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Framing the Problem: Knowledge Brokers in the Multiple Streams Approach

A lot of attention has been focused on the policy stream of the multiple streams framework (MSF). John Kingdon used the role of the policy entrepreneur to theorize what was going on when problems become political issues. In order to fully grasp this process we need to further theorize also the problem stream. What is going on in the problem stream is defining the conditions for coupling done by po

Promoting water-related innovation through networked acceleration : Insights from the Water Innovation Accelerator

The current state of the water and sanitation sector has put water­related innovations high on the global policy agenda. However, the systemic complexity that typically surrounds such contexts call for actionable knowledge of how to enable and orchestrate innovative solutions by connecting different players via organized networks. In this study we explore and analyse the Water Innovation AcceleratThe current state of the water and sanitation sector has put water-related innovations high on the global policy agenda. However, the systemic complexity that typically surrounds such contexts call for actionable knowledge of how to enable and orchestrate innovative solutions by connecting different players via organized networks. In this study we explore and analyse the Water Innovation Accelerat

Insulin resistance probability score and incident cardiovascular disease

Background: Insulin resistance (IR) is associated with cardiovascular disease (CVD). However, insulin immunoassay variability and scarce research of the elderly have hindered the adoption of IR assessment for CVD prevention. We asked whether the probability of having IR [p(IR)]—derived from insulin and C-peptide mass-spectrometry assays—was associated with CVD in the elderly. Methods: A random coh

Gut hormone-based pharmacology : novel formulations and future possibilities for metabolic disease therapy

Glucagon-like peptide-1 (GLP-1) receptor agonists are established pharmaceutical therapies for the treatment of type 2 diabetes and obesity. They mimic the action of GLP-1 to reduce glucose levels through stimulation of insulin secretion and inhibition of glucagon secretion. They also reduce body weight by inducing satiety through central actions. The GLP-1 receptor agonists used clinically are ba

Structural and Functional Analysis of the ApolipoproteinA-I A164S Variant.

Apolipoprotein A-I (apoA-I) is the main protein involved in the formation of high-density lipoprotein (HDL), it is the principal mediator of the reverse cholesterol transfer (RCT) pathway and provides cardio-protection. In addition to functional wild-type apoA-I, several variants have been shown to associate with hereditary amyloidosis. In this study we have performed biophysical and biochemical a

Lighting control systems in individual offices at high latitude: measurements of electricity savings and users preferences

Abstract in UndeterminedAn efficient lighting control systems (LCS) should take advantage of the natural light available, but this presents some technical challenges as well as user related issues. So far, the assessment of lighting energy consumption of LCS has been based on technical features rather than the occupants’ acceptance.This article presents the results of a monitoring study providing