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Overall survival of patients with metastatic non-small cell lung cancer (NSCLC) has significantly improved with platinum-based salt treatments and recently with targeted therapies and immunotherapies. However, treatment failure occurs due to acquired or emerging tumor resistance. We developed a monoclonal antibody against the proform of neurotensin (LF-NTS mAb) that alters the homeostasis of tumor

Gastroparesis, characterized by delayed gastric emptying without mechanical obstruction, is a recognized complication of long-standing diabetes. Its pathophysiology involves, amongst other mechanisms, autonomic dysfunction due to vagal nerve damage, impaired smooth muscle contractility, and hormonal dysregulation of intestinal motility. During Ramadan, fasting causes significant dietary changes du

The concept of ‘sustainable welfare’ conceptualizes welfare and wellbeing within planetary limits. Yet there is a lack of knowledge about possible social and political carriers of corresponding social-ecological transformations. For the promotion of the changes of societal core institutions that climate scientists deem necessary in the nearer future knowledge of which parts of the population are m

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference a

A supercritical fluid extraction methodology was used to extract flavoring and bioactive compounds from truffles. Some parameters such as CO2 flow rate (1–3 mg/mL), extraction time (15–90 min) and different trapping food matrices (grape seed oil, gelatin, agar agar and water) were optimized using response surface methodology to enhance extraction and trapping yields. The optimal conditions (2.27 m

This article focuses on explaining management control under post-new public management (NPM). Drawing on the lessons from a case study, the article aims to advance the discussion of what post-NPM, as a new governance innovation, is and what problems practitioners encounter when they try to engage in post-NPM–oriented governance. The study reports the transformation of both management and control a

Current local or regional flood risk assessments, as required by the EU flood risk directive, rarely account for cascading effects due to interdependencies between critical infrastructures. However, it is essential to consider these effects, as they may severely impact areas outside the immediate flood risk area. The main purpose is to present and problematize a method (AB-CEM) for mapping and ana

In recent years, extreme flow events in rivers have become more frequent and caused numerous bridge failures worldwide. Such events increase headwater levels in the rivers that may cause water to flow over the bridge deck, referred to as bridge overtopping. This is one of the primary factors affecting bridge functionality, possibly leading to failure. In general, bridges are designed and construct

Imaging-defined atherosclerosis represents an intermediate phenotype of atherosclerotic cardiovascular disease (ASCVD). Genome-wide association studies (GWAS) on directly measured coronary plaques using coronary computed tomography angiography (CCTA) are scarce. In the so far largest population-based cohort with CCTA data, we performed a GWAS on coronary plaque burden as determined by the segment

Previous findings on results of treatment of aggression in violent offenders show inconsistent results, and implementations of such treatments have demonstrated varying success with sometimes marginal gains in forensic settings. New methods, incorporating virtual reality as a tool for experiential learning, have been put forward yet require deepened investigations concerning both treatment content

Introduction: Gender imbalances in academia are found globally. Even though women earn the same rate of PhD degrees, the gender imbalance becomes increasingly prominent at higher academic levels. Several reasons have been proposed for these differences, including family responsibilities, disparities in the number and size of grants awarded, invitations to present at conferences, and differences in

Human diets play a crucial role in both human health and environmental sustainability. In 2019, the EAT-Lancet Commission on healthy diets from sustainable food systems introduced the EAT-Lancet planetary health diet, a universal reference diet designed to promote human health while minimizing environmental degradation. It is a predominantly plant-based dietary pattern, rich in whole grains, veget

Understanding the microclimate in a given site influences the preconditions of sustainable development in many ways. Cold and strong winds in the winter will, for example, intensify the energy use in buildings depending on the air tightness of the building enclosure (Bagge et al., 2011), and in areas close to the seafront strong salty winds may also increase the wear and tear on building materials

This data package contains high accuracy CO2 dry air mole fractions from 58 ICOS and non-ICOS European observatories at in total 132 observation levels, collected by the ICOS Atmosphere Thematic Centre (ATC) and provided by the station contributors. The package is part of the Globalviewplus v8.0 data product, released in 2022 and is intended for use in carbon cycle inverse modeling, model evaluati