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Decreased insulin sensitivity, also referred to as insulin resistance (IR), is a fundamental abnormality in patients with type 2 diabetes and a risk factor for cardiovascular disease. While IR predisposition is heritable, the genetic basis remains largely unknown. The GENEticS of Insulin Sensitivity consortium conducted a genome-wide association study (GWAS) for direct measures of insulin sensitiv
Acrylamide, a probable human carcinogen, has been found at mg/kg levels, in heat-treated carbohydrate-rich foods. Acrylamide is formed via the Maillard reaction as a result of the reaction between the amino acid asparagine and reducing sugars (glucose and fructose). Potatoes contain relatively high levels of both asparagine and reducing sugars and therefore potato products such as crisps, French f
Abstract What are the pedagogical impacts of internationalisation on the development of higher education in Europe? How can we proceed in this process and take a pedagogical stance on the issue? This theoretical paper is partly based on a series of empirical studies conducted by the author, investigating students’ and teachers’ experiences and understanding of an internationalised educational cont
When designing innovations for the silver age, it is not sufficient to discover old people’s needs only. In addition, one also has to discover old peoples’ new roles as consumers, citizens and innovators. Since this is a group that until recently has been given few opportunities to make their voices heard, there is a need for methods that identify their needs and demands. More importantly, we need
Stylistic Fronting (SF) is a process that fronts various types of non-subjects to the preverbal position in subjectless clauses (“that gone have”, etc.). With the exception of Icelandic and to some extent Faroese, SF has disappeared from Scandinavian varieties. It is commonly assumed that even in Icelandic it is formal and old fashioned, indicating that it might be on its way out of this language
The purpose of building classification systems is to provide the sector with agreed and standardised ter¬minology and semantics, e.g. in systems for technical specification, cost calculation, and exchange of information. There is a growing need to use classification systems in a BIM context. In inter¬¬national construction projects and international construction product trade there is a need both
One of the most important goals on solar collector development is to increase the system’s annual performance without increasing overproduction. The studied collector is formed by a compound parabolic reflector which decreases the collector optical efficiency during the summer period. Hence, it is possible to increase the collector area and thus, the annual solar fraction, without increasing the o
Whilst Building Information Modelling (BIM) promises significant improvements in construction quality and efficiency, current contractual models do not encourage its use; indeed actively inhibit the collaboration at its core. To help bring BIM into the mainstream, it is claimed we need to re-craft existing contractual relationships to facilitate collaborative decision making and to equitably alloc
According to Silvan Tomkins’ (1963, 1965) Polarity Theory, all ideologies are polarized by a fundamental conflict between Humanism, which idealizes and glorifies humanity, and Normativism, which portrays human beings as inherently worthless and able to attain value only through achievement of external norms. Research has shown that Humanism and Normativism do indeed form two coherent and negativel
The majority of patients with von Willebrand disease (VWD) have a mild bleeding tendency that primarily involves mucosal bleeding. Some patients with the disorder, however, have severe episodes of mucosal or joint bleeding that can hamper daily activities and lead to significant joint impairment. Experience in the setting of severe hemophilia has shown the feasibility and benefits of prophylactic
CONTEXT AND OBJECTIVE: During medical education and training, the values and attitudes of medical students are shaped both by knowledge and by role models. In this study, the aim was to compare the views of first- and final-year students concerning patients with different medical conditions. PARTICIPANTS AND METHOD: In the spring of 1998 all first- and final-year medical students at Göteborg and L
We have studied the degree of genetic variation at a variable Mhc class II beta gene in four populations of Atlantic salmon Salmo salar by using RFLPs. The class II beta gene encodes the part of the Mhc class II molecule that contains the antigen binding region and is therefore essential for disease resistance. There was extensive genetic variation in all four populations; the expected heterozygos
Serious psychopathology in adulthood may be associated with disturbed foetal brain development, which potentially shows lingering “fossil marks” in the cranial and facial regions. Several methods exist for assessing external craniofacial and internal brain distances but, to our knowledge, no method yet provides simultaneous measurement of cranial, facial and brain dimensions in live subjects. In t
Aims: We investigated whether polymorph isms in candidate genes involved in lipid metabolism and type 2 diabetes are related to liver I, at content. Methods: Liver fat content was measured using proton magnetic resonance spectroscopy (H-1-MRS) in 302 Finns, in whom single nucleotide polymorphisms (SNPs) in acyl-CoA synthetase long-chain family member 4 (ACSL4). acliponectin receptors 1 and 2 (ADIP
Human papillomavirus (HPV) persistence is the major cause of cervical cancer, but most HPV infections will not persist and risk factors for HPV persistence are not well known. Chlamydia (C.) trachomatis infection seems to also be associated with cervical cancer. We investigated whether C. trachomatis infection is a risk factor for HPV persistence. In a cohort of 12,527 women participating in a pop
