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Obesity is a risk factor for type 2 diabetes (T2D); however, not all obese individuals develop the disease. In this study, we aimed to investigate the cause of differential insulin secretion capacity of pancreatic islets from donors with T2D and non-T2D (ND), especially obese donors (BMI ≥30 kg/m2). Islets from obese donors with T2D had reduced insulin secretion, decreased β-cell exocytosis, and h
Abstrakt Hantverksbryggerinäringen på Gotland är särskilt vital och omtalad från ett nationellt perspektiv, men innehar inte desto mindre en betydande utvecklingspotential. Syftet med denna studie har varit att skapa en nulägesbild över samt identifiera och analysera nyckelaktörer i hantverksölens värdekedja på Gotland. Analysen stödjer sig på en internationell forskningsöversikt, Michael Porter’
BACKGROUND: The prevalence of diabetes is high and increasing. Periodontitis has been identified as a risk factor in both type 1 and 2 diabetes. The study purpose was to assess periodontal conditions, retinopathy, and serum glutamic acid decarboxylase antibody (GADA) titers in relation to retinopathy in individuals with Type 1 Diabetes (T1D).METHODS: The study is a case series. Adult individuals w
Objective. Involvement of the gastrointestinal (GI) tract is a rare complication of granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). The aim was to describe frequency, diagnosis, treatment, and outcome of GI disease in a large series of patients in a single center. Methods.A database that includes all patients with GPA and MPA diagnosed since 1997 in a defined area of sou
OBJECTIVES: Atherothrombosis in the carotid arteries is a main cause of ischemic stroke and may depend on plaque propensity to complicate with rupture or erosion, in turn related to vulnerability features amenable to in vivo imaging. This would provide an opportunity for risk stratification and-potentially-local treatment of more vulnerable plaques. We here review current information on this topic
Policy (or political) entrepreneurship (PE) is an actor-based framework to examine and understand policy change. Rooted in Kingdon’s (1984/2003) Multiple Streams approach (MSA), the policy entrepreneur is defined as “a special kind of actor, embedded in the sociopolitical fabric, who is alert to opportunities and acts upon them; he or she amasses coalitions for the purpose of effecting change in
Worldwide, racial and ethnic minorities have been disproportionately impacted by COVID-19 with increased risk of infection, its related complications, and death. In the initial phase of population-based vaccination in the United States (U.S.) and United Kingdom (U.K.), vaccine hesitancy may result in differences in uptake. We performed a cohort study among U.S. and U.K. participants who volunteere
Severe obesity in adolescence profoundly impacts health and social well-being. Lifestyle modifications are seldom successful in maintaining sufficient weight loss to mitigate the risk of complications. Metabolic and bariatric surgery (MBS) is a standard treatment for adult patients and has emerged as an option for adolescent patients. Several high-quality studies of adolescent MBS show substantial
Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are high-risk factors of diabetes development and may be caused by defective insulin secretion in pancreatic beta-cells. Glucose-stimulated insulin secretion is mediated by voltage-gated Ca2+ (CaV) channels in which the gamma-4 subunit (CaVγ4) is required for the beta-cell to maintain its differentiated state. We here aim to explo
Nature-based solutions (NBS) attract a growing interest in research and practice due to their potential to address climate change while improving human health and well-being and safeguarding biodiversity. The integration of the NBS concept in urban governance, however, is still emerging and it faces regulatory, political, financial and cognitive barriers. While the literature acknowledges an incre
The purpose of this study is to look into patronage effects of extended supply outside peak hours on regional public transport services. Previous studies have shown that the service frequency is an attribute of great importance for regional passengers, but little is known about the details regarding peak and off-peak frequencies or service hours. The present study addresses this knowledge gap, dep
Urban flood damage leads to major costs for private house owners, insurance companies, and water and wastewater utilities. Analysis of flood damage claims can be used to improve the understanding of the details of flood damage characteristics and reasons for drainage system failures. However, few studies have used data of this kind to investigate urban flood characteristics. We examined 3113 damag
A large share of health-related information is today sought and communicated via the internet, including in social media. Questions have been raised about how this may affect health perceptions and behaviors, not least by enabling the communication of claims that contradict information from established medical authorities. As an example, knowledge claims about systemic side effects of the contrace
Climate change is generally expected to have a positive effect on weathering rates, due to the strong temperature dependence of the weathering process. Important feedback mechanisms such as changes in soil moisture, tree growth and organic matter decomposition can affect the response of weathering rates to climate change. In this study, the dynamic forest ecosystem model ForSAFE, with mechanistic
In times of emergent emphases on how climate change will affect welfare societies, welfare policies and individuals’ welfare and vice versa, this study investigates public support for welfare and environmental policies and concerns. Since previous research and literature have pointed towards a socioeconomic divide between the welfare agenda and the environmental agenda in terms of public support,
