We currently are witnessing a serious attrition of physicians specializing in hemophilia treatment in Europe and the United States while most physicians who complete training in hematology-oncology choose oncology practice as their career. Nevertheless, recent therapeutic developments, including advances in prophylaxis and inhibitor management, have renewed the demand for experts in hemophilia and

Background: Studies during the 1990s showed that it was possible to reduce the rate of negative appendectomies by using various diagnostic methods. The present study aims to evaluate the effect on diagnostic accuracy of implementation of repeated clinical examination and blood tests in a small county hospital without possibilities of radiological assistance on a 24-hour basis. Methodology: Prospec

To evaluate the effects of dietary phospholipids on plasma lipoproteins in the postprandial phase six normolipidemic men were fed alternatively a test meal rich in phosphatidylcholine and a control meal low in phosphatidylcholine. Plasma very low-density lipoproteins, low-density lipoproteins, and high-density lipoproteins were isolated at 2, 4 and 6 h after the meals. The changes in lipoprotein c

The bacteria Staphylococcus aureus is part of the normal bacterial flora and produces a repertoire of enterotoxins which can cause food poisoning and toxic shock and might contribute to the pathogenesis of inflammatory diseases. These enterotoxins directly cross-link the T cell receptor with MHC class II, activating large amounts of T cells and are therefore called superantigens. It was recently d

Rupture of atherosclerotic plaques is the major cause of acute coronary events (CEs). Plaque destabilization is the consequence of an imbalance between inflammatory-driven degradation of fibrous tissue and smooth muscle cell-dependent tissue repair. Proinflammatory factors have been documented extensively as biomarkers of cardiovascular risk but factors that contribute to stabilization of atherosc

Atherosclerosis is an immune-mediated inflammatory disease of the arterial wall, with both the innate and adaptive immune systems responding to many endogenous and exogenous antigens. Both proatherogenic as well as atheroprotective roles have been identified for the immune system in atherosclerosis. Hence, it is conceivable that an immunomodulatory strategy via active immunization against many of

The IDEM3 maturity model is a process improvement framework that can be used by an organisation to assess and improve their IT dependability management processes. The framework focuses on the coordination of IT management and safety management within an organisation. In this paper, an evaluation plan for the maturity model is presented to evaluate its applicability, assessment accuracy, and practi