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Abstract:Background Type 1 diabetes (T1D) is one of the most common childhood autoimmune diseases, with rising incidence worldwide with a male predominance. The etiology behind the disease is mostly unknown and it is essential to understand the factors that impact its development to prevent the disease and personalize the treatment. This thesis aims to examine sex-specific differences in T1D, expl

Background: Pragmatics is the functional use of language in ever-changing social contexts. One early pragmatic ability is decontextualized language;to talk about events and things beyond here and now. Pragmatic difficulties are practically universal in ASD, but we don’t know about impairmentsin early pragmatic development. Further, the roles of early socio-communication and linguistic abilities in

IMPORTANCE Although spouses strongly resemble one another in their risk for alcohol use disorder (AUD), the causes of this association remain unclear. OBJECTIVES To examine longitudinally, in first marriages, the association of a first registration for AUD in one spouse with risk of registration in his or her partner and to explore changes in the risk for AUD registration in individuals with multi

The alarming rates of extinction and degrading ecosystems call for new means of understanding and accounting for how people depend on nature. Ecosystem services (ES) is a contested but widely applied concept aiming to connect ecosystem functions to human wellbeing and to assess and account for how nature matters in decision-making. More diverse frameworks and ideas of value intended for assessment

The detrimental effect of a lengthy summer vacation on important scholastic abilities such as reading, writing and mathematical skills is relatively well documented, but how language skills are affected by summer vacation is less investigated. The purpose of our study is to investigate how lexical organization and retrieval assessed by a semantic verbal fluency (SVF) task and oral narrative abilit

IntroductionConsidering that on average in developed countries we spend about 65% of our time in private homes, understanding the exposures in homes is of outmost importance. Aerosol concentrations indoors come from indoor sources, infiltrate from outdoors and can be formed from precursors both of indoor and outdoor origin. Several characteristics and processes influence the properties of aerosols

Worldwide, information and communication technologies (ICT), particularly in the sense of digital literacy, are increasingly considered as both inevitable and indispensable parts of the school curriculum. Also, international student assessment studies like PISA have on several occasions assessed computer and information literacy. Additionally, classrooms, teaching and learning, as well as school a

The general aim of the research programme SPEAK (Sustainable Planning andEnvironmental Assessment Knowledge, www.speakproject.se) was to generateknowledge on, and to strengthen the role of strategic environmental assessment(SEA) in planning as a measure to attain the environmental quality objectives andto promote sustainable development. The SPEAK programme had atransdisciplinary point of departur

IntroductionThis contribution presents recent research results on segmental andsuprasegmental cues to word-internal and sentence-level structure. InSwedish, prosody is tightly connected to morphological and syntacticstructure. For example, every word stem is pronounced with either a low or ahigh tone. The stem tone depends on what follows the stem. Thus, if asingular suffix is connected to the wor

G protein-coupled receptor 30 (GPR30) is a G protein-coupled receptor (GPCR) that is attracting considerable attention in breast cancer and cardiometabolic regulation. Following reports that GPR30 is required for some rapid estrogen responses, e.g. increased cAMP production and ERK1/2 activity, in estrogen receptor (ER)-negative cells, GPR30 was renamed G protein-coupled estrogen receptor 1 (GPER1

Land use change from agricultural intensification has been highlighted as one of the major drivers of global declines in insects, reducing species diversity and abundance and shifting community composition towards generalist species. However, it remains a challenge to determine how land use change impacts the genetic diversity of species and populations even if this diversity is vital to their lon

Importance: Preterm birth has been associated with increased risk of heart failure (HF) early in life, but its association with new-onset HF in adulthood appears to be unknown. Objective: To determine whether preterm birth is associated with increased risk of HF from childhood into mid-adulthood in a large population-based cohort. Design, Setting, and Participants: This national cohort study was c

Objectives: The main goal of the COVIDENZA trial is to evaluate if inhibition of testosterone signalling by enzalutamide can improve the outcome of patients hospitalised for COVID-19. The hypothesis is based on the observation that the majority of patients in need of intensive care are male, and the connection between androgen receptor signalling and expression of TMPRSS2, an enzyme important for

UppdragArbetet med kunskapssammanställningen definierades av Myndigheten förarbetsmiljökunskap till att omfatta den psykosociala arbetsmiljöns inverkanpå den seniora arbetskraften1 i en svensk kontext, det vill säga effekten påindividen utifrån den mentala arbetsmiljö och den arbetssociala miljö somhen befinner sig i. Dock samvarierar olika faktorer i individers arbetssitua-tion. För att fånga in

Background: During the 21st century, diabetes mellitus (DM) and peripheral artery disease (PAD) have become global problems. It is estimated that 19-34% of individuals with DM will develop a foot ulcer during their lifetime, and many will be amputated.Aim:-To study dietary and lifestyle factors associated with prevention of PAD among individuals with DM. -To evaluate outcomes after vascular and en