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AIMS/HYPOTHESIS: The aim of this study was to ascertain whether treatment of GAD65 autoantibody (GADA)-positive diabetic patients with alum-formulated recombinant GAD65 (GAD-alum) is safe and does not compromise beta cell function. METHODS: This Phase 2, placebo-controlled, dose-escalation clinical trial, which was randomized through a central office, was performed in 47 GADA-positive type 2 diabe

High-resolution laser-spectroscopy measurements of hyperfine structure and isotope shifts were performed for the 6snd 1 D 2 sequence of Ba-I in the regionn=12–24. Stepwise laser excitations of a collimated atomic beam were used. A strong influence on the hyperfine structure is observed at the perturbation atn=14, caused by interaction with the 5d7d configuration. Whereas the isotope shift for the

The epidemiological evidence for an obesity-cancer association is solid, whereas the association between obesity-associated lipoprotein levels and cancer is less evident. We investigated circulating levels of Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB), LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) and association to risk of overall cancer and common cancer forms. The Malmö Diet and C

The paper presents a sample design of a multi-storey building with respect to the fire safety. Three design strategies are examined, a standard solution according to the requirements, a fire safety engineering design without a sprinkler system and finally a fire safety engineering design with a sprinkler system. The objective was to demonstrate different design strategies and still comply with the

The pandemic of type 2 diabetes is threatening the entire world population. The number of obese people in the world has quadrupled over the last 30 years. It is clear that the human genome has not undergone such a rapid change, and thus alone does not explain the increased obesity. In fact, the rapidly changing society seems to be on a collision course with the genome. Through gene research we may

ABSTRACT Introduction. Sexual coercion is recognized as a serious societal problem. Correlates and risk factors of sexually abusive behavior in females are not well known. Aim. Etiological theory and empirical study of female perpetrators of sexual coercion are usually based on small or highly selected samples. Specifically, population-based data are needed to elucidate risk/protective factors. Ma

Context: Immune functions seem to have connections to variations in body fat mass. Studies of knockout mice indicate that endogenous interleukin (IL)-1 can suppress mature-onset obesity. Objective: To systematically investigate our hypotheses that single- nucleotide polymorphisms (SNPs) and/or haplotypes variants in the IL-1 gene system are associated with fat mass. Subjects: The Gothenburg osteop

The present article is part of a larger project investigating the various types of linguistic change that affected and might affect the word class traditionally known under the label of interjection. The results of our research, as outlined here, concern the inter-linguistic mobility of units, i.e., borrowings, which in the source language can be (but not necessarily) interjections, and which are

Background: Nephrolithiasis (NL) is known to be associated with gout, although there are few comparative studies on risk and risk factors for NL in gout compared to population cohorts. In this cohort study we investigated: (1) overall incidence of NL in gout (cases) and general population controls; (2) risk and risk factors (common comorbidities and medications) for first-time NL in cases and cont

STUDY QUESTION: Do serum levels of anti-Müllerian hormone (AMH) change in women of reproductive age following dietary and surgery-induced weight loss?SUMMARY ANSWER: AMH levels increased after very low-calorie diet (VLCD) before surgery and decreased at 6 and 12 months after Roux-en-Y gastric bypass (RYGB), beyond expected normal age-related decline.WHAT IS KNOWN ALREADY: Obesity has negative effe

Little is known about the demographic/life-style/physiological determinants explaining the variation of serum perfluoroalkyl acid (PFAA) concentrations in children. We identified significant determinants in children and investigated the influence of low-level PFAA-contaminated drinking water (DW) (<10 ng L-1 of single PFAAs) on serum concentrations. Four perfluorosulfonic acids (PFSAs) and 11 perf

Background: Diet is a determinant of gut microbiota. Both diet and gut microbiota have been linked to metabolic diseases. Objective: We aimed to examine data-driven food patterns in relation to the prevalence of prediabetes and gut microbiota composition and food pattern-associated bacteria in relation to prediabetes. Methods: Food patterns were extracted using principal component analysis in 1726

The aim of the paper is to discuss, with a broadly postcolonial sensibility, the complex role that language has come to play in the contemporary process of globalization. It attempts to show that language, besides being a medium of communication, has come to play a crucial role in companies’ conquest of the global market, on the one hand, and in defending a general idea of an imaginary homogenous