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Background Plasma triglyceride levels are heritable and are correlated with the risk of coronary heart disease. Sequencing of the protein-coding regions of the human genome (the exome) has the potential to identify rare mutations that have a large effect on phenotype. Methods We sequenced the protein-coding regions of 18,666 genes in each of 3734 participants of European or African ancestry in the

Metabolic syndrome and diabetes impact brain function and metabolism. While it is well established that rodents exposed to diets rich in saturated fat develop brain dysfunction, contrasting results abound in the literature, likely as result of exposure to different high-fat diet (HFD) compositions and for varied periods of time. In the present study, we investigated alterations of hippocampal-depe

Diabetes affects the morphology and plasticity of the hippocampus, and leads to learning and memory deficits. Caffeine has been proposed to prevent memory impairment upon multiple chronic disorders with neurological involvement. We tested whether long-term caffeine consumption prevents type 2 diabetes (T2D)-induced spatial memory impairment and hippocampal alterations, including synaptic degenerat

There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The analysis included 476,160 participants, recruite

Individuals with mental illness and a contemporary substance addiction has been more and more noticed within social work and issues on interaction between different instances that have a mutual responsibility for the individual has been illuminated within research. It has shown that the goal of interaction between for example Social Services and the Psychiatry has been difficult to achieve. We hav

Författare: Marie Isaksson Titel: Undermedveten kunskap i socialt arbete Handledare: Anders Lundberg Examinator: Anders Östnäs Syftet med uppsatsen har varit att undersöka vad den undermedvetna dimensionen av socialarbetarens kunskapsbas består av. Denna undermedvetna dimension är avgränsad till att fokusera på filosofen och vetenskapsmannen Michael Polanyis tankar kring att all kunskap bygger påAuthor: Marie Isaksson Title: Subconscious knowledge in social work Supervisor: Anders Lundberg Assesor: Anders Östnäs The purpose of the essay has been to investigate what the subconcious dimension of the social worker's knowledge base consists of. This tacit dimension is limited to focusing on the philosopher and scientist Michael Polanyis thoughts on that all knowledge is based on a subcon

Experienced safety is difficult to measure, as it treats subjective feelings and these do not always coincide with crime rates. In addition, women, immigrants and poor people often report lower levels of experienced safety, which implies structural causes. Many quantitative studies have been carried out on the subject of safety, crime and fear but there is still a need for more knowledge of experi

Background: When cannulation is challenging during endoscopic retrograde cholangiopancreatography (ERCP), and the standard guidewire technique with sphincterotomy is unsuccessful, alternative cannulation techniques can be used to access the biliary tree. The purpose of this study was to compare the incidence of adverse events and cannulation success rates between transpancreatic sphincterotomy (TP

Hormone-sensitive lipase (HSL) is a key enzyme in adipose tissue that hydrolyses stored fat (triacylglycerol). The activity of HSL is under strict hormonal and neural control. Lipolytic agents, such as catecholamines, increase the cAMP levels, resulting in an activation of cAMP-dependent protein kinase (PKA), which in turn phosphorylates and activates HSL. This thesis describes the structural orga

News Archive - Page 15 of 54 - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Evaluation of Programme W

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Mitochondrial dysfunction is implicated in neurodegenerative disorders, such as Alzheimer's disease (AD). Translocase of outer mitochondrial membrane 40 (TOMM40) may be influential in this regard by influencing mitochondrial neurotoxicity. Little is known about the influence of the TOMM40 gene on hippocampal (HC) volume and episodic memory (EM), particularly in healthy older adults. Thus, we sough

Background: Whey protein increases postprandial serum insulin levels. This has been associated with increased serum levels of leucine, isoleucine, valine, lysine, threonine and the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). We have examined the effects of these putative mediators of whey's action on insulin secretion from isolated mouse Langerhans islets. Methods: Mouse p

Background: Epidemiologic evidence of an association between fish intake and type 2 diabetes (T2D) is inconsistent and unresolved. Objective: The objective was to examine the association between total and type of fish intake and T2D in 8 European countries. Design: This was a case-cohort study, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, with 3.99 m

Background: Age-related losses in bone mineral density (BMD), muscle strength, balance, and gait have been linked to an increased risk of falls, fractures and disability, but few prospective studies have compared the timing, rate and pattern of changes in each of these measures in middle-aged and older men and women. This is important so that targeted strategies can be developed to optimise specif

OBJECTIVE-Mutations in the hepatocyte nuclear factor (HNF)-1 alpha, HNF-4 alpha, glucokinase (GCK), and HNF-1 beta genes cause maturity-onset diabetes of the young (MODY), but it is not known whether common variants in these genes predict future type 2 diabetes. RESEARCH DESIGN AND METHODS-We tested 14 previously associated polymorphisms in HNF-1 alpha, HNF-4 alpha, GCK, and HNF-1 beta for associa

Hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in children in the western world. HUS is characterized by the triad of hemolytic anemia, thrombocytopenia and renal failure. There are two main subtypes of HUS; typical or D+ (D stands for diarrhea) HUS associated with enterohemorrhagic E. coli (EHEC) infection, which accounts for about 90% of all HUS cases, and atypic

Tight coupling between cytosolic and mitochondrial metabolism is key for GSIS (glucose-stimulated insulin secretion). In the present study we examined the regulatory contribution of PDH (pyruvate dehydrogenase) kinase 1, a negative regulator of PDH, to metabolic coupling in 832/13 clonal beta-cells. Knockdown of PDH kinase 1 with siRNA (small interfering RNA) reduced its mRNA (>80 %) and protein l