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The purpose of this chapter is to discuss the legal issues relating to cruise ship passenger contracts, their nature and salient features, parties to the contract and their rights and obligations. Claims arising out of passenger carriage subject to applicable law and contracts containing standard terms and conditions are addressed. It is rare for passengers to examine the terms and conditions of t

The concert was part of ZIP VENICE GUITAR FESTIVAL 2024, a format created within the Guitar School of the Benedetto Marcello Conservatory of Music in Venice.Programme Marsilio Ficino (1433-1499) Music is nothing but a decoration of silence Johann Ssebastian Bach (1685-1750) Sarabande and 2 Gavottes from cello suite No 6,BWV 1012 Heitor Villa-Lobos (1887-1959) Mazurka-chôroBach Sarabande from lute

ABSTRACT Intact insulin signaling and glucose transport in adipocytes are crucial to maintaining whole-body energy metabolism. Focal adhesion kinase stands as a central intracellular protein facilitating signaling between the extracellular matrix and the cytoplasm, thereby regulating cellular metabolism. Here, we have investigated the role of focal adhesion kinase in adipocyte glucose transport us

Background Von Willebrand factor (VWF) and coagulation factor VIII (FVIII) plasma levels are associated with increased risk for venous thromboembolism (VTE). Objectives This study aimed to determine the thrombotic risk of rare and common variants of 27 genes linked to VWF or FVIII plasma levels in genome-wide association studies. Methods Exon sequences of 27 genes linked to plasma levels of VWF or

This chapter discusses the role of placed-based relational entanglements in disasters and argues that relations play an important part in shaping how disasters unfold. Exploring the case of mining induced displacement in Sweden’s Malmfälten region – where two cities, Kiruna and Malmberget, and several villages are being moved or razed to make way for expanding mines – the chapter demonstrates how

Public libraries are increasingly acknowledged as important social infrastructures that can stimulate a sense of community, social cohesion and mental wellbeing. This paper investigates how (inter)national, provincial and local policies conceptualise and fund libraries as social infrastructures in three European cities. Drawing on 32 semi-structured interviews with library management and associatiPublic libraries are increasingly acknowledged as important social infrastructures that can stimulate a sense of community, social cohesion and mental wellbeing. This paper investigates how (inter)national, provincial and local policies conceptualise and fund libraries as social infrastructures in three European cities. Drawing on 32 semi-structured interviews with library management and associati

Social workers strive to provide the best support to each client, making it crucial to consider not just group-level effects of interventions but also individual outcomes. While empirical evidence often stems from group-based analyses, these offer limited insights into individual change, which is key for tailoring interventions. The aim of this study is to highlight the importance of individual-le

The CorA/Mrs2 family of pentameric proteins are cardinal for the influx of Mg2+ across cellular membranes, importing the cation to mitochondria in eukaryotes. Yet, the conducting and regulation mechanisms of permeation remain elusive, particularly for the eukaryotic Mrs2 members. Here, we report closed and open Mrs2 cryo-electron microscopy structures, accompanied by functional characterization. M

Diabetic kidney disease (DKD) is the leading cause of end stage kidney failure worldwide, of which cellular insulin resistance is a major driver. Here, we study key human kidney cell types implicated in DKD (podocytes, glomerular endothelial, mesangial and proximal tubular cells) in insulin sensitive and resistant conditions, and perform simultaneous transcriptomics and proteomics for integrated a

Antimicrobial peptides (AMPs), particularly host defense peptides (HDPs), have gained recognition for their role in host defense mechanisms, but they have also shown potential as a promising anticancer, antiviral, antiparasitic, antifungal and immunomodulatory agent. Research studies in recent years have shown HDPs play a crucial role in endothelial cell function and biology. The function of endot

Increasing the share of travelers using public transport is one way to address environmental problems such as carbon dioxide emissions. Senior citizens represent an increasingly important group in this transition, as they are increasingly mobile and make up a large share of the population. In this paper, we investigate senior citizen's mobility decision-making, focusing on public transport. Throug

first_pageDownload PDFsettingsOrder Article ReprintsOpen AccessArticleDiagnostic Performance of Clinical and Routine Laboratory Data in Acute Mesenteric Arterial Occlusion—An International Multicenter Studyby Yasmin Soltanzadeh-Naderi 1ORCID,Annika Reintam Blaser 2,3ORCID,Martin Björck 2,4,Alexandre Nuzzo 5ORCID,Joel Starkopf 2,6,Alastair Forbes 2,Marko Murruste 2,6ORCID,Kadri Tamme 2,6ORCID,Peep

Type 2 diabetes (T2D) has a heterogeneous etiology influencing its progression, treatment, and complications. A data driven cluster analysis in European individuals with T2D previously identified four subtypes: severe insulin deficient (SIDD), severe insulin resistant (SIRD), mild obesity-related (MOD), and mild age-related (MARD) diabetes. Here, the clustering approach was applied to individuals

This chapter addresses opportunities and challenges in urban planning by implementing the concept of ecosystem services in an urban tourism and destination development context. In analysing ecosystem services in urban tourism, we contribute to an emerging literature focusing on urban ecosystem services. An important research gap is also addressed; despite the importance of tourism for cities, ther

Analogs of the incretin hormones Gip and Glp-1 are used to treat type 2 diabetes and obesity. Findings in experimental models suggest that manipulating several hormones simultaneously may be more effective. To identify small molecules that increase the number of incretin-expressing cells, we established a high-throughput in vivo chemical screen by using the gip promoter to drive the expression of

Aerosols and their interaction with clouds constitute the largest uncertainty in estimating the radiative forcing affecting the climate system. Secondary aerosol formation is responsible for a large fraction of the cloud condensation nuclei in the global atmosphere. Wetlands are important to the budgets of methane and carbon dioxide, but the potential role of wetlands in aerosol formation has not

In eukaryotes, iron-sulfur clusters are essential cofactors for numerous physiological processes, but these clusters are primarily biosynthesized in mitochondria. Previous studies suggest mitochondrial ABCB7-type exporters are involved in maturation of cytosolic iron-sulfur proteins. However, the molecular mechanism for how the ABCB7-type exporters participate in this process remains elusive. Here