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The DIRECT (Diabetes Research on Patient Stratification) Study is part of a European Union Framework 7 Innovative Medicines Initiative project, a joint undertaking between four industry and 21 academic partners throughout Europe. The Consortium aims to discover and validate biomarkers that: (1) predict the rate of glycaemic deterioration before and after type 2 diabetes onset; (2) predict the resp

There is concern over the high risk of cardiovascular complications, hypertensive disorders, and other adverse obstetric outcomes among pregnant women with Turner syndrome (TS). A diagnosis of TS is made in some women late in life or not at all. Spontaneous pregnancies are rare in women with TS and are associated with a high rate of complications, especially miscarriage. The use of assisted reprod

This article provides a systematic attempt to analyze the effects of performance appraisals, here conceptualized as tools for executing disciplinary power, and how the agency of employees is shaped. The article demonstrates how agency is enrolled by a broad set of disciplinary technologies aimed at behavior as well as the self, orchestrated in way that effectively short-circuits resistance. Drawin

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into me

During the last decades, there has been concern that the environmental contaminants, such as POPs, may contribute to sex ratio changes in offspring of exposed populations. Accidental exposure to TCDD has been shown to be associated with fewer sons in men who were exposed in adolescence or earlier in life. However, it is not known whether POPs could change the proportion of X- and Y-sperm. A variet

Primary Systemic Vasculitides [PSV: Wegener's granulomatosis (WG), microscopic polyangiitis (MPA), Churg-Strauss syndrome (CSS) and polyarteritis nodosa (PAN)] are rare systemic diseases of unknown etiology; if untreated, they are associated with high morbidity and mortality rates. Changes in the classification and diagnostic improvements during the last decades have increased reported prevalence

Introduction: Moving in very old age is considered to be a major life event and relocation and access to appropriate housing options is a hot topic in the public debate across Europe. For very old people, the decision-making process and aspects influencing relocation is not well studied. Occupational therapy interventions mainly focus on ageing-in-place solutions when aiming for independence and w

Graves' disease (GD) is a complex autoimmune disorder characterized by hyperthyroidism and diffuse goitre. 25-50% of the patients with GD develop eye symptoms, Graves' ophthalmopathy (GO). The overall aim of this thesis was to explore the molecular etiology of GD and GO. By studying gene expression in Studies I, III, and IV, we demonstrated that adipocyte-related immediate early genes (IEGs) incl

We present an implementation of a general weight window generator for global variance reduction in Geant4 based applications. The implementation is flexible and can be easily adjusted to a user-defined model. In this work, the weight-window generator was applied to calculations based on an instrument shielding model of the European Spallation Source, which is currently under construction in Lund,

Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function and insulin secretion. Altered gene expression and epigenetics may contribute to T2D and obesity. However, there is limited information on whether fatty acids alter the genome-wide transcript

Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising