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The role of mitochondria in apoptosis is well known; however, the mechanisms linking mitochondria to the proapoptotic effects of proinflammatory cytokines, hyperglycemia, and glucolipotoxicity are not completely understood. Complex Ca2+ signaling has emerged as a critical contributor to these proapoptotic effects and has gained significant attention in regulating the signaling processes of mitocho

Fine-tuning of insulin release from pancreatic β-cells is essential to maintain blood glucose homeostasis. Here, we report that insulin secretion is regulated by a circular RNA containing the lariat sequence of the second intron of the insulin gene. Silencing of this intronic circular RNA in pancreatic islets leads to a decrease in the expression of key components of the secretory machinery of β-c

The transport of neutrons in long beamlines at spallation neutron sources presents a unique challenge for Monte-Carlo transport calculations. This is due to the need to accurately model the deep-penetration of high-energy neutrons through meters of thick dense shields close to the source and at the same time to model the transport of low- energy neutrons across distances up to around 150 m in leng

Neuropeptide Y (NPY) has been implicated in the control of food intake and energy balance based on many observations in animals. We have studied single nucleotide polymorphisms (SNPs) within the regulatory and coding sequences of the human NPY gene. One variant (1128 T>C), which causes an amino acid change from leucine to proline at codon 7 in the signal peptide of NPY, was associated with increas

The purpose of this article is to address issues of artistic knowledge and artistic learning by way of studying, through a concrete exemplification, the meanings and implications of linguistic metaphor in artistic and educational conceptualizations of spoken theatre. Professional artists and pedagogues in this field habitually use the concept of musicality to point to key qualities in actors’ arti

The combination of coagulation/flocculation and discfiltration with ozonation to reduce nutrients and organic micro-pollutants in secondary effluent was studied in pilot scale at Lundåkraverket wastewater treatment plant in Landskrona, Sweden. With a chemical dose of 4 gAl3þ/m3 and 1.5 g/m3 cationic polymer as active material effluent water quality with regards to total phosphorous (Tot-P), suspen

The focus of this study is on product innovations done by firms (establishments) and the collaborations they enter into with other firms and organizations in carrying out this activity. The theoretical framework combines innovation theories with the literature on regional innovation systems, industrial districts/clusters and knowledge-based economies. Empirically we have investigated the frequency

Purpose: The purpose of this paper is to contribute to the ongoing discussion on how the field of facility management is changing and the role a regional innovation system (RIS) can take place to support this change, with a specific focus on the role of gender and innovation. Design/methodology/approach: The study builds partly on interactive research, and as a complement, qualitative semi-structu

The presence of serotonin (5-hydroxytryptamine [5-HT]) in pancreatic endocrine cells is well established. Nevertheless, recent advances are only now unraveling the signaling network involving 5-HT that partly regulates the release of hormones emanating from the islets of Langerhans. It is widely accepted that failure of the pancreatic β-cell to release sufficient amounts of insulin is the main cul

Landscape is an important public interest with social, cultural, ecological, and environmental dimensions. It is central to the formation of local cultures and contributes to human well-being. Some areas are protected by supranational agreements that have significant international value. The European Landscape Convention (ELC) calls for integrating landscape considerations into other policy areas

The number of medically fragile children cared for at home is increasing; however, there are few studies about the professional support these families receive in their homes. The aim of the study was to understand the meanings that parents had about the support they received from health care professionals who offered care for their ventilator-assisted child in the family home. A phenomenological-h

BACKGROUND: The concept of organ transplantation as treatment for complex genetic conditions, including Wolcott-Rallison syndrome (WRS), continues to show promise. Liver transplantation is essential for survival of patients with WRS, and pancreas transplantation cures their type I diabetes mellitus. METHODS: The recipient, a 3-year-old girl weighing 14 kg at the time of transplantation, suffered f

Public sector mergers have the potential of being viable alternative to other public sector reforms in the striving toward making public service provision more equipped to confront some of the challenges faced today. Mergers however often fail to deliver promised results. Previous research point to the importance of post-merger integrating processes for realizing the synergies expected from merger

Most adpositions in North Sámi are postpositions – they follow their complements in the surface order. Nouns, on the other hand, invariably precede their complements. Strikingly, when the nominal complement of a postposition has its own complement, the complement of the noun follows after the postposition, so that the nominal phrase ends up being discontinuous,split by the postposition. This is an

Advances in sequencing technologies led to rapid increase in the number and diversity of biological sequences, which facilitated development in the sequence research. In this paper, we present a new method for analyzing protein sequence similarity. We calculated the spectral radii of 20 amino acids (AAs) and put forward a novel 2-D graphical representation of protein sequences. To characterize pro

Type 2 diabetes (T2D) is widespread, affecting the health of hundreds of millions worldwide. The disease results from the complex interplay of lifestyle factors acting on a backdrop of inherited DNA risk variants. Detecting and understanding biomarkers, whether genotypes or other downstream biological features that dictate a person's phenotypic response to different lifestyle exposures, may have t