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The building sector is a major contributor to greenhouse gases, consuming significant energy and available resources. Energy renovation of buildings is an effective strategy for decarbonisation, as it lowers operational energy and avoids the embodied impact of new constructions. To be successful, the energy renovation process requires meaningful building models. However, the time and costs associa

Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with an increased risk of coronary artery disease. To date, data regarding possible associations between plasma Gal-4 and stroke are lacking. Using linear and logistic regression analyses, we tested Gal-4 association with prevalent stroke in a population-based cohort. Additionally, in

Osteocytes have recently been identified as a new regulator of bone remodeling, but the detailed mechanism of their differentiation from osteoblasts remains unclear. The purpose of this study is to identify cell cycle regulators involved in the differentiation of osteoblasts into osteocytes and determine their physiological significance. The study uses IDG-SW3 cells as a model for the differentiat

Cosmology presents students with ideas that stimulate their curiosity and brings together various concepts from STEM that call on a variety of reasoning types across multiple representational modes, involving subtleties of spacetime relations, a variety of models and evidence requiring multiple lines of high precision observations. This study investigated high school students’ levels and types of

Understanding the impact of various factors on train arrival delays is a prerequisite for effectiverailway traffic operating control and management. Existing studies analyze the train delayfactors using a single, generic regression equation, restricting their capability in accounting forheterogeneous impacts of spatiotemporal factors on arrival delays as the train travels along itsroute. The paper

Understanding the impact of various factors on train arrival delays is a prerequisite for effective railway traffic operating control andmanagement. Existing studies model the train delay prediction problems using a single, generic equation, restricting their capabilityin accounting for heterogeneous impacts of spatiotemporal factors on arrival delays as the train travels along its route. The pape

The extent to which increased liver fat content influences differences in circulating metabolites and/or lipids between low-birth-weight (LBW) individuals, at increased risk of type 2 diabetes (T2D), and normal-birth-weight (NBW) controls is unknown. The objective of the study was to perform untargeted serum metabolomics and lipidomics analyses in 26 healthy, non-obese early-middle-aged LBW men, i

Background: Child and Adolescent Mental Health Services (CAMHS) currently seeks to implement service models that are better suited for young service users with complex mental health needs. This study explored what adolescents view as the key components of a well-functioning contact with CAMHS. Methods: This study was conducted as part of the ongoing implementation of Flexible Assertive Community T

Currant, and in particular blackcurrant, Ribes nigrum, is widely grown in Europe. It is the host of a number of pest insects, but their occurrence and the damage they cause vary geographically. In northern Europe, three lepidopteran species, the currant shoot borer (Lampronia capitella), the currant clearwing (Synanthedon tipuliformis), and the currant bud moth (Euhyponomeutoides albithoracellus),

Insulin secretion from vesicles within pancreatic beta cells occurs through the rapid (≤10 ms) process of exocytosis. A crucial final step in this process is the formation of a fusion pore, which connects the insulin vesicle interior to the extracellular space and insulin secretion rate. We employed real-time single-cell amperometry (SCA) with microsensors to quantitatively and dynamically monitor

The construction sector contributes around 37 % of global CO2 emissions, highlighting the need for de-carbonization. Part of the emissions originate in the use of diesel-driven heavy equipment. Considering the fast pace of transitioning from fossil fuels to electricity in other vehicle sectors, this may be a possible path for heavy equipment, considering the introduction of electric heavy equipmen

Structured abstractPurposeThe purpose is to examine how academic researchers perceive the communication dynamics in virtual and hybrid conferences to gain access to communities of knowledge. The paper contributes to the research field of strategic communication.MethodologyUsing a qualitative, interpretive approach, purposive sampling was utilised to recruit a diverse group of researchers from Swed

Immune checkpoint inhibitors (ICIs), targeting checkpoint receptors such as programmed cell death protein 1 (PD-1), are associated with increased risk of cardiovascular events, but the underlying mechanisms remain poorly understood. Here we show that PD-1 + T cells from murine atherosclerotic aortas mainly display a progenitor exhausted phenotype (PD-1 intSlamf6 +Tim3 -), produce IFNγ in vivo, exh

Recessive diseases arise when both copies of a gene are impacted by a damaging genetic variant. When a patient carries two potentially causal variants in a gene, accurate diagnosis requires determining that these variants occur on different copies of the chromosome (that is, are in trans) rather than on the same copy (that is, in cis). However, current approaches for determining phase, beyond pare