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Radionuclide therapy (RNT) is a generic term for treatment modalities that use a radionuclide labeled to a target-specific molecule. This so-called radiopharmaceutical accumulates in the target, where the ionizing radiation damages the cells. At sufficient levels of radiation, the cells cannot repair themselves. The quantity of the energy deposited in a target region is referred to as the absorbed

In sociology shock is often seen as emblematic of modernity. However, while Benjamin and Simmel famously portray the big city crowd - and by extension modernity itself - as an arena of shock, shock sensations are notable for their absence in depictions of the crowd as well as of modernity as a whole in much contemporary literature. This is evident in depictions involving streets, trains, technolog

The presence of genes in food, encoding some virulence factors, was studied by PCR, and species of Enterobacteriaceae, associated with food, were studied by the DNA-based methods of TTGE, ribotyping and sequencing. The flora of fresh and chill-stored pork were analysed by a culture-independent approach, using specific amplification of 16S rRNA genes followed by cloning and sequencing. No evidence

Intestinal ischemia and reperfusion (I/R) is not infrequent in the clinical situation and the intestinal barrier plays an important role in gut barrier function, preventing not at least septic complications and potentially the development of the multiple organ dysfunction syndrome. Mechanisms of intestinal I/R induced gut epithelial and endothelial barrier dysfunction and remote organ dysfunction

Psychological processes involved in moral cognition were examined in three studies, taking as their starting point the assumption that the cognitive-developmental perspective commonly taken is too narrow and that individual differences and implicit processes need to be taken into consideration. Study I focused on the role of defense mechanisms in moral thinking. A self-report questionnaire was co

Kliniska och experimentella studier av nickelallergi Nickelallergi är vanligt, särskilt hos kvinnor. Nickelallergi leder ofta till periodiskt eller kroniskt eksem, främst på händerna. Dessa eksem kan vara svårläkta och leda till långa sjukskrivningsperioder. Nickel finns överallt i omgivningen och det går inte att helt undvika exposition för denna metall. Clinical and experimental studies in nic

Most cells are crowded with solutes, enzymes, nucleic acids, structural proteins and membranes. Crowding promotes macromolecular interactions and determines major properties of the cellular environment such as viscosity, diffusion and inhomogeneity. Macromolecular interactions that involve enzymes can affect the kinetic and regulatory properties of these, hence the interactions are part of the met

The aim of this investigation has been to study mechanisms by which glucocorticoids inhibit inflammatory processes in vitro. Type IV cytosolic 85 kDa phospholipase A2 (cPLA2) is an important modulator of inflammatory responses that is present in macrophages as well as in other cell types. In macrophages, the synthetic glucocorticoid dexamethasone (dex) was found to reduce the expression of cPLA2 a

Recent research has shown that when decision makers in retrospect are asked to reproduce attractiveness evaluations (of aspects) of important characteristics (attributes) of a chosen and a non-chosen choice alternative, they exaggerate the attractiveness difference between the alternatives. This post-decision attractiveness differentiation (consolidation) works in favor of the chosen alternative.

Internal dosimetry deals with the assessment of absorbed dose for radionuclides distributed inside the body. The absorbed dose is in its turn used for correlation with the biological effect caused by the irradiation. In radioimmunotherapy is however the correlation not easily found and factors influencing this are evaluated and discussed in this work. The internal dosimetry could be subdivided int

For young persons with disabilities it is important to be as everyone else and not deviating from the normative in an unwanted way. Assistive devices are products that persons with disabilities can use to get accessibility to our society. Such products enable the person to participate in activities he or she wishes to take part in. However assistive devices are also a sign for disability, indicati

Acute otitis media (AOM) is a common complication after episodes of respiratory tract infections in childhood. Some children have recurrent episodes and they are often called otitis-prone. These children are prone not only to middle-ear diseases but also to other infectious diseases. The aims of the present study of otitis-prone children and controls were to describe the overall illness and need f

Plasma and urine concentrations of endogenous proteins are frequently used in the diagnosis of kidney diseases and in studies of glomerular filter function. The main issues addressed in these studies were: storage of urine samples for subsequent protein analysis, use of protein concentrations in urine and in plasma in health and as markers of glomerular diseases, and the application of renal plasm

Traditionally the predominant generation has been large synchronous generators providing the system inertia. Nowadays when wind power and other non-synchronously connected units displaces this synchronous generation, the system inertia is reduced. Hence higher rate of change of frequency and larger frequency deviations are expected. This thesis deals with the impact on rate of change of frequency

Since the metal oxide catalysts used in many chemical processes show very high selectivity for the products aimed at, both today and in the future, they play a key role in the environmentally and economically sustainable production of chemical intermediates. Two processes of this sort have been studied in the thesis: the ammoxidation of propane and propene over a Mo-V-Nb-Te-oxide catalyst and the

Accurate calculation of energies for protein reactions is a hard problem. There are many reasons for wanting to calculate these energies, e.g. ligand design and the study of enzyme reactions. There are two major problem involved in these kinds of calculations. First, the large number of local minima in proteins introduces uncertainties when studying single structures. Second, the size of proteins

Under aerobic conditions, most yeasts such as Kluyveromyces lactis, prefer the respiratory pathway and some, such as Saccharomyces cerevisiae prefer less energy efficient fermentative pathway for their energy metabolism. These two metabolic strategies are also known as Crabtree negative and Crabtree positive respectively, and the evolution of the latter has lately been explained by the “make-accum

Aquaporins, or Major Intrinsic Proteins (MIPs), are integral proteins that facilitate transport of water and other small neutral solutes across biological membranes. They belong to a well conserved and ancient family of proteins, present in all organisms ranging from bacteria to plants and humans. The aquaporin family in plants is large, indicating complex and regulated water transport within the

This thesis concerns the interplay between the lipid phase behaviour, domain formation and the permeability of bilayer membranes. An essential part of this work has been the understanding of the phase transitions and equilibrium properties of lipid bilayers. In this approach experimental results of lipid phase behaviour have been correlated to theoretical descriptions of the systems. An isothermal

This work is not so much about religion as about individual religiosity. It is primarily about people practicing Zen, less about Zen Buddhism as a systematic ideology or philosophy. I set out from the start to try to explore the wide gap between theory and practice in Zen. The more abstract doctrines and idealized norms have had a tendency to dominate works on Zen, confessional as well as scholast