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Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Braz
Med hjälp av ett automatiserat mätsystem för partikelhalter i vatten har vattenkvaliteten vid Borensbergs vattenverk i Motala kommun undersökts under ett års tid med avseende på mikroskopiska partiklar i dricksvatten och råvatten. Antalet mikroskopiska partiklar registrerades som absoluta värden i realtid. I denna artikel diskuteras hur larmgränser skall definieras i praktiken för partikelhalter o
Research on early postwar documentation efforts related to the Second World War and the Holocaust conducted by survivors of Nazi persecution has expanded over the past two decades. Yet, research on how knowledge circulatedtween these efforts – especially across various “borders” – is still nascent. This chapter seeks to gain a better understanding of the role of women’s informalworks during the ea
We assessed if fasting plasma insulin levels in pregnant women with obesity are associated with newborns’ abdominal fat deposition (dual-energy X-ray absorptiometry) and with cord blood DNA methylation (450k array) in 232 mother–child pairs from the Treatment of Obese Pregnant women (TOP) study. Fasting maternal insulin at 18-20gw was associated with abdominal/total fat mass ratio in newborns inde
Thirty years on, gender mainstreaming is still a dominant strategy for working with gender equality, even though its effectiveness is debated. This is also the case in Sweden. This study focuses on how organisations in public administration, particularly municipalities and regions, are introduced to and approach gender mainstreaming. It aims to contribute with in-depth knowledge of how organisatio
Micropollutants in wastewater can persist through conventional treatment, threatening ecosystems and human health through toxicity, bioaccumulation, and disruption of biological processes. Limited monitoring, due to cost and methodological challenges, allows these compounds to go undetected, potentially leading to long-term, irreversible impacts. To address this, modern wastewater treatment plants
This study examines the relationship between income-related health inequality (IRHI) and macroeconomic conditions. We complement an income group-based analysis of the impact of macroeconomic conditions on mortality by incorporating an analysis of the concentration index as a comprehensive measure of overall IRHI. Using a recentered influence function regression approach, we estimate the impact of
This work presents the development and evaluation of a Direct Membrane Filtration (DMF) concept for municipal wastewater treatment, integrating microsieving, microfiltration/ultrafiltration (MF/UF), and downstream polishing with activated carbon. DMF enables the efficient separation of particulate organic matter directly from raw wastewater, producing a retentate suitable for enhanced biogas produ
Hybrid photon counting detectors have significantly advanced synchrotron research. In particular, the introduction of large cadmium telluride-based detectors in 2015 enabled a whole new range of high-energy X-ray measurements. This article describes the specifications of the new PILATUS4 cadmium telluride detector and presents results from prototype testing for high-energy powder X-ray diffraction
Exposure to maternal type 1 diabetes (T1D) during pregnancy provides relative protection against T1D in the offspring. This protective effect may be driven by epigenetic mechanisms. Here we conducted an epigenome-wide blood analysis on 790 young children with and 962 children without a T1D-affected mother, and identified differential DNA methylation (q < 0.05) at multiple loci and regions. These i
Membrane technology has revolutionized protein recovery in the food industry, beginning with whey protein extraction via ultrafiltration. This success led to its application in concentrating animal proteins like blood plasma, fish proteins, and albumen. As the protein shift towards plant-based sources grows, membrane processes now enable the industrial recovery of wheat, sunflower, and rapeseed pr
Background: People with intellectual disabilities experience significant health inequities. Digital interventions for health promotion are rarely designed from their specific needs. This study aimed to uncover core qualities of digital interventions for health promotion by exploring factors influencing health behaviours amongst people with intellectual disabilities. Methods: This study was conduct
The gut microbiota is associated with human health and disease. Here we conducted a genome-wide association study of host genetic factors influencing gut microbiota composition in 12,652 individuals from the Trøndelag Health Study (HUNT), with replication in Nordic cohorts (n = 16,017–21,976). We identified 12 reproducible SNP–species associations across six genomic loci, including known (LCT, ABO
Somatostatin, produced by pancreatic islet δ cells, is a key intra-islet paracrine factor that regulates the secretion of the glucoregulatory hormones insulin and glucagon from β cells and α cells, respectively. Here, we show that glutamate and glucagon released by α cells cooperatively activate neighbouring δ cells through AMPA and glucagon receptors, thereby enabling spatiotemporal feedback cont
