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BACKGROUND: Women with a history of adverse pregnancy outcomes have a higher risk of coronary heart disease. Emerging evidence suggests that women with a history of preeclampsia have a different pattern of overall coronary atherosclerosis and that they at the time of myocardial infarction (MI) more frequently present with ST-segment elevation MI (STEMI) compared to women with no such history.OBJEC

Background:Non-motor symptoms (NMS) reduce quality of life in Parkinson’s disease (PD) patients, who experience three times more NMS than individuals without PD. While there are international and national NMS treatment guidelines, their implication in clinical practice remains unclear.Objective:This study aimed to investigate the adherence to pharmacological NMS treatment guidelines in patients wi

Climate change risk assessment studies focus on identifying and analyzing different risks considering several climate change scenarios and on evaluating the cost-effectiveness of different adaptation measures. However, risk acceptability is often not reflected on in the context of climate change risk studies. Noting that the different climate change scenarios depict drastically contrasting images

Background: Parkinson's disease (PD) is a neurodegenerative disease that leads to progressive disability. Cost studies have mainly explored the early stages of the disease, whereas late-stage patients are underrepresented. Objective: The aim is to evaluate the resource utilization and costs of PD management in people with late-stage disease. Methods: The Care of Late-Stage Parkinsonism (CLaSP) stu

BACKGROUND: The introduction of modern chemotherapy a decade ago has led to increased use of neoadjuvant therapy (NAT) in patients with pancreatic ductal adenocarcinoma (PDAC). A recent North American study demonstrated increased use of NAT and improved operative outcomes in patients with PDAC. The aims of this study were to compare the use of NAT and short-term outcomes in patients with PDAC unde

This study focuses on the purpose of commercial operations as a key factor in the governance of firms. The background is that the extensive discussions about the purpose of the firm, primarily within the economic and legal disciplines, have for a long time been polarized between two positions: shareholder primacy and stakeholder theory. These discussions are carried out in in the context of consid

Reduction of energy use constitutes as an important measure for climate change mitigation. Buildings today account for 40% of the world’s primary energy use and 24% of the greenhouse gas emissions [International Energy Agency (IEA) 2011]0. The concept of passive houses is one of many necessary measures for climate change mitigation. To reach the passive house ambition in cold climates, increased t

Background. Autism spectrum disorder (ASD) is a neurodevelopmental disorder of complex etiology. Although strong evidence supports the causal role of genetic factors, environmental risk factors have also been implicated. This study used a co-twin-control design to investigate low birth weight as a risk factor for ASD. Method. We studied a population-based sample of 3715 same-sex twin pairs partici

Gemcitabine has been the standard chemotherapeutic agent in pancreatic cancer. However, two-thirds of pancreatic tumors display low expression of human equilibrative nucleoside transporter 1 (hENT1), which mediates cellular entry of the drug, and do not respond to gemcitabine therapy. The objective was to determine the costs of gemcitabine overtreatment and the cost-effectiveness of hENT1 testing

Non-compliance with food record submission can induce bias in nutritional epidemiological analysis and make it difficult to draw inference from study findings. We examined the impact of demographic, lifestyle and psychosocial factors on such non-compliance during the first 3 years of participation in a multidisciplinary prospective paediatric study.

The syntax of imperatives makes an interesting test case when investigating word order, verb raising and cliticisation across languages and their acquisition. This paper looks at language differentiation, i.e. language-specific parameter setting, in the imperative constructions of a bilingual child, "Katla", acquiring a verb-raising language, Icelandic, as well as English, not a verb-raising langu

Background: Sodium-glucose co-transporter 2 (SGLT2) inhibitors have been shown to reduce rates of heart failure hospitalisations and cardiovascular death in patients with type 2 diabetes and prior cardiovascular disease. We hypothesised that SGLT2 inhibitors could provide cardiovascular benefits in the post-myocardial infarction setting. We aimed to investigate cardiovascular outcomes of SGLT2 inh

This report presents theories and measurements of the mechanisms af heat transfer in fibrous materials (e.g. insulation of mineral wool type), and measurements of these mechanisms. The present work is part af a larger research program at the Division of Building Technology, Lund Institute of Technology, for investigating the behaviour of fibrous material as thermal insulation. A preliminary versio