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Neisseria gonorrhoeae is the etiological agent of gonorrhea, the second most common bacterial sexually transmitted infection worldwide. Reproductive sequelae of gonorrhea include infertility, ectopic pregnancy and chronic pelvic pain. Most antibiotics currently in clinical use have been rendered ineffective due to the rapid spread of antimicrobial resistance among gonococci. The developmental pipe
Purpose: This paper aims to study the effects of different weather conditions on typical concrete work tasks’ productivity. Weather is one important factor that has a negative impact on construction productivity. Knowledge about how weather affects construction works is therefore important for the construction industry, e.g. during planning and execution of construction projects. Design/methodolog
This paper describes the functional development of the ClimApp tool (available for free on iOS and Android devices), which combines current and 24 h weather forecasting with individual information to offer personalised guidance related to thermal exposure. Heat and cold stress assessments are based on ISO standards and thermal models where environmental settings and personal factors are integrated
Lipid uptake can be facilitated via caveolae, specific plasma membrane invaginations abundantly expressed in adipocytes. The dynamin-related protein EH domain-containing 2 (EHD2) stabilizes caveolae at the cell surface. Here, we have examined the importance of EHD2 for lipid handling using primary adipocytes isolated from EHD2 knockout (Ehd2−/−) C57BL6/N mice. Following high-fat diet (HFD) feeding
AimIntraoperative rectal washout is performed to eliminate exfoliated intraluminal cancer cells and thereby decrease the risk of local recurrence. Rectal washout in abdominoperineal resection has not been studied. The aim of this study was to assess the oncological outcome after rectal washout in abdominoperineal resection for rectal cancer and to find evidence as to whether rectal washout should
Type 1 diabetes is a chronic autoimmune disease requiring insulin treatment for survival. Prolonged duration of type 1 diabetes is associated with increased risk of microvascular complications. Although chronic hyperglycemia and diabetes duration have been considered as the major risk factors for vascular complications, this is not universally seen among all patients. Persons with long-term type 1
Background: The COVID-19 pandemic presents great challenges on transmission prevention, and rapid diagnosis is essential to reduce the disease spread. Various diagnostic methods are available to identify an ongoing infection by nasopharyngeal (NPH) swab sampling. However, the procedure requires handling by health care professionals, and therefore limits the application in household and community s
Background & AimsYAP (Yap1) and TAZ (Wwtr1) are transcriptional co-activators and downstream effectors of the Hippo pathway, which play crucial roles in organ size control and cancer pathogenesis. Genetic deletion of YAP/TAZ has shown their critical importance for embryonic development of the heart, vasculature, and gastrointestinal mesenchyme. The aim of this study was to determine the functi
The overall aim of this PhD thesis was to investigate sedimentary micro-environments and ecosystemfunctioning of two coastal areas. We combined different high spatial resolution methods and multivariate analyses atdifferent spatio-temporal scales to reveal interactions between benthic faunal and geochemical compartments. Firstly,we investigated two stations with contrasted oxygen, nitrate and mang
The Silurian was a dynamic time characterized by significant climatic and sea level changes, biotic crises, and carbon cycle volatility. The largest magnitude perturbation to the Silurian global carbon cycle was the mid-Ludfordian carbon isotope excursion, termed the Lau CIE, which was coincident with the Lau/Kozlowskii extinction (LKE). Much of the published research on the late Silurian has desc
Cartilage oligomeric matrix protein (COMP) is a regulator of the extracellular matrix and is expressed primarily in the cartilage. Recently, COMP expression was also documented in breast cancer patients both in sera and tumor biopsies, in both of which it could serve as an independent prognostic marker. This study aimed to assess COMP as a potential biomarker in the group of metastatic breast canc
Social networks are usually considered as positive sources of social support, a role which has been extensively studied in the context of domestic violence. To victims of abuse, social networks often provide initial emotional and practical help as well useful information ahead of formal institutions. Recently, however, attention has been paid to the negative responses of social networks. In this a
Light pollution, light in the wrong place at the wrong time, is an emerging environmental issue with wide-ranging consequences. It interferes with the fundamental 24 h light–dark cycle, and has biological effects at all levels, from molecules to ecosystems, including human health and welfare. Here, exemplified by flood-lit churches, artificial lights compromise the survival of resident bats, as da
