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Introduction: Non-suicidal self-injury (NSSI) is often met with stigma, which can deter individuals from seeking help. While most research on NSSI stigma has focused on clinical settings, the attitudes of those most likely to receive an NSSI disclosure, such as peers, friends, and family, remain underexplored. Building on qualitative findings that positive disclosure experiences can foster support

INTRODUCTION: Maternal blood pressure (BP) is crucial for the health of both mother and fetus, with long-term implications for the child's health. Studies exploring the link between perfluoroalkyl substances (PFAS) exposure and hypertensive disorders of pregnancy often yield inconsistent results, frequently focusing on a single BP measurement rather than longitudinal measurements. This study chara

BackgroundSome patients scheduled for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) only undergo explorative laparotomy (open/close procedure) due to extensive tumor spread or challenges in achieving complete cytoreduction (CC0). This study aimed to evaluate the surgical outcomes and overall survival in patients with peritoneal surface malignancy (PSM) who only

BACKGROUND: Seizure duration during electroconvulsive therapy (ECT) correlates with treatment efficacy and may be influenced by depth of anaesthesia. The Patient State Index (PSi), derived from processed EEG, offers a potential method to monitor depth of anaesthesia during ECT. This study examined the correlation between pre-ictal PSi and EEG-seizure duration.METHODS: In this prospective observati

BackgroundAmbulance clinicians regularly encounter medical, caring, existential and ethical challenges. Meeting patients with complex medical presentations underscore the need for holistic decision-making and actions as ambulance clinicians struggle to strike a balance between addressing medical and caring needs.AimThis study aimed to explore action alternatives considered and discussed during eth

Background: Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify heterogeneity before, at, and after T1D diagnosis, and in response to disease-modifying therapies. Methods: We systematically reviewed PubMed and EMBASE databases (6/14/2022) assessing 10

Background: The objective of this systematic review is to identify prognostic factors among women and their offspring affected by gestational diabetes mellitus (GDM), focusing on endpoints of cardiovascular disease (CVD) and type 2 diabetes (T2D) for women, and cardiometabolic profile for offspring. Methods: This review included studies published in English language from January 1st, 1990, through

Purpose: We aimed to investigate the incidence and clinical features of Streptococcus dysgalactiae peripartum infections (SDPI), and to investigate the distribution of emm-types in relation to disease severity and the genetic relatedness of isolates from hospital clusters. Materials and methods: Patients with growth of S. dysgalactiae in a genital or wound culture, collected between January 2014 a

BACKGROUND: Both hospitalised (H) and non-hospitalised (NH) individuals may have different symptoms and impairments after COVID-19. We aimed to explore symptoms, mental and physical health after initial COVID-19 for both groups of individuals and the association between physical and mental impairments in relation to self-rated health status and to identify different cluster profiles.METHODS: Parti

Today many of us strive to live as climate-friendly lives as possible, we stay informed with the ways that we can contribute and then try to alter our everyday habits accordingly. We often have an idea of what the best choice of transportation would be or that we should reduce our consumption in order to decrease our personal carbon footprint. Even with the best intentions our everyday-related dec

BACKGROUND: Heart failure (HF) is characterized by hemodynamic derangements that are likely to mediate systemic metabolic perturbations but limited data are available. Plasma metabolite profiling provides opportunities for comprehensive investigation of such perturbations. Here, we aimed to characterize plasma profiles that associate with HF and their relationship with central hemodynamics, sympto

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases

OBJECTIVE Chronic subdural hematoma (CSDH) is a common cause of morbidity in the older population and the incidence of CSDH is likely to increase in upcoming years due to the increasing age of the population. Surgical intervention is the cornerstone of treatment, but trials have shown conflicting results regarding the optimal type of surgical drainage. The aim of this study was to compare outcomes

PURPOSE. Epithelial maturation is essential for the specificity and functionality of retinal pigment epithelial (RPE) cell models. This study investigates how different maturation conditions shape RPE characteristics and cellular complement biology in two commonly used in vitro models: ARPE-19 and induced pluripotent stem cell–derived RPE (iPSC-RPE). METHODS. ARPE-19 and iPSC-RPE cells were cultur

Purpose To evade immunosurveillance many cancers convert tryptophan (Trp) into kynurenine (Kyn), which induces immunotolerance and suppresses immune responses. Elevated Kyn amounts have been found in blood from patients with cutaneous melanoma. This study aimed to investigate whether higher Kyn abundance and lower Trp abundance can be detected on the surface of cutaneous melanoma lesions compared

Background and Purpose Plaque rupture is the underlying cause of most cardiovascular events, such as stroke and myocardial infarction. The co-stimulatory molecule LIGHT (tumor necrosis factor superfamily member 14, TNFSF14) has been detected in foam cell-rich regions of atherosclerotic plaques, but whether it has a role in plaque stability is not known. This study investigates the association betw