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Antigen presenting cells (APC) have the ability to present both extra-cellular and intra-cellular antigens via MHC class I molecules to CD8(+) T cells. The cross presentation of extra-cellular antigens is reduced in mice with deficient Antigen Peptide Transporter 1 (TAP1)-dependent MHC class I antigen presentation, and these mice are characterized by a diminished CD8(+) T cell population. We have

SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kinases and is highly expressed in adipocytes. We investigated the regulation of SIK2 in adipocytes in response to cellular stimuli with relevance for adipocyte function and/or AMPK signalling. None of the treatments, including insulin, cAMP inducers or AICAR (5-amino-4-imidazolecarboxamide riboside), a

Background World economies increasingly rely on non-standard employment arrangements, which has been linked to ill health. While work and employment conditions are recognized structural determinants of health and health equity, policies aiming to protect workers from negative implications predominantly focus on standard employment arrangements and the needs of workers in non-standard employment ma

This thesis discusses the use of standards in land-use planning risk management regulations. Based on exploring the domains of standards and standardisation, risk science, and risk management regulations, the research contributes significant empirical evidence capturing the perspectives of risk managementpractitioners in terms of the strengths, the weaknesses and the effects of using standards in

The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve well

The purpose is to examine social workers view of vulnerable children and their needs. We are also interested to know how social workers think and discuss concerning the help these children are given. Our main questions in our study are; How do social workers define vulnerable children? Which needs do vulnerable children have according to social workers? Which opportunities and difficulties might t

We chose to study the groups for divorced children in Vellinge municipal because there was no evaluation made of these kinds of groups with the involved methods. Vellinge municipal has had groups for children to divorced parents since 2000. During this period of time the total numbers of children in these groups have expanded. As of now, there are two groups. Our goal with this study was to see

The purpose of this study was to examine and try to understand the physical environment focusing on the fenomena of scribble and damage at a high school. More specifically its aim was to find out how the pupils themselves discribe their physical environment, the reasons why there are scribble and damage at their school and how they are treated by the adults at the school bearing in mind the scribb

The aim of this study was to, using previously collected data from self-declared antisocial behaviour questionnaires, examine if the crime frequency has been different between adolescents that have either been referred to two different forms of open care in social service, child and youth psychiatric inpatient care or have been sent to Homes for Specialised Supervision. The criminality frequency a

This article seeks to re-imagine the Alandish hembygdsrätt to a regional citizenship. Hembygdsrätt is a judicial tool that regulates acquisition of property and voting rights. Its a central part of the autonomy as it constitutes a social-border between Finns and Alanders. However as Åland and Finland became members of the European Union questions arouse concerning the legitimacy of the current st

In this essay we have examined how social workers experience their positions as a public authority person in a society of democracy. As a public officer you have to follow rules and obey the law, which can be difficult if they don't agree with your personal opinion and values. In social work you work with people in a vulnerable situation and it may become extremely demanding to stand between t

The current expansion of mergers and acquisitions forces new postmerged organizational cultures to take form, and requires solid strategies for handling that procedure. Research indicate that at least half of all mergers fail in creating expected synergies, and that the reason for failing is assumed integration issues such as culture clashes. Creating a strong organizational culture is often appoi