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Background: Long-term frozen storage may alter the results of prostate-specific antigen (PSA) measurements, mainly because of degradation of free PSA (fPSA) in vitro. We compared the effects of long-term storage on fPSA, total PSA (tPSA), and complexed PSA (cPSA) in serum vs EDTA-plasma samples. Methods: We measured fPSA and tPSA concentrations in matched pairs of archival serum and EDTA-plasma sa

Since cancer continues to plague humanity there is large need for development of modalities for both diagnosis and therapy. Most of the currently available methods suffer from serious disadvantages. The treatments, e.g. ionising radiation, chemotherapy, surgery, may themselves induce malignancies or the patient may be physically impaired for a longer period of time. The work presented aims at dev

Alzheimer's disease (AD) is the most prevalent type of dementing disorder. The cortical pathology of AD has been recognized for almost a century. In later years, an associated pathological feature of AD has been identified which affects the white matter. This white matter disease (WMD), defined in the microscope, consists of a subtotal tissue loss of the white matter structural components. WMD is

Environmental education in early childhood has been pointed out as having a great potential to promote pro-environmental behaviour in early years. Among various tools, games and visual items are commonly used for children’s learning and development and therefore, could possibly be used to promote such behaviour among young children. However, their impact on the actual behaviour should be investiga

Background:Non-motor symptoms (NMS) reduce quality of life in Parkinson’s disease (PD) patients, who experience three times more NMS than individuals without PD. While there are international and national NMS treatment guidelines, their implication in clinical practice remains unclear.Objective:This study aimed to investigate the adherence to pharmacological NMS treatment guidelines in patients wi

Background Vitamin D insufficiency (VDI) may be a factor in the development of type 1 diabetes (T1D). The aim of this study is to investigate the presence and persistence of VDI in a large cohort of infants with increased risk of developing T1D, in light of the differences in local supplementation guidelines. Methods In the POInT Study, a multicentre primary prevention study between February 2018

BACKGROUND: The introduction of modern chemotherapy a decade ago has led to increased use of neoadjuvant therapy (NAT) in patients with pancreatic ductal adenocarcinoma (PDAC). A recent North American study demonstrated increased use of NAT and improved operative outcomes in patients with PDAC. The aims of this study were to compare the use of NAT and short-term outcomes in patients with PDAC unde

Background: Parkinson's disease (PD) is a neurodegenerative disease that leads to progressive disability. Cost studies have mainly explored the early stages of the disease, whereas late-stage patients are underrepresented. Objective: The aim is to evaluate the resource utilization and costs of PD management in people with late-stage disease. Methods: The Care of Late-Stage Parkinsonism (CLaSP) stu

Climate change risk assessment studies focus on identifying and analyzing different risks considering several climate change scenarios and on evaluating the cost-effectiveness of different adaptation measures. However, risk acceptability is often not reflected on in the context of climate change risk studies. Noting that the different climate change scenarios depict drastically contrasting images