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Parasites are ubiquitous and can cause significant fitness reductions to their hosts. Therefore, selection for the evolution of host resistance should be strong. However, resistance may be costly and should be traded-off against other fitness related traits. Parasites could therefore have a significant impact on the evolution of fitness related characters of their hosts. It has been suggested that
The introduction suggests a model for defining and categorising different types of graffiti, and the term TTP (Tags/Throw-ups/Pieces) is presented. Chapter I relates the body of research up to the present day and proposes a comprehensive interpretation, based partly on English and German subculture- and socialisation theories. Chapter 2 presents the social background and internal social pattern o
Recent studies suggest that meat intake is associated with diabetes-related phenotypes. However, whether the associations of meat intake and glucose and insulin homeostasis are modified by genes related to glucose and insulin is unknown.
Gut microbiome dysbiosis is associated with numerous diseases, including type 1 diabetes. This pilot study determines how geographical location affects the microbiome of infants at high risk for type 1 diabetes in a population of homogenous HLA class II genotypes.
We studied the incidence of postpartum diabetes after gestational diabetes mellitus and investigated biochemical and clinical predictors of postpartum diabetes. We monitored 174 women with gestational diabetes by performing oral glucose tolerance tests during pregnancy as well as 1, 2 and 5 years postpartum. Women who developed impaired fasting glucose, impaired glucose tolerance or diabetes were
In unsparing efforts to find the hidden primaries, second primary cancers (SPCs) unrelated to cancer of unknown primary (CUP) are found. The detection rates of SPCs after CUP can be considered as measures for the effectiveness of modern diagnostic techniques in finding tumors. We aimed to compare the rates of specific SPCs found after the work-up of CUP and the more sign/symptom-directed diagnosti
The kynurenine pathway metabolite kynurenic acid (KYNA), modulating glutamatergic and cholinergic neurotransmission, is increased in cerebrospinal fluid (CSF) of patients with schizophrenia or bipolar disorder type 1 with psychotic features. KYNA production is critically dependent on kynurenine 3-monooxygenase (KMO). KMO mRNA levels and activity in prefrontal cortex (PFC) are reduced in schizophre
The aim of the study was to assess the ability to recognize ventricular fibrillation (VF) concomitant with pacing artifacts presented either alone or with clinical scenario indicating the cardiac arrest in a patient with implanted pacemaker by members of the medical emergency team.
The purpose of this thesis was to examine the role of growth factors and the urokinase plasminogen activator (uPA) system in human endometrial angiogenesis. Growth factors as well as progesterone increased expression of the main inhibitor of uPA (PAI-1) in primary cultures of endometrial stromal cells. EGF, TGF-beta1 and bFGF increased gene transcription whereas progesterone increased mRNA stabili
The bacterial surface can be thought of as the interface where pathogenic bacteria encounter the human host. Interactions between bacterial surface proteins and human proteins are important determinants of the eventual outcome of infection. A bacterial protein, Protein F1, that binds the human plasma and connective tissue protein fibronectin, was found to reduce the virulence of Streptococcus pyog
