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The polyamines, putrescine, spermidine, and spermine, are essential for all forms of life. The polyamine biosynthetic pathway has been shown to be a potential target for drugs against various trypanosomal parasitic diseases. The two main enzymes in the biosynthesis of polyamines are ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC). ODC catalyzes the first step of pol
In this thesis, in situ doping during growth of III-V semiconductor nanowires, primarily for photovoltaic applications, is investigated. The nanowires were grown by metalorganic vapor phase epitaxy (MOVPE), with gold seed particles. After growth the nanowires were characterized using various techniques, including photoluminescence, transmission electron microscopy and electrical measurements of co
An essential part of the development of new radiopharmaceuticals for use in diagnostic nuclear medicine is the determination of its biokinetic properties. The uptake and turn-over of the radiopharmaceutical in the source organs is of great interest since this could determine whether the radiopharmaceutical would be suitable for clinical use or not. It is also important that the biokinetics and dos
Higher education (HE) is and has been a growing concern for various stakeholders for a considerable time. Sometimes contradictory attempts to reform HE have increased the pressure on academic teachers and contributed to an experience of demand overload. This research conceptualises HE organisations so that dynamics related to change and stability become understandable. A socio-cultural perspective
Sepsis and subsequent multiple organ failure remain the major cause of mortality in intensive care units. Leukocyte-mediated tissue damage is a key feature in septic lung injury. Accumulating data suggest that platelets play a role in inflammation and tissue injury. However, the role of platelets in sepsis-induced leukocyte recruitment and lung edema formation in abdominal sepsis is not demonstrat
The problem which the present study discusses is modernity. The study interprets modernity’s cultural and anthropological dispositions as historical appearances. Consequently, it is situated at the intersection of cultural sociology and historical anthropology. The aim is to generate insight and understanding rather than a coherent theory. The key element consists of combination and variation of c
This thesis deals with the problem of interpreting test scores. The intention has been to explore and elucidate the effects of trait anxiety on test scores that have been obtained in applied research settings. Paper I showed that different relationships between personality traits and cognitive functioning emerged in a group of men with solvent induced chronic toxic encephalopathy (TE; N=57) compa
Parkinson's disease (PD) is a neurodegenerative disorder where the midbrain dopaminergic neurons are lost. Presently there is no cure for PD, and the most common treatment is to replace the lost dopamine pharmacologically by administration of the dopamine precursor L-DOPA. This works very well during the initial treatment period, but unfortunately a majority of the patients develop abnormal involu
Hindered diffusion occurs in the most different processes, as has been described in this thesis. It is very important to have an understanding of the influence of hindered diffusion on the mass transfer rate, especially when competing rate processes are acting simultaneously. Using mathematical modeling and simulation makes it possible to predict the effects of hindered diffusion. The systems that
Glioblastoma multiforme (GBM) is the most malignant and also the most common form of brain tumour in humans. The overall aim of this thesis was to investigate morphological and diagnostics features in human GBM that may be of importance for prognosis and treatment. Immunohistochemically stained tissue sections have been microscopically analysed regarding immuno-reactive cells, cell proliferation,
Dizziness is a common reason for visits to primary health care, especially among elderly patients. From a physiotherapeutic perspective, this thesis aims to study the assessment and treatment of dizzy patients in primary health care. Interventions in papers I, III and IV comprised a vestibular rehabilitation programme. In paper I, patients with multisensory dizziness were randomized to interventi
Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and are ultimately responsible for the continuous production of blood cells throughout life. The regulation of HSCs in vivo is tightly regulated by both intrinsic and extrinsic factors. The Smad-signaling pathway is an evolutionary conserved signaling circuitry with critical functions during embryogenesis and throu
There are two major types of diabetes mellitus, Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D), however a number of subtypes have been defined and classified. Maternally Inherited Diabetes and Deafness (MIDD) and Maturity Onset Diabetes of the Young (MODY) are monogenic forms, whereas Latent Autoimmune Diabetes in Adults (LADA) is thought to be a polygenic subtype similar to T1D. Mutations in the
This work concerns techniques for improvement of the coherence properties of diode lasers so that they may be used in two specific medical applications: (Interstitial) photodynamic therapy (PDT) and laser-induced fluorescence diagnostics. In the first application, spatial coherence is crucial, since the treatment light should be delivered through relatively thin optical fibers to optimize treatmen
The research presented in this thesis investigates sea and aviation transport safety culture, with a focus on perceptions and attitudes. A safety culture reflects the attitudes, beliefs, perceptions, and values that individuals share in relation to safety. Safety culture is often identified as being essential to an organization's ability to manage safety-related aspects of its operations. The aims
Macrophages play an essential role in the defense against infection by phagocytosis and by production of inflammatory mediators. Such mediators are TNF? and eicosanoids. Many microbial agents elicit arachidonate release in macrophages that lead to the formation of eicosanoids. This thesis is based on studies performed with the use of microbial constituents which induce arachidonate release or/and
The treatment of flow in the area of traffic safety has a long tradition. The influence flow has on the number of accidents is, however, often considered so obvious that it tends to be trivial. In this thesis I can show that the relation between flow and accidents holds interesting information. In order to compare countermeasures, or conduct other types of traffic safety comparisons where the flo
The aim of this thesis was to investigate the effects of cortical reorganisational changes following experimental deafferentation and peripheral nerve injury and apply the concept of brain plasticity to enhance sensory re-education following peripheral nerve injury and repair in the hand. In the first two papers the effects on hand function of contralateral deafferentation was investigated. Tourn
In this M.Sc. Thesis of a comparison for sewerage system of the three main municipalities of Turkish Republic of Northern Cyprus (T R N C) has been studied and discussed. The study covers the future population calculations for three municipalities, Nicosia, Famagusta and Kyrenia, by means of Turkish and European standards. The comparisons for sewerage system of the three municipalities are compare
An important indicator of the metabolic capacity of humans is the ability to regulate plasma triacylglycerol levels and to clear triacylglycerol-rich lipoproteins (TRLs) from the circulation after a meal. This is crucial since most of the day is spent in the postprandial state. High concentrations and long circulation times of TRL remnants may be detrimental since these are considered to be highly
