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Background: Pediatric Brain Tumor (PBT) survivors suffer from cognitive sequelae, especially within the areas of cognitive tempo, attention, executive function and memory. The cognitive difficulties are often accentuated over the years, but knowledge about the long term trajectory is still scarce. Aim: The aim of this thesis was to examine cognitive sequelae after Pediatric Brain Tumor (PBT); ris
This thesis discusses aspects of feeding habits of moose (Alces alces) and their impact on forest development. The development of forage that is available to moose was studied by sampling the amount of edible biomass on pine and birch trees. A strong relationship was found between foliage (and twig) biomass and tree diameter, which corroborates the hypothesis that sapwood area limits the amount of
Complex I or NADH:quinone oxidoreductase is the largest enzyme complex, but the least understood energy coupling site in the respiratory chain of mitochondria and bacteria. No high-resolution structural information exists for this enzyme and the molecular mechanism that couples electron transfer and proton pumping is not understood. In mammals, about 50% of the mitochondrial DNA is encoding protei
Several analyses using time-resolved optical spectrocopy of pulsating white dwarfs are presented. The data have been put to a number of uses. First, line-of-sight velocities associated with the pulsations have been measured in three hydrogen-atmosphere white dwarfs (DAVs), bringing the total number of such measurements up to five. They have also been measured for the first time in a pulsating heli
This explorative study aimed to apply, develop, and evaluate assessment methods at various levels in cell replacement therapy for Parkinson’s disease (PD). Observed motor effects in five grafted patients support that timed motor tasks and clinical ratings of parkinsonism are able to monitor motor function, but their psychometric properties need further attention. Using positron emission tomograp
a1-microglobulin is a small glycoprotein present in plasma and in tissues surrounding the gastrointestinal and respiratory tracts. a1-microglobulin is a member of the lipocalin protein family and exhibits several of the typical traits of a lipocalin; it binds an unknown ligand which causes the brown color of the protein, it forms complexes with various different proteins and there have been indica
Hereditary retinal degenerations are the most frequent reason for severe visual handicap among young people in Scandinavia today. In the six papers included in this thesis the phenotypic expressions, with emphasis on the electrophysiological findings, of five different juvenile hereditary retinal degenerations are described. The diagnoses have been confirmed by genetic analysis. The retinal disord
The overall aim of the thesis was to investigate the effects of psychodynamically oriented psychotherapy and gain an increased understanding of the curative factors in psychotherapy by thorough examination of the therapeutic alliance and of client change. The core of the thesis is a naturalistic study of 22 short-term dynamic psychotherapies and a follow-up 6-12 months later. Individual outcome me
The aims were to follow stroke patients over time with respect to general pain, shoulder pain, weight loss, and health related quality of life (HRQOL), the latter also in stroke survivors' informal caregivers. Methods During a 1 year period, 416 first-ever stroke patients were included in the population based Lund Stroke Register; 327 survivors were followed up after four months and 305 one year
Objective: To explore the long-term course and to study factors of potential relevance for the treatment and rehabilitation process of patients with schizophrenia and schizophrenia-like disorders. Specific issues concerned cognitive reduction, tardive dyskinesia (TD), prolactin-induced side effects, remission and lack of insight. Method: A naturalistic multicenter study of 225 patients, diagnosed
The aim of thesis was to investigate the nurse-patient encounter in dementia care (n=9 patients), functional and cognitive ability, behaviours and mood of the patients as well as the reliability of the instruments used (n=75 nursing home patients). A further aim was to investigate the effects on the aspects mentioned above of a one-year controlled intervention (individually planned care and clinic
The overall aim of this thesis was to investigate quality of life and the meaning of living with peripheral arterial disease (PAD) before and after revascularization in a long-term and methodological perspective. The sample in the first study consisted of 142 patients with PAD who were planned for a revascularization. Quality of life (QoL) assessment with the Nottingham Health Profile (NHP) was ma
My dissertation is about bird migration and addresses questions about how raptors adapt to the fluctuating environments during the transition seasons between breeding and wintering. The migration is highly affected by local prey abundance, foraging strategies, weather conditions and landscape patterns along the migration routes as well as navigation and orientation mechanisms and cues. Interesting
Very little is known about the consequences of aging and the wellbeing of deaf sign language users. This thesis contributes to filling this knowledge gap. The overarching aim was to gain further understanding and to increase the knowledge about quality of life, in terms of subjective wellbeing and health, activity and social contacts, among older deaf sign language users. After having established
The aim of this thesis was to investigate nurses’ lived experience of daily nursing care and the impact and lived experiences of one years intervention with systematic clinical group supervision and supervised individually planned nur-sing care. This was carried out at an experimental ward (EW) (n=19) housing patients with dementia in comparison with a similar control ward (CW) (n=20) using a quas
Use of beta-blockers and inhibitors of the renin angiotensin system (RAS) is established practice in the treatment of chronic heart failure (CHF). Clinical studies also suggest beneficial long-term effects of nitrates in CHF. In the Veterans Administration Heart Failure Trial (V-HeFT) I, the combined use of a nitrate and hydralazine reduced the mortality rate. However, it is not possible to determ
Better understanding of suicidality may improve treatment and care of suicide attempters. This thesis aims at understanding suicidality by investigating suicide risk, sex differences and views of suicide attempters. Suicide risk factors (prospectively determined) differed between the sexes: Older age and high suicidal intent were female risk factors, whereas previous attempts and using a violent
Bioremediation of soils is considered a low-cost alternative to other remediation techniques. Its ability to remove a number of different pollutants has been demonstrated, relying mainly on the activities of indigenous soil bacteria. The polycyclic aromatic hydrocarbons (PAHs) are considered major environmental pollutants in soil, some of them being toxic and others carcinogenic. Since high-molecu
