Lyso-PC and macrophage interplay. Scavenging through the fatty side of atherosclerosis
Atherosclerosis is triggered by LDL entrapment in the vessel wall. Oxidation and enzymatic processing of LDL give rise to inflammatory mediators such as lyso-PC. These inflammatory mediators attract monocytes into the vessel wall where they differentiate into macrophages. The macrophages adopt different phenotypes depending on the environment. In vitro, ex vivo, and in vivo studies were combined
