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Cardiovascular-kidney-metabolic (CKM) syndrome affects approximately 90% of US adults, arising from the convergence of metabolic dysfunction, chronic kidney disease (CKD), and cardiovascular disease (CVD). These conditions create self-reinforcing cycles of multiorgan damage, substantially increasing mortality risk. The American Heart Association’s 2023 staging framework stratifies CKM from stage 0
The 1990s were significant for several events promoting environmental protection and the sustainable use of natural resources. For instance, both the United Nations Conference on Environment and Development in 1992, which stressed the need to stop the overconsumption of natural resources and the United Nations Framework Convention on Climate Change endorsed a framework to combat climate change. Si
The electrification of the transportation sector is a central strategy for decarbonization, yet it raises concerns about the capacity of existing electric power grids to meet increasing demand. This thesis investigates the interaction between large-scale electrified vehicle fleets and the electric power system under the assumption of full transport electrification. The focus is on assessing the re
Collaborative governance networks are increasingly central to local climate action, yet research offers limited understanding of the personal, psychological, and informal factors that sustain engagement within them. This paper examines how such networks facilitate meaningful and lasting participation through an in-depth study of Malmö Works, a long-standing public–private collaboration focused on
The chemokine monocyte chemoattractant protein-1 (MCP-1) plays an important role as chemoattractant for monocytes in atherosclerosis. It is established that MCP-1 is produced by vascular smooth muscle cells, but the underlying mechanisms for its release are not identified. Here, we investigate production and secretion of MCP-1 in primary human coronary artery smooth muscle cells. We demonstrate th
Background: Increasing healthcare demands and a growing nursing shortage contribute to high workloads, psychosocial strain, and risks to care quality. Organisational conditions, job demands, and resources strongly influence nurses’ well-being, retention, and performance. Aim: To examine how nurses balance organisational demands and opportunities, and how these factors relate to work environment, w
Pandemics are a recurring phenomenon that, in addition to their devastating effects on human life and health, have profound economic, social, and political consequences, affecting national and international security. The framing and subsequent management of pandemics by different state actors is therefore an important research topic. Securitization theory has for the past three decades been a cent
Housing preferences in later life vary, and housing decisions are complex. While much attention has been paid to health and accessibility, less is known about how financial factors influence housing decisions among older homeowners. This qualitative study aimed to deepen understanding of how single-family homeowners aged 55 and older reason about their housing situation. We conducted focus groups
Serglycin (SRGN) has been found overexpressed and secreted in glioblastoma (GBM), associated with tumorigenic signaling and poor prognosis. In this study, we aimed to elucidate the involvement of SRGN in the unfolded protein response (UPR), an oncogenic signaling pathway implicated in protein recycling and cell fate. Herein, we developed stably transduced LN-18shSCR GBM cells, expressing high leve
AIM: To investigate serial serum concentrations of procalcitonin (PCT) and C-reactive protein (CRP) in patients treated with mild hypothermia after cardiac arrest, and to study their association to severe infections, post cardiac arrest syndrome (PCAS) and long-term outcome. METHODS: Serum samples from cardiac arrest patients treated with mild hypothermia were collected serially at admission, 2, 6
The Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) clinical trial, including 1,873 patients found an increased risk for cancer with lipid-lowering therapy with ezetimibe/simvastatin 10/40 mg/day, relative to placebo. In a registry-based follow-up study over 21 months from the conclusion of the SEAS trial, new incident cancer and total mortality were investigated in the SEAS study cohort from
