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Fearing mRNA : A Mixed Methods Study of Vaccine Rumours

The first mass-distributed vaccines based on mRNA technology were launched in 2021 to protect against COVID-19, sparking rumours among vaccine critical individuals that these “new” vaccines might be more dangerous to the health than other, “traditional” vaccines. Drawing on rumour theories and social cognitive perspectives, the aim of this chapter is to account for the purpose and the spreading of

Biallelic germline nonsense variant of MLH3 underlies polyposis predisposition

Purpose: Some 10% of familial adenomatous polyposis (FAP) and 80% of attenuated polyposis (AFAP) cases remain molecularly unexplained. We scrutinized such cases by exome-wide and targeted methods to search for novel susceptibility genes. Methods: Exome sequencing was conducted on 40 unexplained (mainly sporadic) cases with FAP or AFAP from Finland. The DNA mismatch repair (MMR) gene MLH3 (MutL Hom

Cell-surface MHC density profiling reveals instability of autoimmunity-associated HLA

Polymorphisms within HLA gene loci are strongly associated with susceptibility to autoimmune disorders; however, it is not clear how genetic variations in these loci confer a disease risk. Here, we devised a cell-surface MHC expression assay to detect allelic differences in the intrinsic stability of HLA-DQ proteins. We found extreme variation in cell-surface MHC density among HLA-DQ alleles, indi