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Popular Abstract in English In an organism the DNA contains the entire biological information that is needed to be able to exist and function. Those segments, also known as DNA sequences are a genetic code, which is further packaged into units called genes. The entity of all genes is called genome. Today we know, that only a small proportion of genes encode for proteins, which are responsible for More than 90% of DNA does not code for proteins and for a long time these sequences were referred to as “junk DNA” due to their unknown purpose. With the advent of new technologies it is now known, that the non-coding part of the genome is of great importance for regulating gene expression and is therefore indispensable. Transposable elements comprise about 50% of the genome and co-exist as symbio

A quarter of a century has elapsed since the catastrophe at the nuclear power plant in Chernobyl. The radioactive fallout affected all the European countries and most severely the three countries of Belarus, Russia and Ukraine. In the aftermath of this devastating event, the scientific knowledge on the various radiological impacts of such a large scale accident and means to remediate these impacts

Introduction: Several life-threatening intra-abdominal conditions may be treated with open abdomen (OA) therapy. Potential complications to OA treatment include damage to the exposed bowel resulting in enteric fistulas, and inability to close the abdomen afterwards resulting in large ventral hernias. Vacuum-assisted wound closure and mesh-mediated fascial traction (VAWCM) is a novel technique for

Rapid, accurate diagnosis and management of TB in HIV-positive individuals is critical for the success of antiretroviral treatment programmes in primary health care in Sub-Saharan Africa. These studies aim to develop and evaluate methods for TB case finding in adults receiving care at Ethiopian health centres. The prevalence of active TB in a prospective cohort of 812 HIV-positive adults was deter

This thesis is about two problems in the intersection of communication and control theory. Their common feature is that they involve communication over an additive white noise channel with a signal-to-noise ratio (SNR) constraint. The first problem concerns the transmission of a real-valued signal from a partially observed Markov source. The distortion criterion is the mean squared error and the

Antibodies are important protein structures in the immunological defence. Occasionally the regulation of the production of these antibodies fails and antibodies directed against self structures are produced in large scale. Antibody production can also complicate or make transfusions and transplantations impossible. Purified protein A from Staphylococcus aureus immobilised to beaded agarose can ads

Microvascular surgery enables free tissue flaps to cover tissue defects, e.g. after trauma and malignancies. Although major improvements in techniques have been made, problems with poor tissue circulation and thrombus formation still exist. The aim of this thesis was to investigate the effects of hemodilution on tissue blood flow and thrombus formation in an animal model. In isovolemic hemodilutio

The best mode of delivery for fetuses with intrauterine growth restriction (IUGR) and umbilical artery (UA) blood flow changes is not well elucidated. Uterine artery, fetal UA, middle cerebral artery (MCA), and venous blood flow changes during uterine contractions during an oxytocin challenge test (OCT) have not been observed systemically. AIMS: To evaluate outcome in IUGR with UA blood flow chang

Autoantibodies against glutamic acid decarboxylase (GADA), protein tyrosine-phosphatase-like protein (IAÐ2A), and/or pancreatic islet cells (ICA) are autoimmune markers usually present at diagnosis of Type 1 diabetes. Type 1 diabetes is therefore in general believed to be caused by an immune-mediated beta cell destruction. In children this destruction is fast, whereas in adult patients Type 1 diab

The thesis investigated clinical, neuroimaging and prognostic features in lacunar infarction. The studies were based on a series of 100 consequtive patients with a first-ever stroke and a lacunar syndrome investigated with CT, Gd-DTPA enhanced MRI, and with respect to large vessel disease and cardioembolic sources. the patients were followed for a mean of 4 years. MRI was repeated one year after s

Human milk contains a vast array of bioactive molecules, with nutritional and protective functions. This thesis describes the effects of a human milk protein complex, MAL, on tumour cells and bacteria. During our studies on the anti-adhesive properties of human milk we observed that a milk fraction killed tumour cells. The morphology of the cells indicated apoptotic cell death and this was verifie

Hunger and satiety are the results of complex neural events that involve several neurotransmitters and peptides. Enterostatin is an appetite-regulating peptide released in the intestine in response to fat ingestion. Enterostatin specifically decreases fat intake, but has also metabolic effects like inhibition of insulin secretion. Enterostatin has both central and gastrointestinal site of action,

The autoimmune disease Systemic Lupus Erythematosus is associated with hereditary deficieny of early components from the classical pathway of complement activation, but not with deficiency of complement component C3 or of the alternative pathway components. The classical pathway is involved in elimination of pathological immune complexes from the circulation by transport via complement receptor ty

The rapid developments within the life science and biotechnology areas put up ever-new demands on more sophisticated techniques and methods for chemical and biological analysis to reach deeper insight into the events at molecular level. Miniaturisation of assays and systems on microchips is one way to increase throughput and advance through parallel analysis lines, multiplexing and integration. Th