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Glucagon secretion by pancreatic α-cells is triggered by hypoglycemia and suppressed by high glucose levels; impaired suppression of glucagon secretion is a hallmark of both type 1 and type 2 diabetes. Here, we show that α-cell glucokinase (Gck) plays a role in the control of glucagon secretion. Using mice with α-cell-specific inactivation of Gck (αGckKO mice), we find that glucokinase is required
Among the issues relating to the needs of citizens with reduced functional capacity, accessibility problems throughout society are gaining interest. The focus of this paper is on methodology for assessment of urban public bus transport accessibility. The aims are to describe the development of a pilot version of a new instrument, the Travel Chain Enabler, and to identify problems to target for fur
This study addresses the enduring problem of the mismatch between firms' offerings and consumers' desires. It combines the general framework of modernity theory with the concept of regimes and uses the food area as the empirical context. Our cultural analytical study of consumers' and firms' articulation of values of food and meal demonstrates that firms are largely entrenched in the modern era, c
Background: Cognitive functioning may have implications for engagement in daily occupationsamong people with schizophrenia.Objectives: This cross-sectional study explores relationships between time use assessed occupationalengagement and cognitive functioning among persons with schizophrenia.Methods: Thirty-nine participants from four mental health care services in Sweden participated.The Profile
Genome-wide association studies (GWAS) have generated considerable interest in glucokinase regulatory protein (GKRP; gene name GCKR) which is an inhibitor of hepatic glucokinase (GCK), an enzyme that plays a critical role in glucose update and disposal in liver. From the initial discovery of GCKR variants associated with triglyceride and glucose levels through the identification of pleiotropic ass
Concerns have been raised about the quality of reporting in nutritional epidemiology. Research reporting guidelines such as the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement can improve quality of reporting in observational studies. Herein, we propose recommendations for reporting nutritional epidemiology and dietary assessment research by extending the ST
Are foreign ministers punished for their performance in office, or when the country loses a war? The literature has increasingly recognized the importance of individual leaders when explaining foreign policy outcomes. Several scholars have focused on the survival of leaders as an important predictor of war onset, which has created an interest in predicting the survival of heads of governments. We
This paper presents early findings of a study on how users appropriate a computerised mobile system designed to administer service orders. The theoretical lens used was Adaptive Structuration Theory (AST) and focused on Structural Features, Spirit and Appropriation of Structure. In order to accomplish the purpose, two aspects were to be considered: the system’s structure and the user’s appropriati
In most of the world, borehole heat exchangers used with closed-loop ground source heat pump systems are backfilled with a low permeability grout to prevent water contamination. However, in Scandinavian countries, a different approach is taken – the borehole is sealed at the top and cased down to solid bedrock. The borehole then naturally fills with groundwater in the annular space between the U-t
This research addresses local governance for building energy efficiency. In order to turn an increasingly proactive environmental policy agenda at subnational levels into practice, local governments experiment with new forms of governance. One important policy area in this regard is building energy use, often addressed through urban development projects. Such initiatives provide important insight
