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A recently published genome wide association study identified 29 single nucleotide polymorphisms (SNPs) influencing blood pressure (BP). Case-control studies suggest that a genetic risk score (GRS) based on these 29 SNPs affect the risk of cardiovascular disease (CVD), but its role for CVD at population level is unknown. Here, we prospectively evaluate the impact of this polygenetic BP component o

Context: Immune functions seem to have connections to variations in body fat mass. Studies of knockout mice indicate that endogenous interleukin (IL)-1 can suppress mature-onset obesity. Objective: To systematically investigate our hypotheses that single- nucleotide polymorphisms (SNPs) and/or haplotypes variants in the IL-1 gene system are associated with fat mass. Subjects: The Gothenburg osteop

The present article is part of a larger project investigating the various types of linguistic change that affected and might affect the word class traditionally known under the label of interjection. The results of our research, as outlined here, concern the inter-linguistic mobility of units, i.e., borrowings, which in the source language can be (but not necessarily) interjections, and which are

Genetisk rådgivning (vägledning) etablerades inom svensk sjukvård under 1960- och 1970-talet. Samtidigt stärktes föreställningen om individens självbestämmande i reproduktiva frågor, en uppfattning som hade börjat formuleras redan under 1950-talet. I artikeln diskuteras hur den genetiska rådgivningen som tidigare baserats på empiriska riskberäkningar under 1960- och 1970-talet fick en delvis annan

Background: Periarticular osteopenia is an early sign of incipient joint injury in rheumatoid arthritis (RA), but cannot be accurately quantified using conventional radiography. Digital X-ray radiogrammetry (DXR) is a computerized technique to estimate bone mineral density (BMD) from hand radiographs. The aim of this study was to evaluate whether decrease in BMD of the hands (BMD loss), as determi

Type 1 diabetes is a lifelong, chronic disease, that generally has a sudden onset early in life, which changes the conditions for the affected child and the child’s family. The overall purpose of this thesis was to explore the socioeconomic consequences of childhood onset type 1 diabetes and through this investigate how an early life health shock can affect adult socioeconomic status. The four inc

Some patients with a uni- or bilateral hand- or forearm amputation cannot use a hand prosthesis, although high-tech prostheses have been developed. A hand transplantation, particularly for those with bilateral amputations, may be an alternative solution. In a hand-transplanted patient, grip function, strength, sensibility and subsequent improved quality of life can be restored. Risks related to im

Recent reports suggest that immigrants from Middle Eastern countries are a high-risk group for type 2 diabetes (T2D) compared with Swedes, and that the pathogenesis of T2D may be ethnicity-specific. Deregulation of microRNA (miRNA) expression has been demonstrated to be associated with T2D but ethnic differences in miRNA have not been investigated. The aim of this study was to explore the ethnic s

The aim of this paper is to compare the spatial patterns of innovation and knowledge linkages of a biopharmaceutical and an agro-food biotech cluster. Dissimilarities can be expected based on substantial differences in terms of historical technological regimes and sectoral innovation system dynamics between the agro-food and pharmaceutical industries in general and particularly the distinctive ana

The purpose of the study was to investigate the long-term associations between smoking habits, environmental tobacco smoke exposure (ETS), carotid intima-media thickness (IMT) progression rate, and rate of lumen diameter reduction in the carotid artery during a 16-year follow-up. Another objective was to investigate if an effect of smoking on progression rate could be explained by increased low gr