-evolving human pathogens. Understanding HIV-1 transmission, within-host adaptation, and evolutionary dynamics is pivotal for development of interventions and vaccines. HIV-1 infection is generally caused by a single transmitted founder virus (TFV), and TFV sequences are typically obtained using single genome amplificatio

Importance Identifying early proteomic profiles in infants who develop severe retinopathy of prematurity (ROP) may reveal targets for preventive interventions to reduce retinal vessel loss and the subsequent risk of severe ROP. Objective To assess early longitudinal profiles of blood protein levels in preterm infants with or without severe ROP and the effect of arachidonic acid (AA) and docosahexa

BACKGROUND: Preventing infection in primary sutured perineal tears after childbirth is crucial to avoid systemic antibiotic use and potential complications from poor healing. This study aimed to investigate the efficacy of an antibacterial, triclosan-coated suture (VicrylPlus ®) in reducing infection in primary sutured childbirth-related perineal tears. METHODS: The PLUS study was a single-cente

Research topic/aim:The purpose of this paper is to contribute empirically to the ongoing academic discussion about the meaningful implementation of narrative art as a pedagogical tool in professional ethics education (PEE). In the present work, meaningfulness is conceived of as connectedness, and narrative art includes literary fiction and autobiography. Research questions are:How do students in e

BACKGROUND: Leukocytes have been reported to have tumor stimulating effects in colorectal cancer, among other malignancies. In line with this, earlier research has shown improved disease-free survival in patients with postoperative neutropenia compared to non-neutropenic patients following cytoreductive surgery (CRS) and hypertherm intraperitoneal chemotherapy (HIPEC).AIM: To evaluate the impact o

Background: Adverse pregnancy outcomes, such as preterm delivery and hypertensive disorders of pregnancy, may be associated with higher future risks of heart failure (HF). However, the comparative effects of different adverse pregnancy outcomes on long-term risk of HF, and their potential causality, are unclear. OBJECTIVES: The authors sought to examine 5 major adverse pregnancy outcomes in relati

Due to the large extent of seawater surface over the globe, aerosol particles spend significant time being transported over this type of surface. Therefore, global aerosol circulation is largely impacted by the processes particles undergo during long-range transport overseas. In this study, we investigated submicron aerosol (PM1) chemical composition changes during long-range transport events over

Aims/hypothesis: An intronic variant (rs10830963) in MTNR1B (encoding the melatonin receptor type 2 [MT2]) has been shown to strongly associate with impaired glucose regulation and elevated type 2 diabetes prevalence. However, MTNR1B missense variants have shown conflicting results on type 2 diabetes. Thus, we aimed to gain further insights into the impact of MTNR1B coding variants on type 2 diabe

Background: Women who deliver pre-term have been reported to have increased future risks of cardiometabolic disorders. However, their long-term risks of ischemic heart disease (IHD) and whether such risks are due to shared familial factors are unclear. A better understanding of these risks may help improve long-term clinical follow-up and interventions to prevent IHD in women. Objectives: The purp

Trots likadana tekniska förutsättningar visade den aktuella avhandlingen på att energianvändningen varierade stort mellan hushåll – vilket även tidigare forskning pekat på. Det skiljde en faktor två till tre mellan högsta och lägsta energianvändningen för de grupper av likadana hus som studerades. Skillnaden i vattenanvändning var ännu större, nämnare bestämt en faktor sex. De boendes val och vardTo achieve global energy goals, energy use in residential buildings must decrease. The implementation of technical measures is crucial but alone it is not sufficient; residents need to change their behaviour as well. However, households are not a homogeneous group in terms of their energy use and behaviour; rather, the use varies between households and over time. To promote energy savings in build

Prostatacancer är den vanligaste cancern bland män i Sverige. Varje år insjuknar ca 10 000. Sjukdomen är starkt åldersberoende och är mycket vanlig bland äldre män. Latent cancer (icke kliniskt signifikant) förekommer ofta. Sjukdomen klassificeras som låg, mellan eller högrisk baserat på Gleason summa (tumörens aggressivitet), stadium och PSA. Val av behandling sker utifrån riskgrupp och ålder. Lå

AbstractThe primary purpose of understanding disease etiology is to explain how a specific phenotype is determined by genotype. In pursue of this aim, exploring the diversity in DNA sequence variants that affect biomedical traits, especially those related to the onset and progression of genetically determined human disease. The human leukocyte antigens (HLA) are highly polymorphic cell surface pro