MuscleAtlasExplorer is a freely available web application that allows for the exploration of gene expression data from human skeletal muscle. It draws from an extensive publicly available dataset of 1654 skeletal muscle expression microarray samples. Detailed, manually curated, patient phenotype data, with information such as age, sex, BMI and disease status, are combined with skeletal muscle gene

Nitric oxide (NO) is a gas that serves as a ubiquitous signaling molecule participating in physiological activities of various organ systems. Nitric oxide is produced in the endocrine pancreas and contributes to synthesis and secretion of insulin. The potential role of NO in insulin secretion is disputable – both stimulatory and inhibitory effects have been reported. Available data indicate that e

BACKGROUND: The comparative efficacy and safety of ticagrelor versus clopidogrel in older patients with myocardial infarction (MI) has received limited study. METHODS: We performed an observational analysis of all patients ≥80 years (n=14 005) who were discharged alive with aspirin combined with either clopidogrel (60.2%) or ticagrelor (39.8%) after a MI between 2010 and 2017 registered in the nat

The Common European Framework of Reference has stimulated research on the relation between linguistic competence and communicative competence. Such studies have often used linguistic measures from the Complexity-Accuracy-Fluency (CAF) paradigm to objectively tap into the linguistic competence of language learners; others have used Processability Theory. This study contributes to this research by m

Type 1 diabetes (T1D) and celiac disease (CD) share common genetic loci, mainly within the human leukocyte antigen (HLA) class II complex. Extended genotyping of HLA class II alleles and their potential risk for developing both diseases remains to be studied. The present study compared extended HLA-class II gene polymorphisms in children with T1D, CD, and a subgroup diagnosed with both diseases (T

The 2015 Paris Agreement encourages stakeholders to implement sustainable forest management policies to mitigate anthropogenic emissions of greenhouse gases (GHG). The net effects of forest management on the climate and the environment are, however, still not completely understood, partially as a result of a lack of long-term measurements of GHG fluxes in managed forests. During the period 2010–20The 2015 Paris Agreement encourages stakeholders to implement sustainable forest management policies to mitigate anthropogenic emissions of greenhouse gases (GHG). The net effects of forest management on the climate and the environment are, however, still not completely understood, partially as a result of a lack of long-term measurements of GHG fluxes in managed forests.During the period 2010–2013,

Difficulty in obtaining bone tissue is an obstacle to studying epigenetics to understand gene–environment interactions, and their role in disease pathogenesis. Blood is an obvious alternative and in this proof of principle study, our aim was to systematically investigate whether blood is a viable surrogate for bone. We measured epigenome-wide DNA methylation at 850 K CpG sites in matched trabecula

In this paper two hypotheses concerning the structure of moral systems are suggested, First, that morality should be regarded as a normative standard, originating and moulded in ritual interaction, with the supreme function of maintaining self-consecration of the group. Consequently, the most prominent class of moral norms concerns faithfulness, basically in terms of loyalty to the group, symbolic

The overall aim of this thesis is to examine how walking as a transport mode is constructed in the planning realm, affected by the built environment and perceived by the individual. This aim is related to the following research questions: (1) How are pedestrians and walking understood, constructed and perceived in the planning context? (2) How does individual traits and the built environment affec

This paper analyzes how the influence of firm-level innovation determinants varies over the industry life cycle. Two sets of determinants are distinguished: (1) determinants of a firm's innovation propensity, i.e. the likelihood of being innovative and (2) determinants of its innovation intensity, i.e. innovation sales. By combining the literature emphasizing firms' internal resources (micro-level

This paper draws on two experiences of undertaking comparative research in England,Sweden and Italy, and offers a discussion of the kinds of dilemmas raised in relation tolanguage and meaning surfaced by these. Its primary focus is to examine the reflexiveconstruction of meaning, both in relation generally to the workings of an internationalresearch team and, more specifically, how such constructi

Guided by complexity theory, in this article, we argue that a complex understanding of disaster response management can be achieved by making multiple, transparent and modest interpretations. We suggest an analytical framework in which multiple system interpretations are constructed, all based on explicit analytical choices according to three aspects: (1) system dimension, (2) system scope and (3)

The Church has been a dominant actor in the history of care and social support, but it met several restrictions during the 20th Century. The Church of Sweden now has,since the separation from the state A.D. 2000, the possibility to act as a "welfare entrepreneur". But the willingness to do so seems limited. Even if innovative examples are seen the parishes hesitate for organisational and ideologic

Firm performance in the periphery: on the relation between firm-internal knowledge and local knowledge spillovers. Regional Studies. One of the most established arguments in regional studies is that knowledge dynamics shape thegeography of economic activities and, more specifically, that knowledge-intensive activities benefit from collocation due to knowledge spillovers, local buzz and access to l