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Second-hand consumption of clothing can support the transition to circular economies by prolonging the lifespan of products through reuse. Historically, not-for-profit businesses have been dominant actors in second-hand markets across Western Europe and North America. However, with the growing interest in second-hand consumption, for-profit firms have increasingly entered this market over the last
As the market share of electric vehicles increases, the need for a charging infrastructure increases correspondingly. Modern Electric Road Systems is a cost effective charging infrastructure that allows electric vehicles to charge while driving and consequently allowing for smaller batteries in EVs. To assess the potential of electric road system technology, a demonstrator of conductive electric r
Apolipoprotein A-I (ApoA-I) amyloidosis is a rare protein misfolding disease where fibrils of the N-terminal domain of the protein accumulate in several organs, leading to their failure. Although ApoA-I amyloidosis is systemic, the different amyloidogenic variants show a preferential tissue accumulation that appears to correlate with the location of the mutation in the protein sequence and with th
PURPOSE: Women with current or previous drug use are at risk of poor breast and cervical cancer outcomes. While screening is known to decrease cancer mortality, screening participation is sparsely investigated among drug dependent women. The aim of this study was to explore experiences of breast and cervical cancer screening-including barriers and suggested interventions to promote increased parti
New δ34Spy (pyrite) and δ34SCAS (carbonate-associated sulfate) across the Llandovery-Wenlock boundary (∼432 Ma) provide evidence for the expansion of reduced marine environments during the Ireviken Biogeochemical Event. This event consists of a major positive carbon isotope excursion, increased biotic turnover, and other major perturbations and changes within biogeochemical cycles. This interval o
The health of coastal marine environments is severely declining with global changes. Proxies, such as those based on microeukaryote communities, can record biodiversity and ecosystem responses. However, conventional studies rely on microscopic observations of limited taxonomic range and size fraction, missing putatively ecologically informative community components. Here, we tested molecular tools
Exercise training prevents age-related decline in muscle function. Targeting epigenetic aging is a promising actionable mechanism and late-life exercise mitigates epigenetic aging in rodent muscle. Whether exercise training can decelerate, or reverse epigenetic aging in humans is unknown. Here, we performed a powerful meta-analysis of the methylome and transcriptome of an unprecedented number of h
We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacylglycerol species, and lowered sphingomyelin 42:2;2 levels are predictive of faster progression towards insulin requirement. Of ~1,300 proteins examined in two
The building sector is a major contributor to greenhouse gases, consuming significant energy and available resources. Energy renovation of buildings is an effective strategy for decarbonisation, as it lowers operational energy and avoids the embodied impact of new constructions. To be successful, the energy renovation process requires meaningful building models. However, the time and costs associa
Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with an increased risk of coronary artery disease. To date, data regarding possible associations between plasma Gal-4 and stroke are lacking. Using linear and logistic regression analyses, we tested Gal-4 association with prevalent stroke in a population-based cohort. Additionally, in
Osteocytes have recently been identified as a new regulator of bone remodeling, but the detailed mechanism of their differentiation from osteoblasts remains unclear. The purpose of this study is to identify cell cycle regulators involved in the differentiation of osteoblasts into osteocytes and determine their physiological significance. The study uses IDG-SW3 cells as a model for the differentiat
Cosmology presents students with ideas that stimulate their curiosity and brings together various concepts from STEM that call on a variety of reasoning types across multiple representational modes, involving subtleties of spacetime relations, a variety of models and evidence requiring multiple lines of high precision observations. This study investigated high school students’ levels and types of
Understanding the impact of various factors on train arrival delays is a prerequisite for effectiverailway traffic operating control and management. Existing studies analyze the train delayfactors using a single, generic regression equation, restricting their capability in accounting forheterogeneous impacts of spatiotemporal factors on arrival delays as the train travels along itsroute. The paper
