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Convincing data demonstrate that screening reduces mortality in colorectal cancer. International organizations and national authorities recommend implementation of colorectal cancer screening programs. There are several different primary methods for screening, including tests of blood in feces, sigmoidoscopy and colonoscopy, all with their inherent advantages and disadvantages. The majority of pro
This article analyses the effect of cultural diversity on employment growth, considering the recent global financial crisis (GFC) as a moderating factor. In doing so, we developed competing hypotheses based on Blau’s theory of heterogeneity versus an alternative perspective which combines the resource-based view (RBV) with social identity theory (SIT). We empirically test such theories using a uni
Failure of the β-cell to secrete enough insulin is a major contributing factor in the pathogenesis of type-2 diabetes (T2D). MicroRNAs provide an extra layer in the regulation of protein expression, and are thus involved in β-cell compensation during development of the disease. In this review, we discuss how microRNAs can regulate their target protein expression and phenotypic output, present the
Though new goals for sustainable cities and transport systems have been developed, decisions and planning at a local level often fail to achieve these ambitions. The purpose of this article is to analyse the factors in local decision-making and planning practice that conduce to urban sprawl and increased car traffic. The article analyses how the conscious application of so-called "day-to-day decis
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highligh
Additive Manufacturing (AM) is a technology that, while removing many of the constraints of traditional manufacturing, imposes some new constraints of its own. Because of this, engineers and designers need to be taught a new set of skills in design for additive manufacturing (DfAM) in order to become competent in designing parts that maximize the benefits offered by AM. Around the world, universit
Significance This project describes the existence of previously unknown non-GPI-anchored CD59 isoforms required for insulin secretion, named CD59-IRIS-1 and CD59-IRIS-2, and finds reduced expression of CD59-IRIS isoforms in human diabetic islets, showing a link between dysregulation of IRIS isoforms and defects in insulin secretion in diabetic patients. These data open a path for future studies in
The embedded verb in North Sámi ECM-constructions can appear in one of three different forms: past participle, progressive and infinitive. The existing descriptions of North Sámi say that the past participle places the embedded event before the higher event, that the progressive (traditionally called aktio essive) expresses temporal coincidence with the higher event, and that the infinitive normal
Nordic welfare states continue to rely on strong central and local governments in the regulation, funding, and implementation of social policies. However, decentralization of particular policy areas (e.g. activation policies) have further increased the significance of the local level in Nordic social policy regulation. However, increasing differences between local entities (e.g. between urban and
System verification and validation are performed to secure that a system fulfils the different quality aspects, such as reliability, functionality, maintainability, performance and user friendliness. Since the verification and validation activities take a large share of the total project budget, efficiency and effectiveness are key issues. In this paper, a method is presented for application of th
