Search results

This study investigates patterns of seasonal variation in hours worked by women employed in home-based industrial production in Sweden in the early 20th century. Previous studies often describe workers in this type of production as the most flexible segment of industrial workers, and highly dependent on seasonal fluctuations in supply and demand. However, few have studied this empirically. This st

For many years, a connection between circadian clocks and cancer has been postulated. Here we describe an unexpected function for the circadian repressor CRY2 as a component of an FBXL3-containing E3 ligase that recruits T58-phosphorylated c-MYC for ubiquitylation. c-MYC is a critical regulator of cell proliferation; T58 is central in a phosphodegron long recognized as a hotspot for mutation in ca

In this paper, we investigate the annotation projection of semantic units in a practical setting. Previous approaches have focused on using parallel corpora for semantic transfer. We evaluate an alternative approach using loosely parallel corpora that does not require the corpora to be exact translations of each other. We developed a method that transfers semantic annotations from one language to

Dipeptidyl peptidase 4 (DPP-4) inhibitors are now being clinically utilized as glucose-lowering medications for the treatment of type 2 diabetes. Their widespread use and effective glucose-lowering properties have led to great interest in the mechanism of action of this class of drug. Although it has been well accepted that DPP-4 inhibitors lower glucose in part by increasing postprandial insulin

It is commonly believed that the academic sector does not generate enough value for society. This value is often measured in terms of new firms, patents and products, leading to policy responses which aim to enhance ‘commercialisation’ by academics. However, others maintain that academic research generates benefits in many ways, some of which are difficult to measure, and that policy must look bey

Ecosystem degradation and social sustainability have become important issues in the corporate sphere during the last few decades. However, research discussing corporate social responsibility and related concepts has often focused on larger companies, sometimes neglecting the specifics of small and medium-sized enterprises (SMEs). The main purpose of this study is to examine the relationships betwe

Climate change has become one of the main issues in environmental and sustainability discussions during the last decade. Acting to reduce climate change can be viewed as a prosocial behavior, and previous research has found that personal norms are important in explaining these types of behaviors, together with other attitudinal factors. In this study we use Moral Foundations Theory (MFT) to explor

For business and environmental reasons, increased understanding of green consumer behavior is essential. This paper addresses consumer adoption and non-adoption of a high involvement eco-innovation (the alternative fuel vehicle, AFV). The purpose is to integrate two research streams to explore factors driving and hindering adoption. The factors are rooted in environmental psychology research and t

The catastrophic disruption of the L chondrite parent body in the asteroid belt c. 470 Ma initiated a prolonged meteorite bombardment of Earth that started in the Ordovician and continues today. Abundant L chondrite meteorites in Middle Ordovician strata have been interpreted to be the consequence of the asteroid breakup event. Here we report a zircon U-Pb date of 467.50±0.28 Ma from a distinct be

Stöd till våldsutsatta kvinnor har historiskt sett varit en uppgift för ideellt arbetande kvinnor på kvinnojourer. De senaste två decennierna har kommunernas ansvar för våldsutsatta kvinnor och barn som bevittnat våld förtydligats. Runt om i landet har kommuner gjort satsningar för att höja kompetensen kring våld i nära relationer och för att förbättra samverkan. I vissa fall har personer med ett

The aim of the article is to explore the location and the meaning given to the rainbow flag in places outside the hegemonic centre. Through three case studies in the global North and South, held together by a multi-ethnographic approach, as well as a certain theoretical tension between the rainbow flag as a boundary object and/or a floating signifier, we seek to study where the flag belongs, to wh

Type 1 diabetes is associated with abberations of fat metabolism before and after the clinical onset of disease. It has been hypothesized that the absence of the effect of insulin in the liver contributes to reduced hepatic fat synthesis. We measured hepatic gene expression and serum metabolites before and after the onset of hyperglycemia in a BioBreeding rat model of type 1 diabetes. Functional p

The pathophysiology of diabetes is complex and recent research put focus on the pancreatic islets of Langerhans and the insulin-secreting beta cells as central in the development of the disease. MicroRNAs (miRNAs), the small non-coding RNAs regulating post-transcriptional gene expression, are significant regulators of beta cell function. One of the most abundant miRNAs in the islets is miR-375. Th