Filetype
Proton-translocating NAD(P)+ transhydrogenase (NNT) is highly expressed in cardiac tissue, where it physiologically supports mitochondrial NADPH production. However, under certain pathological conditions, NNT may shift toward consuming the mitochondrial NADPH pool. Although NNT has been implicated in redox homeostasis, its contribution to cardiac function during aging remains uncertain. In this st
This article presents a legal and empirical analysis of multiple voting share structures (MVSS) among newly listed companies in the Nordic region over a ten-year period ending in 2024. Drawing on original data and theoretical insights, we advance three key findings that question core assumptions underlying the EU’s 2024 MVSS Directive. First, we document a marked decline in the use of dual-class s
We aimed to determine if thyroid autoimmunity is associated with a child's risk for subsequent development of islet or celiac autoantibodies. Children at high genetic risk of type 1 diabetes were followed for thyroid autoimmunity (thyroid peroxidase antibodies [TPOAb] and thyroglobulin antibodies [TGAb]), islet autoimmunity (IA), and celiac disease autoimmunity [CDA] in The Environmental Determina
Saturated fatty acids impose lipotoxic stress on pancreatic β cells, leading to β cell failure and diabetes. In this study, we investigate the critical role of organellar Ca2+ disturbance on defective autophagy and β cell lipotoxicity. Palmitate, a saturated fatty acid, induced perilysosomal Ca2+ elevation, sustained mTOR complex 1 (mTORC1) activation on the lysosomal membrane, suppression of the
Extending the service life of existing buildings and their components is essential for slowing resource loops in circular construction. While overall building lifespans are relatively well understood, the actual service lives of individual components remain underexplored due to limited empirical data. This study addresses this gap by analyzing and modeling building component lifespans using real-w
Background: Co-occurring substance use disorders, and mental disorders are associated with significant suffering, high risks of violent reoffending and relapse in both substance use and psychotic episodes. Treatment for co-occurring substance use disorders in forensic mental health settings would benefit from incorporating patients’ understanding of their disorders. Method: Using an interpretative
Background: The recently launched high-throughput assays for detecting antibodies against SARS-CoV-2 has contributed to the managing strategies for the COVID-19 pandemic. This study aimed to investigate the performance of three high-throughput assays and one rapid lateral flow test relative to regulatory authorities' recommended criteria. Methods: A total of 315 samples, including 150 pre-pandemic
To meet future demands for cleaner water and comply with the revised Urban Wastewater Treatment Directive (UWWTD), many European wastewater treatment plants (WWTPs) will need quaternary treatment to reduce emissions of organic micropollutants (OMPs). Quaternary treatment based on granular activated carbon (GAC) is a promising solution, yet long-term, full-scale operational data remain scarce. This
Objectives: This study explores the dynamics of vaccine rumors during the COVID-19 pandemic, particularly those surrounding messenger RNA vaccines. By employing and developing Hallin’s communication model of credibility spheres, we analyze how controversial ideas regarding vaccine safety gained public attention and challenged established vaccine narratives. Methods: The focal point of the investig
Mobile Stroke Units (MSUs), which are specialised ambulances equipped with brain imaging devices and trained medical personnel, offer the potential for rapid on-site diagnosis and treatment, improving patient outcomes in prehospital stroke care. To fully realise their benefits, it is essential to strategically allocate. However, identifying optimal locations within a region for MSU deployment is t
The causal role of pollinators in driving the divergence of plant traits is a fundamental tenet of angiosperm evolution, providing hallmark examples of evolution in response to natural selection. However, it remains unclear how geographic variation in pollinator assemblages relates to the divergence of pollination traits in pollination-generalized plants. We characterized pollinator assemblages th
