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Cellular metabolite balance and mitochondrial function are under circadian control, but the pathways connecting the molecular clock to these functions are unclear. Peroxisome proliferator-activated receptor delta (PPARδ) enables preferential utilization of lipids as fuel during exercise and is a major driver of exercise endurance. We show here that the circadian repressors CRY1 and CRY2 function a

Informal leaders in the choral voice.Choir leaders’ experience of collaboration between the choristers.Most choirs and choir leaders have the aim to make the individual voices soundas unison as possible in the different choral voices, according to both timing,synchronisation and vocal blend.The aim of the present study was to investigate experienced choir leaders’experience and understanding of po

Mitochondrial metabolism is a major determinant of insulin secretion from pancreatic β-cells. Type 2 diabetes evolves when β-cells fail to release appropriate amounts of insulin in response to glucose. This results in hyperglycemia and metabolic dysregulation. Evidence has recently been mounting that mitochondrial dysfunction plays an important role in these processes. Monogenic dysfunction of mit

Stroke is a life threatening medical condition that is caused either by a blood clot or a bleeding inside the brain. It is generally agreed that immediate treatment of stroke patients is crucial for their ability to recover; however, before treatment can be initiated, the stroke patient has to be diagnosed using, for example, a computed tomography scan of the brain. This, in turn, requires that th

Our understanding of celiac disease and how it develops has evolved significantly over the last half century. Although traditionally viewed as a pediatric illness characterized by malabsorption, it is now better seen as an immune illness with systemic manifestations affecting all ages. Population studies reveal this global disease is common and, in many countries, increasing in prevalence. These s

Overall survival of patients with metastatic non-small cell lung cancer (NSCLC) has significantly improved with platinum-based salt treatments and recently with targeted therapies and immunotherapies. However, treatment failure occurs due to acquired or emerging tumor resistance. We developed a monoclonal antibody against the proform of neurotensin (LF-NTS mAb) that alters the homeostasis of tumor

It has previously been shown that infant mortality clusters in a subset of families, a phenomenon which was observed in historical populations as well as contemporary developing countries. A transmission of death clustering across generations has also been shown in Belgium, but it is unknown whether such effects are specific to the studied context or are also found in other areas. The current arti

Expression of fat mass and obesity-associated gene (FTO) and ADP-ribosylation factor-like 15 (ARL15) in human islets is inversely correlated with HbA1c. However, their impact on insulin secretion is still ambiguous. Here in, we investigated the role of FTO and ARL15 using GRINCH (Glucose-Responsive Insulin-secreting C-peptide-modified Human proinsulin) clonal rat β-cells. GRINCH cells have inserte

The role of terrestrial organic carbon for recipient aquatic ecosystems is intensively researched. A multitude of studies now show that terrestrially-derived carbon supports a significant share (allochthony) of consumer biomass in many freshwaters. However, little is known about the mechanisms by which terrestrially-derived carbon is transferred to the level of metazoan zooplankton, and whether th

An important component of the carbon cycle is the lateral flow of dissolved organic carbon (DOC) from terrestrial ecosystems to streams and rivers. The fate of this carbon depends very much on the bioavailability of DOC (BDOC), which may determine whether DOC is returned to the atmosphere as CO2 or deposited in sediments. This study focuses on the linkages between stream DOC composition, optical c